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OALib Journal期刊

ISSN: 2333-9721

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Emotion processing in Parkinson’s disease: a blood oxygenation level-dependent functional magnetic resonance imaging study
Amine Bennani,Badreeddine Alami,Driss Boussaoud,Halima El Hamdaoui,Hassane Ali Amadou,Ismail Rammouz,Mohammed Benzagmout,Mounir Jaafari,Mustapha Maaroufi,Rabia Magoul,Sa？d Boujraf
- , 2019, DOI: 10.4103/1673-5374.247470
Abstract: Author contributions: Study design: MB, SB; patient recruitment: MB, HAA, AB; follow-up evaluation: MB, HAA, AB, MJ, IR; fMRI data acquisition: MB, SB, BA, HEH; image post-processing: HEH, BA; result interpretation: SB, BA, DB; psychiatric evaluation: MJ, IR, AB, DB; imaging examination: MM; statistical analysis: SB; paper writing: MB, DB; paper review: SB, IR; PhD supervisor: RM. All authors approved the final version of this paper
Statistical Analysis of fMRI Time-Series: A Critical Review of the GLM Approach
Martin M. Monti
Frontiers in Human Neuroscience , 2011, DOI: 10.3389/fnhum.2011.00028
Abstract: Functional magnetic resonance imaging (fMRI) is one of the most widely used tools to study the neural underpinnings of human cognition. Standard analysis of fMRI data relies on a general linear model (GLM) approach to separate stimulus induced signals from noise. Crucially, this approach relies on a number of assumptions about the data which, for inferences to be valid, must be met. The current paper reviews the GLM approach to analysis of fMRI time-series, focusing in particular on the degree to which such data abides by the assumptions of the GLM framework, and on the methods that have been developed to correct for any violation of those assumptions. Rather than biasing estimates of effect size, the major consequence of non-conformity to the assumptions is to introduce bias into estimates of the variance, thus affecting test statistics, power, and false positive rates. Furthermore, this bias can have pervasive effects on both individual subject and group-level statistics, potentially yielding qualitatively different results across replications, especially after the thresholding procedures commonly used for inference-making.
慢性肾病早期肾间质纤维化磁共振功能成像的初步研究
Functional Evaluation of Early Renal Interstitial Fibrosis in Patients with Chronic Kidney Disease Using Diffusion-Weighted and BOLD MR Imaging: Preliminary Experience  [PDF]
邬颖华, 吴苾, 苏北海, 宋彬
Medical Diagnosis (MD) , 2013, DOI: 10.12677/MD.2013.34012
Abstract:
目的：探讨MR DWI和BOLD应用于临床评价慢性肾病患者早期肾间质纤维化功能改变的价值。方法：收集了26例经肾穿刺活检证实为早期肾间质纤维化的慢性肾脏患者，男12例，女14例，平均年龄38.7岁(16~71岁)；26例健康自愿者为对照组，其年龄、性别与病例组匹配。采用GE 3.0T磁共振仪行T1WI、T2WI、DWI (b = 600 s/mm2)及BOLD扫描成像。利用工作站Fuctool软件对所有DWI和BOLD图像进行后处理，由两名有经验的主治医师对研究对象肾实质兴趣区的ADC值和R2*值进行测量和统计分析。结果：病例组26例早期肾间质纤维化的慢性肾病患者中15.4%(4/26)血清肌酐、尿素升高；84.6%(22/26)尿微量蛋白定量升高；病例组左、右肾实质ADC值较对照组减小(P <
Altered intrinsic brain activities in patients with acute eye pain using amplitude of low-frequency fluctuation: a resting-state fMRI study
Hai-Jun Li,Jing Bao,Lei Ye,Ming-Yang Ma,Nan Jiang,Pei-Wen Zhu,Qing Yuan,Shelby Freeberg,Xin Huang,Yi Shao,Zhi-Ming Pan
- , 2018, DOI: 10.2147/NDT.S150051
Abstract: Many previous studies have reported that pain symptoms can lead to significant brain function and anatomical changes, whereas the intrinsic brain activity changes in acute eye pain (EP) patients remain unknown. Using the amplitude of low-frequency fluctuation (ALFF) method, this study aimed to evaluate the spontaneous brain activity alterations and their relationships with clinical features in acute EP patients
Interpreting oxygenation-based neuroimaging signals: the importance and the challenge of understanding brain oxygen metabolism
Richard B. Buxton
Frontiers in Neuroenergetics , 2010, DOI: 10.3389/fnene.2010.00008
Abstract: Functional magnetic resonance imaging is widely used to map patterns of brain activation based on blood oxygenation level dependent (BOLD) signal changes associated with changes in neural activity. However, because oxygenation changes depend on the relative changes in cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2), a quantitative interpretation of BOLD signals, and also other functional neuroimaging signals related to blood or tissue oxygenation, is fundamentally limited until we better understand brain oxygen metabolism and how it is related to blood flow. However, the positive side of the complexity of oxygenation signals is that when combined with dynamic CBF measurements they potentially provide the best tool currently available for investigating the dynamics of CMRO2. This review focuses on the problem of interpreting oxygenation-based signals, the challenges involved in measuring CMRO2 in general, and what is needed to put oxygenation-based estimates of CMRO2 on a firm foundation. The importance of developing a solid theoretical framework is emphasized, both as an essential tool for analyzing oxygenation-based multimodal measurements, and also potentially as a way to better understand the physiological phenomena themselves. The existing data, integrated within a simple theoretical framework of O2 transport, suggests the hypothesis that an important functional role of the mismatch of CBF and CMRO2 changes with neural activation is to prevent a fall of tissue pO2. Future directions for better understanding brain oxygen metabolism are discussed.
