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匹配条件： “Disseminated Intravascular Coagulation (DIC)” ，找到相关结果约1000条。
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Clinical Investigation of Coagulation Markers for Early Detection of Sepsis
Takamitsu Masuda,Tomohisa Shoko,Yoshizumi Deguchi
Clinical and Applied Thrombosis/Hemostasis , 2018, DOI: 10.1177/1076029618762473

Abstract: Disseminated intravascular coagulation (DIC) often complicates sepsis, and its early treatment is crucial for improving patient outcomes. Coagulation markers may enable earlier diagnosis of DIC. The purpose of this study was to evaluate whether the risk of DIC onset can be predicted using coagulation markers. Patients who showed symptoms of systemic inflammatory response syndrome ≥2 and the quick Sequential Organ Failure Assessment score ≥2 points were investigated. All blood samples collected from the time of hospital admission to 7 days postadmission were investigated. Patients were classified according to time of DIC onset (1) no DIC group (not DIC developed), (2) pre-DIC group (DIC onset >24 hours after admission), (3) DIC group (DIC onset at time of the admission) and according to cutoff values of coagulation markers, High group and Low group. Statistical differences were analyzed by log-rank test, Kruskal-Wallis rank test, and Friedman test. A total of 107 patients were enrolled in the study. Soluble fibrin (SF), plasminogen activator inhibitor (PAI)-1, and d-dimer levels were significantly increased even under pre-DIC conditions. Japanese Association for Acute Medicine (JAAM) DIC scores increased significantly over time in the High SF group (≥31.0 μg/mL) and High PAI-1 group (≥49.0 ng/mL), while JAAM DIC scores in the Low SF group remained ≤3 until day 7. We proposed the cutoff values of SF as 31 μg/mL to detect early phase of DIC. Soluble fibrin might be useful not only to predict DIC but also to exclude a diagnosis of DIC

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MANAGEMENT OF DISSEMINATED INTRAVASCULAR COAGULATION BY AGGRESSIVE COMPONENT THERAPY: A CASE REPORT
V. Bangal,Kwatra A,Gulati P
Pravara Medical Review , 2010,

Abstract: Disseminated intravascular coagulation is a life threatening complication of severe postpartum hemorrhage. It results from washing out of all important procoagulants. A case of hemorrhagic shock following atonic postpartum hemorrhage is reported. She was treated by emergency obstetric hysterectomy and aggressive blood and blood component therapy.

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Disseminated Intravascular Coagulation at Diagnosis in Acute Myeloblastic Leukaemia [PDF]
Masba Uddin Chowdhury, Masuda Begum, Md. Rafiquzzaman Khan, Amin Lutful Kabir, Shafiqul Islam, Khushbun Nahar Layla, Fahmida Ahamed, Jamal Uddin Tanin
Journal of Biosciences and Medicines (JBM) , 2021, DOI: 10.4236/jbm.2021.910011

Abstract: Background: Disseminated Intravascular Coagulation (DIC) is a life threatening complication frequently observed in acute leukemia. Among the morphological varieties of Acute Myeloid Leukaemia (AML), Acute Promyelocytic Leukaemia (APL) is well established to cause DIC. But there have been reports noted that abnormal DIC parameters also commonly observed in the patients with non-APL AML. This study evaluated the DIC parameters & DIC score according to International Society of Thrombosis and Haemostasis (ISTH) in newly diagnosed non-APL AML patients. Materials and Methods: This cross-sectional observational study was conducted in the Department of Haematology, BSMMU, Dhaka, Bangladesh. 48 newly diagnosed non-APL AML patients were enrolled. Platelets count was measured by auto analyzer (Sysmax XT 2000i/Pentra ABX-120DX) as well as checked manually. Prothrombin time, fibrinogen, D-Dimer were measured using STAGO Coagulation analyzer. The ISTH-DIC scoring system was used to calculate DIC score. The statistical analysis was carried out using the Statistical Package for Social Sciences version 24.0 for Windows. Chi-Square test & Fisher exact test was used for categorical variables. Unpaired t-test was used to compare mean between groups. For all statistical tests, p-value less than 0.05 was considered as statistically significant. Results: By analyzing 48 newly diagnosed patients with non-APL AML, found that DIC developed in 14.6% patients at presentation. Among the DIC parameters, PT and D-dimer were significantly higher in patients presented with DIC. Patients with DIC exhibit lower expression of CD117, CD34, HLA-DR and statistically significant association with negative expression of HLA-DR (p-value 0.034). No significant association was found between presence of DIC and age, gender, bleeding at presentation, morphological type, WBC count or peripheral blast percentage. Conclusion: Abnormalities of DIC parameters in common in patients with AML. A significant portion of patients with DIC have no apparent symptom or bleeding. So, routine screening of DIC parameter at presentation is recommended for early diagnosis & effective management of DIC.

