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Hypergammaglobulinemic purpura of waldenstorm associated with sjogren’s syndrome in a young female responding to rituximab treatment  [PDF]
Neeraj Jain, Lalit Duggal
Case Reports in Clinical Medicine (CRCM) , 2013, DOI: 10.4236/crcm.2013.22034
Abstract:

Hypergammaglobulinemic Purpura of Waldenstorm is one of the uncommon conditions with purpura and is often associated with collagen vascular disease. It is difficult to treat and sometimes needs anti CD 20 molecules for resistant cases.

Persistent Xerophthalmia in a Patient with Rheumatological Disease and Priiviary Sjogren’s Syndrome: Case Report from Northern Brazil  [PDF]
Camile Smith de Oliveira Brito, Horlando Junior Santos Lages Alcantara, Joao de Joao Oliveira Leitao Limeira, Julie Souza da Silvat, Sebastiao Barreto Falcao Neto, Joao Vlctor Oliveira de Melot, Youssef Sabba Tayah, David Tayah, Milton Ruiz Alves
Open Journal of Ophthalmology (OJOph) , 2023, DOI: 10.4236/ojoph.2023.132024
Abstract: This case study aims to contribute to the literature in order to highlight the importance of this collaboration between medical specialties. A female patient R.N.N. F, age 66, from the city of Manaus, with a previous diagnosis of Sjogren’s syndrome in regular follow-up by the Rheumatology team at the Araujo Lima outpatient clinic and referred to the Ophthalmology sector for complementary evaluation related to visual discomfort. The fundoscopy performed in the patient was within normal limits, but the symptoms experienced by her proved to be an important clinical finding, which has ratified the need for regular and multidisciplinary follow-up. This report unequivocally demonstrates that even in the face of tests considered within the expected limits for a given population, the clinical presentation can be specific and particular for each analyzed individual. Early screening exams should contemplate the patient in a holistic and individualized way whenever possible.
SJOGREN-LARSSON SYNDROME
FAWAD MUZAFFAR
The Professional Medical Journal , 2006,
Abstract: We present a case report of two brothers suffering from Sjogren-Larsson syndrome, who were bornto consanguineous parents. Sjogren-Larsson syndrome is one of the congenital icthyoses with an autosomal recessiveinheritance . It is characterized by the combination of 1 congenital ichthyosis with spastic diplegia, moderate mentalretardation and retinopathy.2,3,16. Defects in essential fatty acid metabolism have been attributed to as the cause4,8,13,15.
Inductores de lágrimas: andrógenos y gammaglobulinas humanas
Santos Lagresa,María Nila; Martínez Suárez,Nereyda; Vilches Lescaille,Deysi; Santos Lagresa,Caridad Marisela;
Revista Cubana de Oftalmolog？-a , 2000,
Abstract: therapeutical responses are compared in patients diagnosed of sj？gren syndrome, presenting with keratoconjunctivitis sicca resistant to traditional treatments of artificial tears, lenses and others in two groups of patients (18 and 32 cases) treated with human gammaglobulin: intacglobin (100 mg/body weight every 15 days in a intercapsular subcutaneos way for 3 months), and depot androgens (100 mg every 15 days in an intramuscular way for three months). level of igg, iga, igm, and ige immunoglobulins, count of blood cells-rheumatoid factor, c-reactive protein, and microbiological study. both treatments show an significant statistically improve p < 0,001 in results obtained in shirmer i test, and in negative corneal injuries, assessed using slit lamp after fluorescein staining. we propose advantageous use of gammaglobulins because of contraindications on utilization of androgens.
Salivary gland scintigraphy in sj gren syndrome
Betancourt-Pi？eres Aiken Felipe,Milanés-Pérez Rosa Isabel,Bonnet-Palencia Igor Iván,Padilla-Tovar Lacides
Revista Ciencias Biomédicas , 2011,
Abstract: Sj gren syndrome is a systemic autoimmune disease that mainly affects exocrineglands, such as the salivary and lacrimal glands, causing a decline in their secretions.This disease is also known as Sicca Syndrome. It is reported a clinical case of a womanwho fulfill all diagnostic criteria of European-American Consensus of Sjogren Syndrome2002.RESUMEN:El Síndrome de Sj gren es una enfermedad sistémica autoinmune que afectaprincipalmente las glándulas exocrinas del organismo, como las salivales y las lacrimalesprovocando una disminución de sus secreciones, por lo que también se denominasíndrome seco. Se presenta caso clínico de una paciente de sexo femenino la cualcumple todos los criterios clasificatorios del Consenso Europeo Americano 2002 para elSíndrome de Sjogren.
NEW KNOWLEDGE ABOUT THE SJOGREN SYNDROME
Sonja Zivkovic,Gordana Zlatanovi？,Gordana Stankovic-Babic,Predrag Jovanovic
Acta Medica Medianae , 2001,
Abstract: The Sjogren syndrome is a clinic-pathological unit characterized by dry eyes(keratoconjunctivitis sicca) and dry mouth (xerostomia). It can be solitary or acomplication of other auto-immune disease. A complex clinic symptomatology, anincreasing frequency of the Sjogren syndrome, a still difficult timely detection, somenew knowledge about the pathogenic mechanisms as well as a new approach to itstreatment - these are all the reasons for the histologic and histochemical examination of the operation material of the salivary gland primarily from the standpoint of ahistologic detection of the immunological markers. The operation material fixationwas done in formalin, while the laboratory treatment of the tissue in the autotechnicon.The laboratory sections were dyed with classical and histochemicalpainting methods. In all the patients the dominant were tumefactions in the parotidgland region, with less prominent kerastomy, while the eye changes were slight. Inthe histologic way the periacinous and the periduct lymphoplasmocyte infiltrationwas found as well as hyperplasia of the lymph follicles joined with hyperplasia oftheir germination centers. The setting-up of the diagnosis not earlier then at thesalivary gland's operation material points to a very complex clinic symptomatologyas well as to insufficient experience of the physicians due to formerly very rare whiletoday all the more frequent Sjogren syndrome.