Blood oxygen level
Dong Li,Huilan Shi,Junya Jia,Li Wei,Wenya Shang,Zhenfeng Zheng
- , 2018, DOI: 10.1177/0300060517721794
Abstract: Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) is a noninvasive technique useful in patients with renal disease. The current study was performed to determine whether BOLD MRI can contribute to the diagnosis of renal pathological patterns. BOLD MRI was used to obtain functional magnetic resonance parameter R2* values. Gray-level co-occurrence matrixes (GLCMs) were generated for gray-scale maps. Several GLCM parameters were calculated and used to construct algorithmic models for renal pathological patterns. Histopathology and BOLD MRI were used to examine 12 patients. Two GLCM parameters, including correlation and energy, revealed differences among four groups of renal pathological patterns. Four Fisher’s linear discriminant formulas were constructed using two variables, including the correlation at 45° and correlation at 90°. A cross-validation test showed that the formulas correctly predicted 28 of 36 samples, and the rate of correct prediction was 77.8%. Differences in the texture characteristics of BOLD MRI in patients with lupus nephritis may be detected by GLCM analysis. Discriminant formulas constructed using GLCM parameters may facilitate prediction of renal pathological patterns
脑震荡急性期患者功能磁共振低频振幅变化意义初探
The Changes of Amplitude of Low-Frequency Fluctuation in the Acute Phase Patients with Concussion  [PDF]
王卫民, 郝泽林, 程军, 吴建跃, 裘五四, 姜启周, 肖国民, 臧玉峰, 丁建平
Asian Case Reports in Emergency Medicine (ACREM) , 2015, DOI: 10.12677/ACREM.2015.32002
Abstract:
目的：探讨伴有认知功能改变的脑震荡急性期患者功能磁共振低频振幅(ALFF)变化与其临床症状之间的关系。方法：采用静息态血氧水平依赖功能磁共振成像(BOLD-fMRI)及其低频振幅(ALFF)计算法，对急性期伴有认知功能改变的脑震荡患者在静息状态下获得相关资料进行分析。研究组为脑震荡成年患者10人；对照组为健康成年志愿者10人。研究组10人均在伤后72小时内完成BOLD-fMRI检查。两组均采用GE公司制造MR750 3.0T磁共振成像系统，在静息态下采集BOLD-fMRI成像数据。结果：与对照组比较，研究组在边缘叶、扣带回、楔前叶、左侧颞上回、颞中回、右侧额上回等脑区表现为ALFF值升高，临床上出现记忆能力、语言表达、情绪反应等认知功能改变。结论：脑震荡急性期患者认知功能异常，可能与边缘叶、扣带回、右侧前额叶等脑区ALFF值升高相关。
Objective: To investigate the change of amplitude of low-frequency fluctuation (ALFF) in acute phase patients with concussion. Methods: 10 patients with concussion and 10 healthy control subjects were performed at GE MR750 3T by using the methods of blood oxygenation level de-pendent-functional magnetic resonance imaging (BOLD fMRI) and ALFF in this study. Results: Compared with the control subjects, the patients with concussion showed significantly increased ALFF values in limbic lobe, cingulate gyrus, precuneus, left superior temporal gyrus, left middle temporal gyrus and right frontal gyrus. The clinical manifestations of these patients were the changes of cognitive function such as memory, language and emotional responses. Conclusion: The changes of cognitive function on the patients with concussion were associated with the increased ALFF values in the cognitive-related brain areas.
Network-specific resting-state connectivity changes in the premotor-parietal axis in writer's cramp
Angela Jochim,Bernhard Haslinger,Christian Dresel,Gina Gora-Stahlberg,Jona Kr？enbring,Maria Berndt,Tobias Mantel,Tobias Meindl,Yong Li
- , 2018, DOI: 10.1016/j.nicl.2017.10.001
Abstract: Writer's cramp is a task-specific dystonia impairing writing and sometimes other fine motor tasks. Neuroimaging studies using manifold designs have shown varying results regarding the nature of changes in the disease
Fractional Amplitude of Low-Frequency Fluctuations and Functional Connectivity in Comatose Patients Subjected to Resting-State Functional Magnetic Resonance Imaging
Ling Zhang,Lixuan Huang,Muyan Li,Yan Zheng,Yang Gao,Zisan Zeng
- , 2019, DOI: 10.4103/aian.AIAN_420_17
Abstract:
Acquisition of sensorimotor fMRI under general anaesthesia: Assessment of feasibility, the BOLD response and clinical utility
Adam Kenji Yamamoto,Andrew W. McEvoy,Anna Miserocchi,Caroline Micallef,Cathy J. Price,Ian Appleby,Joerg Magerkurth,John S. Thornton,Laura Mancini,Mark J. White,Nikolaus Weiskopf,Tarek A. Yousry
- , 2019, DOI: 10.1016/j.nicl.2019.101923
Abstract:
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