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Thermal Analysis, Antioxidant and in vitro Antimicrobial Activity of Palladium(II) Complexes with N,Na？2- Ethylenediamine Bidentate Ester Ligands
Jelena M Maskovic,Natalia V Loginova,Pavle Z Maskovic,Tatyana V Koval’chuk
- , 2018,
Abstract: Palladium (II) complexes (1-4) with bidentate N,N’-ligands, O,O'-dialkyl esters (R=ethyl, n-propyl, n-butyl and n-pentyl), of (S,S)-ethylenediamine-N,N’-di-2-(4-methyl)pentanoic acid (S,S-eddp) (L1？2HCl-L4？2HCl) were prepared. The ligands and its complexes were tested for their in vitro antimicrobial and antioxidant activities. The antimicrobial activity was tested using broth dilution procedure for determination of the minimum inhibitory concentration (MIC). The MICs were determined for 6 selected indicator strains. The Pd (II) complex with the n -Pe group in ester chain displayed the strongest antimicrobial activity among the all tested compounds. The results showed that the ligand with the n -Bu group in ester chain possessed the highest total antioxidant D°ctivity and antioxidant activity at the level of the DPPH and ABTS radicals. The IC50 values determined were: 12.89 ± 1.75 to 8.29 ± 0.64 μg/ mL for DPPH free radical scavenging activity and 22.46 ± 1.68 to 14.46 ± 1.68 for ABTS radical scavenging assay. Also, the results of thermal decomposition have been discussed
Determination of the total content of diterpene glycosides in Stevia rebaudiana plant by the method of direct potentiometry
Maria O. Mironyak,Natalia V. Lutsenko,Oksana V. Labyak,Olena V. Volnyanska
- , 2016,
Abstract: We have investigated the reaction of diterpene steviol glycosides with heteropolyanion of Keggin structure of 12- molybdophosphoric acid by UV and IR spectroscopy. The associative nature of the interaction was confirmed. The resulting slightly soluble associate was used as electrode active substance in plasticized membranes of ion-selective electrodes sensitive to steviol glycosides. The developed new film ion-selective electrodes, being sensitive to stevioside, have satisfactory electrode characteristics. They are proposed for the quantitative determination of steviol glycosides in extracts, food products and cosmetics by direct potentiometry. A method for the quantitative determination of diterpene steviol glycosides in extracts and industrial output by direct potentiometry has been developed. The developed method meets all the requirements of modern analysis - it is simple, express, safe and affordable. It has sufficient selectivity, accuracy, and sensitivity
Proteomic Profiling of High-grade Glioblastoma Using Virtual experimental 2DE
Maria A Maynskova,Michael V Filatov,Natalia L Ronzhina,Natalia V Belyakova,Olga A Kleyst,Olga K Legina,Rimma A Pantina,Stanislav N Naryzhny,Svetlana E Novikova,Victor G Zgoda
- , 2016, DOI: 10.4172/jpb.1000402
Abstract: Identification and quantitative analysis of different proteoforms (protein species) presented in a cell line generated from high grade glioblastoma was performed using two-dimensional electrophoresis (2DE), mass spectrometry (ESI LC-MS/MS), and immunodetection. A 2DE protein map containing an extensive data set comprising 937 spots with 1542 unique protein identifications (proteoforms) of 600 genes was obtained. Additionally, another set of experiments was performed where 16012 proteoforms coded by 4050 genes were identified by MS/MS according to their position in 96 gel sections (pixels). A special attention has been paid to the proteins that are the potential biomarkers of glioblastoma. The list of these biomarkers was compiled from literature. Next, we generated the graphs with theoretical and experimental information about proteoforms coded by the same gene. Such a virtualexperimental representation allowed better visualization of the state of these gene products. Many proteins, potential biomarkers of glioblastoma as well, are characterized by high numbers of protein species. We assume that these species could be a potential source of highly specific biomarkers of glioblastoma.
