miRNAs regulate a variety of target proteins and signaling pathways associated with epilepsy. We conducted a cross-sectional study of publications associated with microRNA in epilepsy in the past 10 years using bibliometric methods. Our results showed that the number of publications elevated gradually, peaking in 2020. Countries/institutions collaboration network showed that extensive international cooperation between countries existed and China published the most of papers in this field. USA, Ireland, and other Western countries are also active in this field. Moreover, we identify the most influential authors and publications. Last, Keyword co-occurrence network indicated miR-146a, miR-155 and miR-132 were hotspots and the most studied microRNAs, miR-146a, miR-155 and miR-132 may be potential targets and more mechanisms associated with microRNA in epilepsy will be found.
Cite this paper
Wang, S. and Jiang, G. (2022). Trends and Hotspots of microRNAs in Epilepsy: A 10-Year Cross-Sectional Study. Open Access Library Journal, 9, e8650. doi: http://dx.doi.org/10.4236/oalib.1108650.
Ngugi, A.K., Bottomley, C., Kleinschmidt, I., Sander, J.W. and Newton, C.R. (2010) Estimation of the Burden of Active and Life-Time Epilepsy: A Meta-Analytic Approach. Epilepsia, 51, 883-890. https://doi.org/10.1111/j.1528-1167.2009.02481.x
Albanese, M., Chen, Y.A., Hüls, C., Gärtner, K., Tagawa, T., Mejias-Perez, E., et al. (2021) MicroRNAs Are Minor Constituents of Extracellular Vesicles That Are Rarely Delivered to Target Cells. PLoS Genetics, 17, e1009951.
https://doi.org/10.1371/journal.pgen.1009951
Bej, S. and Basak, J. (2014) MicroRNAs: The Potential Biomarkers in Plant Stress Response. American Journal of Plant Sciences, 5, 748-759.
https://doi.org/10.4236/ajps.2014.55089
Hu, K., Xie, Y.Y., Zhang, C., Ouyang, D.S., Long, H.Y., Sun, D.N., et al. (2012) MicroRNA Expression Profile of the Hippocampus in a Rat Model of Temporal Lobe Epilepsy and miR-34a-Targeted Neuroprotection against Hippocampal Neurone Cell Apoptosis Post-Status Epilepticus. BMC Neuroscience, 13, Article No. 115.
https://doi.org/10.1186/1471-2202-13-115
Xiao, Y., Wu, H., Wang, G. and Mei, H. (2021) Mapping the Worldwide Trends on Energy Poverty Research: A Bibliometric Analysis (1999-2019). International Journal of Environmental Research and Public Health, 18, 1764.
https://doi.org/10.3390/ijerph18041764
Zhou, X. and Zhang, D. (2021) Multimorbidity in the Elderly: A Systematic Bibliometric Analysis of Research Output. International Journal of Environmental Research and Public Health, 19, 353. https://doi.org/10.3390/ijerph19010353
Aronica, E., Fluiter, K., Iyer, A., Zurolo, E., Vreijling, J., van Vliet, E.A., et al. (2010) Expression Pattern of miR-146a, an Inflammation-Associated microRNA, in Experimental and Human Temporal Lobe Epilepsy. European Journal of Neuroscience, 31, 1100-1107. https://doi.org/10.1111/j.1460-9568.2010.07122.x
Omran, A., Peng, J., Zhang, C.L., Xiang, Q.L., Xue, J.F., Gan, N., et al. (2012) Interleukin-1 beta and microRNA-146a in an Immature Rat Model and Children with Mesial Temporal Lobe Epilepsy. Epilepsia, 53, 1215-1224.
https://doi.org/10.1111/j.1528-1167.2012.03540.x
Roncon, P., Soukupova, M., Binaschi, A., Falcicchia, C., Zucchini, S., Ferracin, M., et al. (2015) MicroRNA Profiles in Hippocampal Granule Cells and Plasma of Rats with Pilocarpine-Induced Epilepsy—Comparison with Human Epileptic Samples. Scientific Reports, 5, Article No. 15. https://doi.org/10.1038/srep14143
Cui, L.L., Tao, H., Wang, Y., Liu, Z., Xu, Z.E., Zhou, H.H., et al. (2015) A Functional Polymorphism of the microRNA-146a Gene Is Associated with Susceptibility to Drug-Resistant Epilepsy and Seizures Frequency. Seizure-European Journal of Epilepsy, 27, 60-65. https://doi.org/10.1016/j.seizure.2015.02.032
An, N., Zhao, W., Liu, Y.C., Yang, X.F. and Chen, P. (2016) Elevated Serum miR-106b and miR-146a in Patients with Focal and Generalized Epilepsy. Epilepsy Research, 127, 311-316. https://doi.org/10.1016/j.eplepsyres.2016.09.019
Li, Y., Wang, J.Q., Jiang, C.M., Zheng, G., Lu, X.P. and Guo, H. (2016) Association of the Genetic Polymorphisms in Pre-microRNAs with Risk of Childhood Epilepsy in a Chinese Population. Seizure-European Journal of Epilepsy, 40, 21-26.
