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Jan 14, 2020Open    AccessArticle

Phenocopies: Mimics of Inborn Errors of Immunity

Cesar Daniel Alonso-Bello, Sara Elva Espinosa-Padilla, Mariano Daniel Temix-Delfin, Fernando Lozano-Patino, Victoria Isabel Castaneda-Avila, Maria Eugenia Vargas-Camano, María Isabel Castrejón-Vázquez
A phenocopy is defined as a clinical non-inherited phenotype in an indi-vidual, with environmental induction, which is identical to the genetically determined phenotype of another. Until February 2017, the IUIS (Interna-tional Union of Immunological Societies) reported in its classification 354 innate immunity errors and a final group (classification table IX) with con-ditions that are not part of the innate alterations and are ca
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May 20, 2019Open    AccessArticle

Approach to Primary Immunodeficiencies for the Non-Immunologist Physicians

García-López Carlos Alberto, Alcázar-Casarín Emmanuel, Ynga-Durand Mario Alberto, Alonso-Bello César Daniel, Lozano-Patino Fernando, Vargas-Camano María Eugenia, Espinosa-Padilla Sara Elva, González-Serrano Maria Edith, Castrejón-Vázquez María Isabel
Introduction: Primary immunodeficiencies are a spectrum of diseases that encompasses alteration of the innate and adaptive immune response. Isolated lymphocytopenia may be a manifestation of primary immunodeficiency, which is rarely considered as a diagnostic option by non-immunological physicians. Objectives: To conduct a brief review of the primary immunodeficiencies that are most frequently associated with lymphocytopenia in or
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Aug 15, 2017Open    AccessArticle

Vitamin D Deficiency Is Correlated with Severity of Allergic Rhinitis

Melati Sudiro, Bony Wiem Lestari, Teti Madiadipoera, Budi Setiabudiawan, Thaufiq Siddiq Boesoirie
Background: Vitamin D deficiency has been targeted as a cause of the increased incidence of allergic rhinitis. Many factors, including sun exposure, influence vitamin D levels. Indonesia is a country with abundant sunshine exposure throughout the year; therefore, Indonesian residents are not expected to have inadequate vitamin D levels. Objective: This study aimed to investigate whether vitamin D deficiency
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Jun 09, 2017Open    AccessArticle

Severe Allergic Reaction to Oral Artesunate-Amodiaquine Combination Treatment for Malaria: Case Report in the Democratic Republic of Congo

Edouard Kawawa Swana, Christian Katshiza, Oscar Numbi Luboya, Michael J. Bangs
Background: In 2012-2013, a pilot study on implementation of community-based case malaria management by trained community health workers was implemented in southern Katanga Province in the Democratic Republic of Congo (DRC). We report one case of severe adverse reaction that was linked to artesunate-amodiaquine (ASAQ). Case summary: An apparent healthy, 15-year-old Congolese female with a positive rapid diagnostic test for
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Mar 28, 2017Open    AccessArticle

Oral Provocation Test in Non-Steroidal Anti-Inflammatory Drug Hypersensitive Patients Referred to Singapore General Hospital

Chaw Su Naing, Yong Yeow Chong
Introduction: Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed classes of drugs and are easily accessible as over-the-counter anti-inflammatory drugs in Singapore. NSAIDs hypersensitivity is the second most common referral to allergy clinic in a tertiary referral centre. Methods: Referred patients with history of NSAID intolerance were underwent open challenge with 1) putative NSAID to confirm the diagnosis
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