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OALib Journal期刊

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Clinical aspects of the temporal arteritis
Palheta Neto, Francisco Xavier,Carneiro, Kássia Lima,Rodrigues Junior, Orlando Maciel,Rodrigues Junior, Adilson Góes
International Archives of Otorhinolaryngology , 2008,
Abstract: Introduction: The Horton's disease, or temporal arteritis, is the most common autoimmune systemic vasculitis in adults, especially the old-aged. Objective: To review the literature about the several aspects of the Horton's disease, and confirm the otorhinolaryngologic clinical manifestations. Method: The study searched online databases such as EMedicine, Encyclopedia of Medicine, FindArticles, LILACS, MEDLINE, Merck Manuals On-Line Medical Library and Scielo, and applied to the search the terms: Horton's disease, Temporal Arteritis and Giant Cells Arteritis, for articles published between 1996 and 2008. Literature's Review: The disease's clinical manifestations start after 50 years old, and it's more frequent near 72 years old. The intense headache, temporal tumefaction, mandibular claudication and visual loss are the main signals and symptoms. There may occur dysacusis, necrosis of the tongue and odynophagia. Considerations: Lots of aspects of the Horton's disease do not have their due elucidation and, even being a disease that affects many adults, it doesn't have deep investigations in great quantity. A better understanding of this disease will lead to the increment of cure possibilities and reduction of morbidity in the patients, especially in ophthalmologic and otorhinolaryngologic areas.
Horton’s Disease in the Internal Medicine Department of the Donka University Hospital (Guinea-Conakry): Epidemiological, Clinical, Therapeutic and Evolutionary Profile  [PDF]
Thierno Amadou Wann,Mamadou Lamine Yaya Bah,Djibril Sylla,Aissatou Diallo,Mamadou Diakhaby,Mamadou Aliou Kante,Amadou Kake
Open Access Library Journal (OALib Journal) , 2025, DOI: 10.4236/oalib.1114119
Abstract: Introduction: Horton’s disease, also called giant cell arteritis (GCA), is an inflammatory arteritis affecting large and medium caliber arteries with predilection for the cranial branches of the arteries originating of the aortic arch and in particular the external carotid, as well as for ophthalmic arteries. It was first reported in 1890 by Hutchinson. It generally concerns the elderly with a slight female predominance, its incidence is estimated at 17.8/100,000 and 46/100,000, respectively, among subjects over 50 and 70 years old. The typical form realizes a symptomatic tripod associating headaches, more or less febrile alteration of the general state and rheumatic manifestations. THE criteria for classification of MH were determined in 1990 when of the consensus conference of the American College of Rheumatology. Temporal artery biopsy remains an essential diagnostic test. The objective of this study was to determine the prevalence of Horton’s disease in the internal medicine department of the Donka University Hospital (Guinea-Conakry). Materials and Methods: this was a retrospective study of the records of patients monitored and treated for Horton’s disease in the internal medicine department of the Donka University Hospital (Guinea-Conakry) between January 2017 and December 2022. The diagnosis of Horton’s disease was made according to the ACR criteria. Results: we included 6 patients (4 women and 2 men, is a sex ratio of 0.5). The average age of patients at diagnosis was 70 years. The main clinical manifestations found were headaches, especially temporal headaches in all patients (6 cases or 100%), followed by deterioration of general condition in 4 patients (66.66%), pseudo-polyarthritis rheumatica in 3 patients (50%) and prolonged fever in 3 patients (50%). Two patients (33.33%) had uveitis, scalp hyperesthesia and jaw claudication. Of the four patients who had a biopsy of the temporal artery, the appearance of giant cell arteritis was found in 100% of cases. Therapeutically, boluses of solumedrol (500-1000 mg/day for 3 days) were administered and the evolution was favorable in 4 patients (66.66%). Conclusion: Horton’s disease is a less diagnosed pathology due to atypical signs, temporal headaches can be the signs suggesting the disease. Eye damage is the serious complication of this condition. Biopsy of the temporal artery helps confirm the diagnosis by highlightingan infiltrationgiant cell granulomatous. Management uses corticosteroid therapy.