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Proposal for new diagnostic criteria for DIC from the Japanese Society on Thrombosis and Hemostasis
DIC subcommittee of the Japanese Society on Thrombosis and Hemostasis,Hideo Wada,Hidesaku Asakura,Hoyu Takahashi,Kazuo Kawasugi,Kohji Okamoto,Seiji Madoiwa,Toshimasa Uchiyama,Yutaka Eguchi
- , 2016, DOI: 10.1186/s12959-016-0117-x

Abstract: Disseminated intravascular coagulation (DIC) is a serious disease that, in the presence of underlying disease, causes persistent, generalized, marked coagulation activation. Early treatment based on an appropriate diagnosis is very important for improving patients’ prognosis, to which end diagnostic criteria play a key role. Several criteria have been proposed, but each has its strengths and weaknesses, and improved criteria are needed. Widespread use of coagulofibrinolytic markers has elucidated that the pathology of DIC differs greatly as a function of the underlying disease. Thus, discriminating use of DIC diagnostic criteria that take underlying diseases into account is important

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A retrospective study of 296 cases of intra uterine fetal deaths at a tertiary care centre
Neetu Singh,Kiran Pandey,Neena Gupta,A K Arya
International Journal of Reproduction, Contraception, Obstetrics and Gynecology , 2013, DOI: 10.5455/2320-1770.ijrcog20130606

Abstract: Background: To identify the risk factors and to streamline preventive and management protocols for IUD. Methods: This was a retrospective study from January 2011 to December 2012 which was conducted at G.S.V.M. Medical College, Kanpur. IUD was defined as fetal death beyond 20 weeks of gestation and/or birth weight > 500g. Maternal and fetal records were analysed. Mode of delivery and associated complications were studied. Results: Total number of deliveries were 7310.Incidence of IUD at our centre was 40 per 1000. 55.73% were antepartum and 11.06% were intra partum. In 33.44% cases, no causes were identified. Among the identifiable causes, very severe anemia (16.55%) and hypertensive disorders (10.81%) were most common followed by placental causes (12.16%).Congenital malformations were responsible for 9.45% cases .Induction was done in 151 patients,111 patients had spontaneous onset of labour and caesarean section was done in 34 patients. The most devastating complication of IUD was DIC found in 14 patients (3.71%). Conclusions: The present study is an effort to compile a profile of maternal, fetal and placental causes culminating to IUD at our centre. This emphasizes the importance of proper antenatal care and identification of risk factors and its treatment. Institutional deliveries should be promoted to prevent intrapartum fetal deaths .A substantial number of IUD are still labeled as unexplained, hence cannot be prevented. Decrease in the incidence of IUD would significantly reduce the perinatal mortality. [Int J Reprod Contracept Obstet Gynecol 2013; 2(2.000): 141-146]

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Disseminated intravascular coagulation with the fibrinolytic phenotype predicts the outcome of patients with out-of-hospital cardiac arrest
Atsushi Sawamura,Kenichi Katabami,Kunihiko Maekawa,Mineji Hayakawa,Satoshi Gando,Takeshi Wada,Yuichi Ono
- , 2016, DOI: 10.1186/s12959-016-0116-y

Abstract: We tested the hypothesis that disseminated intravascular coagulation (DIC) during the early phase of post-cardiopulmonary resuscitation (CPR) is associated with systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS) and affects the outcome of out-of-hospital cardiac arrest (OHCA) patients

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A prospective study of bleeding neonates: Clinical presentation, aetiological profile, immediate outcome and short term follow up.
Brajesh kumar Rai,Divya M,Kripanath M,Swarnim S
- , 2017,

Abstract: Background and objective: Bleeding in neonates is a significant cause of morbidity and mortality in the neonatal period. The early identification of bleeding and its cause is very important for the appropriate management and for prognostication. The relative paucity of Indian studies on bleeding in newborns prompted us to do this study looking at Clinical Presentation, aetiological Profile, Immediate Outcome, and Short Term Follow up of Bleeding Neonates. Methods: This prospective study was done in NICU of a tertiary care hospital in Bihar, between February 2013 to august 2014. A detailed history, family history, perinatal problems and thorough clinical assessment, relevant investigations were done when required, for all the 70 neonates who had bleeding manifestations out of 1803 admissions, during the same period. Immediate outcome, i.e., survival or death and developmental assessment at 6 months of age in the survivors was done. Results: The incidence of bleeding neonates was 3.88%. Preterm infants had a higher incidence of bleeding 18.57% (p<0.001).Very low birth weight babies had an increased risk of bleeding (p<0.01). Out born babies were at higher risk of bleeding 88% (p<0.01). 71.43% of the neonates had bleeding manifestation between the second and seventh day of life. Disseminated intravascular coagulation constituted the major cause of bleeding (55.7%). Septicemia with DIC contributed 65.22% of cases of death. The outcome of early and classic VKDB was excellent whereas it was dismal for late VKDB. Vitamin K prophylaxis has an important role in the prevention of VKDB