https://doi.org/10.1016/j.seizure.2016.04.011
Kong, H.M., Yin, F., He, F., Omran, A., Li, L.H., Wu, T.H., et al. (2015) The Effect of miR-132, miR-146a, and miR-155 on MRP8/TLR4-Induced Astrocyte-Related Inflammation. Journal of Molecular Neuroscience, 57, 28-37.
https://doi.org/10.1007/s12031-015-0574-x
He, F., Liu, B., Meng, Q., Sun, Y., Wang, W.W. and Wang, C. (2016) Modulation of miR-146a/Complement Factor H-Mediated Inflammatory Responses in a Rat Model of Temporal Lobe Epilepsy. Bioscience Reports, 36, 12.
https://doi.org/10.1042/BSR20160290
Zhang, H.L., Lin, Y.H., Qu, Y. and Chen, Q. (2018) The Effect of miR-146a Gene Silencing on Drug-Resistance and Expression of Protein of P-gp and MRP1 in Epilepsy. European Review for Medical and Pharmacological Sciences, 22, 2372-2379.
Ashhab, M.U., Omran, A., Kong, H., Gan, N., He, F., Peng, J., et al. (2013) Expressions of Tumor Necrosis Factor Alpha and microRNA-155 in Immature Rat Model of Status Epilepticus and Children with Mesial Temporal Lobe Epilepsy. Journal of Molecular Neuroscience, 51, 950-958. https://doi.org/10.1007/s12031-013-0013-9
Tili, E., Michaille, J.J., Cimino, A., Costinean, S., Dumitru, C.D., Adair, B., et al. (2007) Modulation of miR-155 and miR-125b Levels Following Lipopolysaccharide/TNF-Alpha Stimulation and Their Possible Roles in Regulating the Response to Endotoxin Shock. Journal of Immunology (Baltimore, Md: 1950), 179, 5082-5089.
https://doi.org/10.4049/jimmunol.179.8.5082
Ceppi, M., Pereira, P.M., Dunand-Sauthier, I., Barras, E., Reith, W., Santos, M.A., et al. (2009) MicroRNA-155 Modulates the Interleukin-1 Signaling Pathway in Activated Human Monocyte-Derived Dendritic Cells. Proceedings of the National Academy of Sciences of the United States of America, 106, 2735-2740.
https://doi.org/10.1073/pnas.0811073106
Li, T.R., Jia, Y.J., Wang, Q., Shao, X.Q., Zhang, P. and Lv, R.J. (2018) Correlation between Tumor Necrosis Factor Alpha mRNA and microRNA-155 Expression in Rat Models and Patients with Temporal Lobe Epilepsy. Brain Research, 1700, 56-65.
https://doi.org/10.1016/j.brainres.2018.07.013
Huang, L.G., Zou, J. and Lu, Q.C. (2018) Silencing rno-miR-155-5p in Rat Temporal Lobe Epilepsy Model Reduces Pathophysiological Features and Cell Apoptosis by Activating Sestrin-3. Brain Research, 1689, 109-122.
https://doi.org/10.1016/j.brainres.2017.11.019
Duan, W., Chen, Y. and Wang, X.R. (2018) MicroRNA-155 Contributes to the Occurrence of Epilepsy through the PI3K/Akt/mTOR Signaling Pathway. International Journal of Molecular Medicine, 42, 1577-1584.
https://doi.org/10.3892/ijmm.2018.3711
Vezzani, A., Maroso, M., Balosso, S., Sanchez, M.A. and Bartfai, T. (2011) IL-1 Receptor/Toll-Like Receptor Signaling in Infection, Inflammation, Stress and Neurodegeneration Couples Hyperexcitability and Seizures. Brain, Behavior, and Immunity, 25, 1281-1289. https://doi.org/10.1016/j.bbi.2011.03.018
Zhang, Z.J., Wang, Z.Z., Zhang, B. and Liu, Y. (2018) Downregulation of microRNA-155 by Preoperative Administration of Valproic Acid Prevents Postoperative Seizures by Upregulating SCN1A. Molecular Medicine Reports, 17, 1375-1381.
https://doi.org/10.3892/mmr.2017.8004
Qian, Y., Song, J., Ouyang, Y., Han, Q., Chen, W., Zhao, X., et al. (2017) Advances in Roles of miR-132 in the Nervous System. Frontiers in Pharmacology, 8, Article No. 770. https://doi.org/10.3389/fphar.2017.00770
Peng, J., Omran, A., Ashhab, M.U., Kong, H., Gan, N., He, F., et al. (2013) Expression Patterns of miR-124, miR-134, miR-132, and miR-21 in an Immature Rat Model and Children with Mesial Temporal Lobe Epilepsy. Journal of Molecular Neuroscience: MN, 50, 291-297. https://doi.org/10.1007/s12031-013-9953-3
Xia, L., Li, D.J., Lin, C.W., Ou, S.C., Li, X.R. and Pan, S.Q. (2017) Comparative Study of Joint Bioinformatics Analysis of Underlying Potential of “neurimmiR”, miR-212-3P/miR-132-3P, Being Involved in Epilepsy and Its Emerging Role in Human Cancer. Oncotarget, 8, 40668-40682.
https://doi.org/10.18632/oncotarget.16541