Hepatoprotective Study on Aegle marmelos Leaves Extract against Staphylococcus aureus Intoxicated Albino Rats
R. Gowri
- , 2015,
Abstract: Objectives: The Liver is the largest organ in the body carrying out most of the biochemical synthesis and secretary functions. Living in a world of inadequately controlled environment, pollution and expanding therapy with potent drugs, it is continuously exposed to variety of xenobiotics and therapeutic agents resulting in its structural or functional damage. In an attempt to establish its pharmacological potential, we studied the Hepatoprotective activity of alcohol extract of Aegle marmelos obtained via extraction of air-dried leaves. Methods: The rats were administered the ethanol extract (dose range of 100 mg/kg) orally for 15 days. The animals were randomly divided in to four groups, each containing three animals. They were subjected to the intraperitoneal injection of bacterial suspension at a dose of 5 X 106 CFU/0.1 mL once in every three days. Then the animals were treated with the alcoholic extract of Aegle marmelos daily for 15 days in physiological saline at concentration of 100mg/kg of body weight. The Silymerin (25mg/kg) was used as the standard control. Results: At a dose of 100 mg/kg, the extract produced no sign of toxicity in rats. The extract exhibited significant (p < 0.05) dosedependent Hepatoprotective activity for the Staphylococcus aureus induced model. In alcoholic extract of treated groups there was statistical significant decrease in the levels of serum bilirubin, serum glutamate oxaloacetate transminase (SGOT), serum glutamate pyruvate transminase (SGPT) and serum alkaline phosphatase (SALP) as compared to the hepatotoxic group. In the liver by a significant reduction in the activity levels of superoxide dismutase, catalase, glutathione peroxidase, gluthaione-s-transferase, glutathione reductase and also reduced glutathione content were observed in the liver of S. aureus intoxicated rats over the control. Conclusion: The alcoholic extracts of the leaves of Aegle marmelos possess Hepatoprotective activity, Anti stress, anti oxidant properties that may be due to cytoprotective mechanism
Optimization of the SDS-PAGE gel slicing approach for identification of human liver microsomal proteins via MALDI-TOF mass spectrometry
Aleksey L Chernobrovkin,Alex,Andrey V Lisitsa,Irina I Karuzina,Natalia A Petushkova,Oksana P Trifonova,Olesya V Larina,Yulia S Kisrieva,er I Archakov
- , 2012, DOI: 10.4172/jpb.1000211
Abstract: Proteomics often exploits sequential cutting of the SDS-PAGE gel lane into slices with subsequent identification of proteins by peptide mass fingerprinting (PMF). In this paper, the influence of slice thickness on protein identification was investigated. Following the separation of the human liver microsomal fraction, the 37 to 75 kDa range of the gel lane was cut into 20 or 40 slices of 0.5 mm and 0.25 mm thickness, respectively. Identification of proteins after trypsinolysis was performed by MALDI-TOF mass spectrometry. A twofold reduction of slice thickness did not influence the number of peaks in PMF-spectra. It was established that at a tolerance of 0.15 Da the number of identified proteins in the 40 slices series exceeded by more than twofold the number of identifications in 20 slices series. It was shown that the decrease of slice thickness leads to a considerable enhancement of peptide peak’s intensity and, also, to the changes of PMF-spectra which resulted gaining additional peptides for enrichment of sequence coverage
最简方案框架下动结式的核心及句法表征
The Heads and Syntactic Representations of Chinese V-R Compounds within the Framework of Mi-nimalist Program  [PDF]
付晨旭, 周长银
Modern Linguistics (ML) , 2013, DOI: 10.12677/ML.2013.12008
Abstract:
动结式的核心问题一直是汉语研究的一大热点。近二三十年来的研究主要是从语义核心和形态句法特征方面展开的。本文认为，所有核心都应具有决定整体结构范畴归属的特征，决定动结式范畴归属的核心则是其形态句法核心。本文认同将动结式分为同指和异指两种类型的观点，并在Chomsky最简方案(MP)框架下通过轻动词v这一功能语类，在确定动结式功能核心和词汇核心的同时，还从句法结构上对这两类动结式进行了表征。
What is the head of a Chinese V-R compound is a longstanding hot topic in Chinese study. In the last 20 or 30 years, the research on this topic has been done either from the perspective of semantic head or from morphosyntactic features. This paper holds that a head should have the feature of determining the whole construction in which it is in and that a head should be morphosyntactic. Following the view that Chinese V-R compounds can be divided into two types, namely homo-referential and hetero-referential, this paper aims to fix the head of a Chinese V-R compound through the functional head v within the framework of Minimalist Program and to provide the syntactic representations for these two types of Chinese V-R compounds.