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Malignancies Presenting as Disseminated Intravascular Coagulation (DIC)
Wasay Kabir
- , 2018, DOI: 10.5923/j.ijim.20180703.02

Abstract: The objective of this study was to describe malignancies presenting as Disseminated Intravascular Coagulation (DIC). The prognosis of Disseminated Carcinomatosis of the Bone Marrow (DCBM) caused by solid tumors which is often accompanied by Disseminated Intravascular Coagulation (DIC is generally very poor. The diagnostic procedures to find the underlying cause of DIC ended up in the discovery of metastatic cancer. Disseminated Carcinomatosis of Bone Marrow (DCBM) is a condition in which the tumour cells metastases diffusely invade the bone marrow, and is frequently accompanied by Disseminated Intravascular Coagulation (DIC). While prostate, lung, breast and stomach malignancies are the most prevalent non-hematological malignancies to metastasize frequently to the bone marrow, pancreatic cancer is a malignancy that rarely metastasizes to the bone marrow. The present study describes 3 patients with DCBM one with pancreatic cancer, second with breast cancer and a third one with gastric cancer. Their laboratory workup confirmed the presence of chronic DIC. Bone marrow biopsies were done which revealed metastatic adenocarcinoma. So PET-CT scans were done which showed metabolically active multiple skeletal lesions. IHC of bone marrow cells was sent for finding primary which showed likely involvement of primary (pancreatobiliary, breast, gastric) system. DCBM derived from solid cancer with DIC has a very poor prognosis and despite all treatments these patients will die soon. In conclusion, malignancies should be considered in cases of DIC, especially in elderly men in whom no underlying cause can be found to explain it. We recommend doing routine investigations before taking patient for any simple procedures in today’s evidence based practice

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1例早治疗的妊娠期感染性休克并发弥散性血管内凝血的临床分析
Clinical Analysis of a Case of Early Treatment of Infectious Shock in Pregnancy Complicated with Disseminated Intravascular Coagulation [PDF]
杨丽, 周爱芬, 周洁琼
Advances in Clinical Medicine (ACM) , 2023, DOI: 10.12677/ACM.2023.131110

Abstract: 目的：探讨妊娠期感染性休克并发弥散性血管内凝血(Disseminated Intravascular Coagulation, DIC)的早期识别、诊断及治疗。方法：本文将介绍1例我院早期诊断并治疗的妊娠期感染性休克并发DIC的患者。结果：该患者通过及时抗感染、抗休克、去除病灶等对症支持治疗后恢复良好。结论：感染性休克并发DIC为孕产妇死亡的重要原因之一，临床早发现、早诊断、早治疗可降低患者病死率。
Objective: To explore the early identification, diagnosis and treatment of infectious shock compli-cated with disseminated intravascular coagulation in pregnancy. Methods: This article will intro-duce the whole process from onset to treatment of a case of infectious shock complicated with DIC in pregnancy in our hospital. Results: The patient recovered well after timely anti-infection, anti-shock, lesion removal and other symptomatic support treatment. Conclusion: Infectious shock complicated with DIC is one of the important causes of maternal death. Early clinical detection, early diagnosis and early treatment can reduce the mortality of patients.

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肺炎链球菌感染合并爆发性紫癜一例报告
A Case Report of Streptococcus pneumoniae Infection Complicated with Purpura Fulminans [PDF]
曾雯, 蒋亚斌
Advances in Clinical Medicine (ACM) , 2026, DOI: 10.12677/acm.2026.161049

Abstract: 本文报告了一例老年男性患者，因肺炎链球菌(Streptococcus pneumoniae)感染致脓毒血症并发爆发性紫癜(Purpura Fulminans, PF)而死亡的病例。患者因“气促伴全身酸痛1天余，加重3小时”由急诊入院，病程急剧恶化，迅速发展为感染性休克爆发性紫癜(Purpura Fulminans, PF)及多器官功能衰竭。尽管进行了积极的抗生素治疗、重症监护支持和替代治疗，患者仍在入院后48小时内死亡。本病例旨在提高对肺炎链球菌相关暴发性紫癜这一罕见但致命性并发症的认识，强调其起病急骤、病情凶险及早期识别及干预的重要性。
This paper reports a fatal case of an elderly male patient who died of sepsis complicated with purpura fulminans (PF) caused by Streptococcus pneumoniae infection. The patient was admitted to the Emergency Department due to “dyspnea with generalized myalgia for more than 1 day, aggravated for 3 hours”. The disease progressed rapidly, evolving into septic shock, purpura fulminans (PF), and multiple organ failure. Despite aggressive antibiotic therapy, intensive care support, and replacement therapy, the patient died within 48 hours of admission. This case aims to enhance the understanding of this rare but life-threatening complication of Streptococcus pneumoniae-related purpura fulminans, emphasizing its acute onset, critical condition, and the importance of early identification and intervention.

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