Giant cell arteritis: A rare cause of posterior vasculitis
Marilita M Moschos, Yan Guex-Crosier
Clinical Ophthalmology , 2009, DOI: http://dx.doi.org/10.2147/OPTH.S4643
Abstract: nt cell arteritis: A rare cause of posterior vasculitis Original Research (5048) Total Article Views Authors: Marilita M Moschos, Yan Guex-Crosier Published Date December 2008 Volume 2009:3 Pages 111 - 115 DOI: http://dx.doi.org/10.2147/OPTH.S4643 Marilita M Moschos1, Yan Guex-Crosier2 1Department of Ophthalmology, University of Athens, Greece; 2Jules Gonin Eye Hospital, University of Lausanne, Switzerland Purpose: To report three cases of posterior vasculitis associated with subacute giant cell arteritis (GCA). Methods: Three patients with decreased vision underwent complete ophthalmologic examination and fluorescein angiography. Results: All patients presented posterior vasculitis. Patient 1 had an erythrocyte sedimentation rate (ESR) of 38 mm/hr and a C-reactive protein (CRP) of 28mg/L. Patient 2 and 3 had an ESR of 104 and 95 mm/hr and a CRP of 42 and 195 mg/L accordingly. Diagnosis was established by temporal artery biopsy. Resolution was observed after systemic prednisolone therapy. Conclusion: GCA should be suspected when posterior vasculitis and relatively high ESR and CRP are present.
Giant cell arteritis: the importance of immediate and appropriate diagnosis and treatment for better prognosis
Pacella F, Mazzeo F, Giorgi D, Cerutti F, Impallara D, Cuozzo G, Soldini M, Pacella E
Clinical Ophthalmology , 2012, DOI: http://dx.doi.org/10.2147/OPTH.S24572
Abstract: nt cell arteritis: the importance of immediate and appropriate diagnosis and treatment for better prognosis Case report (1966) Total Article Views Authors: Pacella F, Mazzeo F, Giorgi D, Cerutti F, Impallara D, Cuozzo G, Soldini M, Pacella E Published Date June 2012 Volume 2012:6 Pages 909 - 913 DOI: http://dx.doi.org/10.2147/OPTH.S24572 Received: 26 July 2011 Accepted: 15 December 2011 Published: 13 June 2012 Fernanda Pacella,1 Francesco Mazzeo,1 Dario Giorgi,1 Francesco Cerutti,1 David Impallara,1 Giovanni Cuozzo,1 Maurizio Soldini,2 Elena Pacella1 1Department of Ophthalmology, 2Service Detachment of Internal Medicine and Cardiology, Department of Ophthalmology, Sapienza University, Rome, Italy Abstract: This article describes the case of a 68-year-old patient suffering from giant cell arteritis (also known as Horton’s arteritis or temporal arteritis). The patient came to our attention due to a large and sudden visual loss caused by the occlusion of major retinal arteries. The patient had neuralgic pain in the face. The next day, for a thorough examination, the patient went to the day hospital with a further worsening of the visual loss which required immediate admission to the ophthalmological ward for hospitalization lasting 10 days. During the observation period it was difficult to make an instant diagnosis due to the absence of clinical signs or diagnostic tests for Horton’s arteritis. Only after the third day of hospitalization, when corticosteroid therapy was undertaken following the appearance of significant systemic symptoms, did the patient begin to show a gradual improvement in overall clinical status. The case highlights the difficulty in making a rapid diagnosis of giant cell arteritis and the efficacy of early steroid therapy in this vascular autoimmune disease that otherwise may result in irreversible functional and debilitating systemic damage.
The association of Crohn’s disease with celiac disease  [PDF]
Iliass Charif, Mohamed El Abkari, Adil Ibrahimi, Mounia El Yousfi, Mounia El Yousfi
Open Journal of Gastroenterology (OJGas) , 2012, DOI: 10.4236/ojgas.2012.24036
Abstract: We report two cases of a man and a woman whose association of Crohn’s disease (CRD) and celiac disease (CD) was evident and significant. The characteristic of our patients was the young age of discovery, and the localization of the CRD which was different in the two cases: colic localization in the woman and ileal stenosing in the man. The diagnosis of MCO was confirmed by the histological study of the jejunal biopsies in both cases and by serologies (anti-gliadines Antibody) in one case. Through these two observations, we insist on the singularity of the association of the celiac disease to the Crohn’s disease and on the complex etiopathogenesis of CRD which could have common points with that of CD. This fact can help us to understand more the two diseases and thereafter master their management.