Analysis of 31 Cases of Female Sjogren’s Syndrome Patients with Changes in Muscle Mass  [PDF]
Yubao Zhang, Meng Wang
Open Access Library Journal (OALib Journal) , 2020, DOI: 10.4236/oalib.1106872
Abstract: Objective: To observe and analyze the changes in muscle mass in patients with Sjogren’s syndrome and sarcopenia. Methods: From October 2016 to December 2018, the muscle mass of 31 female patients with Sjogren’s syndrome who underwent DXA testing in Linyi City People’s Hospital was tested, and the changes in muscle mass of patients with Sjogren’s syndrome were investigated. Results: The incidence of decreased skeletal muscle mass in patients with Sjogren’s syndrome was lower. The upper and lower limbs of patients with decreased skeletal muscle mass were significantly lower than those with normal skeletal muscle mass (P < 0.01). Conclusion: Patients with Sjogren’s syndrome will be accompanied by the loss of skeletal muscle mass. This damage can cause the patient’s exercise capacity to be limited, so adequate attention should be paid clinically.
Inductores de lágrimas: andrógenos y gammaglobulinas humanas Tears inducers: androgens and human gammaglobulinas
María Nila Santos Lagresa,Nereyda Martínez Suárez,Deysi Vilches Lescaille,Caridad Marisela Santos Lagresa
Revista Cubana de Oftalmolog？-a , 2000,
Abstract: Se comparan las respuestas terapéuticas en pacientes con diagnóstico de Síndrome de Sj gren que padecen de queratoconjuntivitis seca resistentes a los tratamientos tradicionales de lágrimas artificiales, lentes y otros, en dos grupos de pacientes de 18 y 32 casos con tratamientos de gammaglobulina humana: intacglobín (100 mg por kilo de peso cada 15 días por vía subcutánea interescapular por 3 meses) y andrógenos de depósito (100 mg cada 15 días por vía im durante 3 meses). Se evaluaron los niveles de inmunoglobulinas IgG, IgA, IgM e IgE, recuento de células sanguíneas factor reumatoideo, proteína C reactiva y estudio microbiológico. Ambas terapéuticas muestran una mejoría estadísticamente significativa p < 0,001 en los resultados obtenidos en la prueba de Shirmer I y en la negativización de las lesiones corneales valoradas en lámpara de hendidura después de tinción con fluorescencia. Se plantea las ventajas del uso de gammaglobulinas a causa de las contraindicaciones en el uso de andrógenos. Therapeutical responses are compared in patients diagnosed of Sj gren syndrome, presenting with keratoconjunctivitis sicca resistant to traditional treatments of artificial tears, lenses and others in two groups of patients (18 and 32 cases) treated with human gammaglobulin: intacglobin (100 mg/body weight every 15 days in a intercapsular subcutaneos way for 3 months), and depot androgens (100 mg every 15 days in an intramuscular way for three months). Level of IgG, IgA, IgM, and IgE immunoglobulins, count of blood cells-rheumatoid factor, C-reactive protein, and microbiological study. Both treatments show an significant statistically improve p < 0,001 in results obtained in Shirmer I test, and in negative corneal injuries, assessed using slit lamp after fluorescein staining. We propose advantageous use of gammaglobulins because of contraindications on utilization of androgens.
Primary Sjogren Syndrome: Case report
Eylem Yaman Pinarci,Aysel Pelit,Duygu Bozkirli,Emine Tuba Canbolat
Cukurova Medical Journal , 2013,
Abstract: The importance of systemic evaluation of dry eye patients and choosing appropriate treatment based on the severity of disease were emphasized with this case. 48 years old woman complained about decreased vision, burning, itching in both eyes which got worse over the years, for about 20 years. Schirmer I test value was 0 mm/5min in both eyes. Slit lamp examination revealed filamentary keratitis in both eyes. Anti-Ro/ SSA, anti-La/ SS-B antibodies and salivary gland biopsy for Sjogren syndrome were positive. Temporary punctal occlusion and oral hydroxychloroquine were added to her treatment. After 10 days, her overall dry eye condition improved and permanent punctual plugs were inserted in both lower puctums.Dry eye patients should be evaluated systemically and severity of disease should be considered before treatment is started. Addition to topical application of artificial tears, punctal occlusion may be a proper option in dry eye patients with Sjogren syndrome. [Cukurova Med J 2013; 38(4.000): 818-822]
Sj？gren’s Syndrome Associated with Fanconi’s Syndrome and Osteomalacia
Jorge O. Gutierrez,Luis A. Zurita,Maria F. Zurita
- , 2018, DOI: 10.12659/AJCR.907503
Abstract:
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