A new dolabrane dinorditerpene, tagalsine X(1), was isolated from the
leaves of Ceriops tagal, along with
five known analogues (2-6). Their structures were established on the basis of
spectroscopic data or comparison with the literatural data. Their cytotoxic
activities against four human carcinoma cell lines (CNE-2, HCT-116, HepG2and A549)
were also evaluated, which displayed that only compound 2 had significant
cytotoxicity against those cell lines with IC50 values of 13.57, 42.32, 11.21
and 15.23 μM, respectively.
Cite this paper
Wu, X. , Liao, H. , Lu, H. and Zhang, C. (2016). A New Dolabrane Dinorditerpene from Ceriops tagal. Open Access Library Journal, 3, e2957. doi: http://dx.doi.org/10.4236/oalib.1102957.
Wang, H., Li, M.Y. and Wu, J. (2012) Chemical Constituents and Some Biological
Activities of Plants from the Genus Ceriops. Chemistry & Biodiversity, 9, 1-11. http://dx.doi.org/10.1002/cbdv.201000299
Du, S.S., Wang, C.F., Li, J., Zhang, H.M., Liu,
Q.Z., Liu, Z.L. and Deng, Z.W. (2011) Antifeedant Diterpenoids against Tribolium castaneum from
the Stems and Twigs of Ceriops tagal (Rhizophoraceae). Molecules, 16, 6060-6067. http://dx.doi.org/10.3390/molecules16076060
Wu, X., Liao, H.B.,
Zhu, X.H., Lu, H.Y., Zeng, X.B., Cui, L., Lv, X.H., Li, Y.Q. and Zhang, C.H.
(2016) Two New Dammarane Triterpenes
from the Leaves of Ceriops tagal. Records of Natural Products,
10, 628-632.
Hu, W.M., Li, M.Y., Li, J., Xiao, Q., Feng, G. and Wu, J. (2010) Dolabranes from the Chinese Mangrove, Ceriops tagal. Journal of Natural Products, 73,
1701-1705.
http://dx.doi.org/10.1021/np100484w
Yang, Y., Zhang, Y.,
Liu, D., Li-Weber, M., Shao, B. and Lin, W. (2015) Dolabrane-Type Diterpenes from
the Mangrove Plant Ceriops tagal with Antitumor Activities. Fitoterapia, 103, 277-282. http://dx.doi.org/10.1016/j.fitote.2015.04.016