Análisis de una serie de 55 pacientes con arteritis de células gigantes confirmada por biopsia
Bustamante Maldonado,E.; Marí Alfonso,B.; Monteagudo Jiménez,M.; Casanovas Martínez,A.; Jordana Comajuncosa,R.; Tolosa Vilella,C.; Oristrell Salvá,J.;
Anales de Medicina Interna , 2004, DOI: 10.4321/S0212-71992004001000002
Abstract: introduction: our main aim with this study is to establish the epidemiologic and clinical features, treatment response and complications of a group composed of 55 patients with biopsy proven temporal arteritis in a local hospital. material and methods: restrospective study based on clinical records revision of patients diagnosticated of giant cell arteritis (gca) made by temporal artery biopsy between 1989 and 2001. results: the aproximated annual incidence of gca in our area is 4.1 cases per 100.000 persons over the age of 50. the mean age at diagnostic was 74 years and the 78,2% were women. the most common symptom at diagnostic was headache (81,5%) followed by systemic manifestations (74,1%) and later we found jaw claudication (32,7%), visual impairment (30,2%), isquemic manifestations (17%). polimyalgia rheumatica was asociated to gca in 49,1% of cases. the temporal artery explorations was abnormal in the 76,9% of patients. the mean initial dose of corticoids was 69 mg prednisone per day, with a half dose reduction time of 3,5 months. in spite of that, 24,1% of patients relapsed during the first year. the 38% of patients did some complications during the corticosteroid treatment. the esr was lower 50 mm in 12,7% of patients; it was anaemia in the 37,7% and thrombocitosis in 32,1%. in these last patients we detected a relation between thrombocitosis and specific visual impairment. conclusions: the incidence of gca in our area is low. the results of our serie aren't different from others publicated before in clinical manifestations, there is a prevalence of female sex and there is a relation between specific visual impairment and the presence of thrombocitosis.
A Unique Case? Darier’s Disease Presented as Porcupine-Like Appearance and the Observation on Acitretin Treatment  [PDF]
Xi-Bao Zhang, Chang-Xing Li, Xue-Mei Li, Yu-Qing He, Xiao Xu, Quan Luo
Journal of Cosmetics, Dermatological Sciences and Applications (JCDSA) , 2012, DOI: 10.4236/jcdsa.2012.23027
Abstract: Dyskeratosis follicularis (Darier’s disease, DD) is rare autosomal dominant disease characterized by hyperkeratotic papules that coalesce into plaques and occur primarily in seborrheic or intertriginous areas. Associated findings include nail abnormalities. A 3-year-old boy presented with porcupine-like appearance for 2 years. The lesion from the back was taken for light microscopy and electron microscopy. He was treated with acitretin (0.31 mg/d to 0.66 mg/d) for 8 years. Light microscopy and electron microscopy showed that the typical features of DD. The patient show good respond to the treatment. During 8 years treatment, the patient had dry mouth and pruritus. The skeletal abnormalities didn’t happen in the patient. The serum lipid profile, liver function and renal function within normal lever after treatment. Our findings showed that porcupine-like appearance is a unique pattern of DD. Acitretin may be a useful therapeutic agent in children with DD and less likely to cause skeletal problems.
Cognitive assessment in Alzheimer’s disease  [PDF]
Mario A. Parra
Advances in Alzheimer's Disease (AAD) , 2013, DOI: 10.4236/aad.2013.24016
Abstract: Cognitive assessment in Alzheimer’s disease
Letter to the Editor  [PDF]
Lin Shi
Advances in Alzheimer's Disease (AAD) , 2013, DOI: 10.4236/aad.2013.23010
Abstract: Letter; Alzheimer’s Disease
Parkinson’s disease: Is there a light at the end of a tunnel?  [PDF]
Andrei Surguchov
Advances in Parkinson's Disease (APD) , 2013, DOI: 10.4236/apd.2013.24022
Abstract: Parkinson’s disease is the second most common neu- rodegenerative disorder after Alzheimer disease affecting 1% - 2% in people >60 years old and 3% - 4% in people >80.
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