The rupture of the diaphragm: Case report
Eddy Oleko Ekuke
- , 2018,
Abstract: Diaphragmatic ruptures represent a rare but potentially serious clinical entity that is often integrated into polytrauma. We report a case of left diaphragmatic rupture, discovered twenty days after an accident on the public highway. For the diagnosis, it is necessary to insist on the body scan, whose sensitivity is undoubtedly less than that of other more specific examinations, but which is easily interpretable and accessible in most emergency centers. The order of surgical management is taken at clinical examination, and before the existence of an abdominal emergency
Serine Exoproteinases Secreted by the Pathogenic Fungi of Alternaria Genus
Alexis V Sofyin,Boris Ts Zaitchik,Lyudmila Yu Kokaeva,Marina A Pobedinskaya,Natalia N Kudryavtseva,Sergey N Elansky,Tatiana A Valueva
- , 2015, DOI: 10.4172/2157-7471.1000272
Abstract: Fungi of different species of the Alternaria genus isolated from potato or tomato plants in several Russian regions excreted proteolytic enzymes during the growth in the medium containing thermostable proteins of pea and carrot. The growing of fungi in such medium can be considered as a model system for studying the infection process. It has been shown increased production of proteolytic enzymes that included serine proteases belonging to the subtilisin and trypsin families. In most isolates, the proteolytic enzymes production has been observed during the exponential phase of growth. The data obtained demonstrated that the exoproteinase activity depended on the natures of both the isolate and its host plant, but it was defined by the isolate's genotype predominantly. The data also clearly demonstrated a phenomenon of exceeding of the exoprotease activity, especially trypsin-like, in the tomato isolates in comparison with that in the potato isolates. They indirectly indicate the possibility of pathogenic specialization of Alternaria spp. in the Solanaceae that is in accordance with the existence of intra- and inter-specific variations in species of Alternaria.
Functional promiscuity in a mammalian chemosensory system: extensive expression of vomeronasal receptors in the main olfactory epithelium of mouse lemurs
Philipp Hohenbrink,Silke Dempewolf,Nicholas I. Mundy,Ute Radespiel
Frontiers in Neuroanatomy , 2014, DOI: 10.3389/fnana.2014.00102
Abstract: The vomeronasal organ (VNO) is functional in most terrestrial mammals, though progressively reduced in the primate lineage, and is used for intraspecific communication and predator recognition. Vomeronasal receptor (VR) genes comprise two families of chemosensory genes (V1R and V2R) that have been considered to be specific for the VNO. However, recently a large number of VRs were reported to be expressed in the main olfactory epithelium (MOE) of mice, but there is little knowledge of the expression of these genes outside of rodents. To explore the function of VR genes in mammalian evolution, we analyzed and compared the expression of 64 V1R and 2 V2R genes in the VNO and the MOE of the grey mouse lemur (Microcebus murinus), the primate with the largest known VR repertoire. We furthermore compared expression patterns in adults of both sexes and seasons, and in an infant. A large proportion (83% – 97%) of the VR loci was expressed in the VNO of all individuals. The repertoire in the infant was as rich as in adults, indicating reliance on olfactory communication from early postnatal development onwards. In concordance with mice, we also detected extensive expression of VRs in the MOE, with proportions of expressed loci in individuals ranging from 29% to 45%. TRPC2, which encodes a channel protein crucial for signal transduction via VRs, was co-expressed in the MOE in all individuals indicating likely functionality of expressed VR genes in the MOE. In summary, the large VR repertoire in mouse lemurs seems to be highly functional. Given the differences in the neural pathways of MOE and VNO signals, which project to higher cortical brain centers or the limbic system, respectively, this raises the intriguing possibility that the evolution of MOE-expression of VRs enabled mouse lemurs to adaptively diversify the processing of VR-encoded olfactory information.
PERFORMANCE ANALYSIS OF ON-DEMAND ROUTING PROTOCOLS FOR VEHICULAR AD-HOC NETWORKS
A. Shastri,R. Dadhich,Ramesh C. Poonia
International Journal of Wireless & Mobile Networks , 2011,
Abstract: Vehicular Ad Hoc Networks (VANETs) are a peculiar subclass of mobile ad hoc networks that raise anumber of technical challenges, especially from the point of view of their mobility models. Currently, thefield of VANETs has gained an important part of the interest of researchers and become very popular.More specifically, VANETs can operate without fixed infrastructure and can survive rapid changes in thenetwork topology. The main method for evaluating the performance of routing protocols for VANETs byNetwork Simulator-2.34. This paper is subjected to the on-demand routing protocols with identical loadsand evaluates their relative performance with respect to the two performance context: average End-to-End delay and packet delivery ratio. We investigated various simulation scenarios with varying pausetimes, connections and no. of nodes particularly for AODV and DSR. We will also discuss briefly aboutthe feasibility of VANETs in respect of Indian automotive networks.
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