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OALib Journal期刊

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Toxicity and Antimicrobial Activities of Ionic Liquids with Halogen Anion  [PDF]
You Yu, Yi Nie
Journal of Environmental Protection (JEP) , 2011, DOI: 10.4236/jep.2011.23033
Abstract: To investigate the eco-toxicity of ionic liquids (ILs), experiments on growth of three kinds of bacteria were carried out for six common ILs with halogen anion by a micro-calorimetric method at 310 k. The results indicate that the growth of all the bacteria was inhibited in the presence of ILs. In addition, all ILs at definite concentrations show some toxicity to Escherichia coli, Staphylococcus aureus and Bacillus subtilis. Anti-microbial activities of the ILs with halogen anion are strongly related to structures of the ILs. An increase in alkyl group chain length corresponds with an increase in toxicity, and the ILs with pyridinium cation exhibit stronger restraining effect than the same series ILs with imidazolium cation.
Indolin-2-Ones in Clinical Trials as Potential Kinase Inhibitors: A Review  [PDF]
Chinnasamy Rajaram Prakash, Sundararajan Raja, Panneerselvam Theivendren
Pharmacology & Pharmacy (PP) , 2012, DOI: 10.4236/pp.2012.31010
Abstract: The kinases have been intensely studied because of their involvement in regulating essential cellular activation of signaling cascades in response to extracellular and intracellular stimuli to control cell growth, proliferation, and survival. Recent cancer genomic sequencing studies have revealed that many more kinases contribute to tumor genesis and are potential targets for inhibitor drug development intervention. Herein we review recent results that have helped to unravel the indolin-2-ones underlying the confiicting roles of the kinase inhibition regulation. This review focuses on the potential of kinases as a chemotherapeutic target in cancer treatment and highlights important recent advances in the development of indolin-2-ones as kinase inhibitors.
Social Inhibition of Vection  [PDF]
Takeharu Seno
Psychology (PSYCH) , 2013, DOI: 10.4236/psych.2013.48088
Abstract:

The purpose of this study was to examine whether the social interaction can affect vection strength. We compared the strength of self-motion perception (vection) with and without an audience (two people in addition to the participant) present during stimulus presentation. We presented the optical flow (dots’ expansion) for 40 seconds and obtained vection duration and latency and we also obtained the subjective strength of vection via magnitude estimation. We found that vection was inhibited by the presence of an audience. We speculate that audience presence might distract the attention of participants from the vection, depriving them of the attentional resources inhibited vection.

Experimental Study on a New Corrosion and Scale Inhibitor  [PDF]
Defang Zeng, Huan Yan
Journal of Environmental Protection (JEP) , 2013, DOI: 10.4236/jep.2013.47077
Abstract:

The mixture consisted of benzotriazole (BTA), chitosan (CTS), polyacrylic acid and zinc salt has been investigated as a corrosion and scale inhibitor of A3 carbon steel in cooling water. The scale and corrosion inhibition efficiency was evaluated by static anti-scaling teat together with rotary coupon test. Compared with the phosphorus corrosion and scale inhibitor, the corrosion inhibition rate and scale inhibition rate of it increased respectively by 2.51% and 1.16%. As the corrosion and scale inhibitor is phosphate-free, it won’t cause eutrophication, considering the product performance and environmental influence, the phosphate-free corrosion and scale inhibitor is superior to the traditional one.

Fusarium lini Potential for the Biotransformation of Norandrostenedione and Evaluation of Urease and Chymotrypsin Properties of the Transformed Products  [PDF]
Simeon Pierre Chegaing Fodouop, Alex Doris Kengni Mboussaah, Didiane Yemele Mefokou, Alain Bertrand Fowa, Mahwish Siddiqui, Gabriel T. Kamsu, Donatien Gatsing, Muhammad Iqbal Choudhary
Advances in Biological Chemistry (ABC) , 2021, DOI: 10.4236/abc.2021.112006
Abstract: Several androgenic steroids have been biotransformed by fungi into metabolites with numerous biological properties. Incubation of norandrostenedione (1) with Fusarium lini NRRL 2204 was carried out for the first time, yielding two new metabolites, 3,7β-dihydroxy-19-norandrost-1,3,5-trien-17-one (3) and 6α,10β,17β-trihydroxy-19-nor-4-androsten-3-one (4), along with three known compounds, 3-hydroxy-19-norandrost-1,3,5-trien-17-one (2), 10β, 17β-dihydroxy-19-nor-4-androsten-3-one (5) and 10β-hydroxy-19-nor-4-
Exploring the Biodiversity of Rare Actinobacteria for Combating AMR: Screening for Anti-Quorum Sensing Properties  [PDF]
Sunita Bundale, Nisha Nikam, Ketki Gwalani, Jaya Singh, Aaliya Farooqui, Nandita Nashikkar
Advances in Microbiology (AiM) , 2025, DOI: 10.4236/aim.2025.156024
Abstract: The rise of antimicrobial resistance (AMR) poses a significant global health challenge, necessitating the search for alternative therapeutic strategies. Targeting bacterial quorum sensing (QS), a communication system that regulates virulence and biofilm formation, has emerged as a promising anti-virulence approach. Actinobacteria, renowned for their prolific production of bioactive secondary metabolites, represent a valuable resource for discovering novel anti-quorum-sensing (AQS) compounds. This study explores the biodiversity of actinobacteria from diverse ecological niches to identify strains with anti-QS properties. Using Chromobacterium violaceum and Serratia marcescens as biosensors, actinobacterial extracts were screened for their ability to inhibit QS-regulated pigment production. Selected extracts were further evaluated for swarming motility inhibition and potent strains were identified. Four rare actinobacterial strains MG1, BD21, MG3 and VL9 identified as Kutzneria viridogrisea, Microbacterium barkeri, Amycolatopsis thermoflava and Yuhushiella sp. were studied for their biofilm inhibition activity and prodigiosin inhibition in pathogenic bacteria. Our findings are the first to highlight the potential of these rare actinobacteria as a source of novel anti-QS agents, contributing to the development of alternative strategies to mitigate AMR.
Effects of AGE Inhibition with Aminoguanidine in a Diabetic db/db Mouse Wound Model  [PDF]
Margrete Berdal, Trond Jenssen
Journal of Diabetes Mellitus (JDM) , 2014, DOI: 10.4236/jdm.2014.42017
Abstract:

Advanced glycation end products (AGEs) react non-enzymatically with tissue proteins to form irreversible structures involved in atherosclerosis, nephropathy, retinopathy, neuropathy, and wound healing. Studies on AGE-inhibitors have demonstrated possible prevention of diabetes complications. The present open label study was conducted on aminoguanidine (AGu), an inhibitor of AGE-formation, to examine potential effects on wound healing in diabetes type 2-like db/db mice during 5 - 6 weeks. The animals were divided into 4 groups: AGu from the day of wounding (day 0) topically and/or systemically in drinking water (1 g/L; group 1, n = 13); AGu 1 g/L in drinking water from 7 weeks prior to day 0 (group 2, n = 21); AGu 5 g/L in drinking water from 9 - 11 weeks prior to day 0 (group 3, n = 6); placebo controls (group 4, n = 8). Results: Glycated hemoglobin (A1C) was significantly lower in group 3 compared to the other groups (P < 0.05). Percentage change in A1C and body weight from baseline to the end of the experiment were both related to the AGu doses (1 or 5 g/L; A1C-change, P

Associative learning in ADHD: improved expression under methylphenidate  [PDF]
Ebrahim Kantini, Helen Joan Cassaday, Martin Joseph Batty, Chris Hollis, Georgina Margaret Jackson
Open Journal of Psychiatry (OJPsych) , 2011, DOI: 10.4236/ojpsych.2011.12004
Abstract: Attention Deficit/Hyperactivity Disorder (ADHD) is characterised by developmentally inappropriate levels of inattention, impulsivity and hyperactivity. As might be expected of a disorder in which inhibitory deficits form part of the diagnostic criteria, deficits in response inhibition in ADHD have been evidenced in a number of studies. To date, the tasks used in such studies have required participants to inhibit the learned stimulus-response associations that result in unwanted behavior. However, no research has examined the inhibition of stimulus-stimulus associations, formally ‘conditioned inhibition’. The present study used video game style conditioned inhibition procedures, developed for children and adolescents with a clinical diagnosis of ADHD and suitable for typically developing matched controls. Two computer-based tasks (‘Mission to Mars’ and ‘Weapon-X’) required participants to predict the occurrence of an outcome based on the stimuli presented. We selected 12 male participants with ADHD on medication (methylphenidate), but without comorbid Tourette Syndrome, pervasive developmental disorder, learning disability or psychosis. This group showed overall normal inhibition of stimulus-stimulus associations, measured repeatedly over trials and with two task variants. There was no correlation between inhibitory learning and symptom severity ratings. However, participants with ADHD on higher dosages of methylphenidate, or longer duration of treatment with methylphenidate, showed improved ability to anticipate outcomes following the different stimulus presentations on non-inhibited versus inhibited trials. This effect was most clearly demonstrated on the Weapon-X task. Thus, methylphenidate doserelatedly improved the expression of associative learning. This action may contribute to its therapeutic effects in improving cognitive function in ADHD.
The central nucleus of amygdala is involved in tolerance to the antinociceptive effect of NSAIDs  [PDF]
Merab G. Tsagareli, Nana Tsiklauri, Gulnazi Gurtskaia, Ivliane Nozadze, Elene Abzianidze
Health (Health) , 2010, DOI: 10.4236/health.2010.21010
Abstract: Aim: Repeated microinjections of non-opioid an-algesics into the midbrain periaqueductal gray matter and rostral ventro-medial medulla induce antinociception with development of tolerance. Antinociception following systemic administra-tion of non-steroidal anti-inflammatory drugs (N SAIDs) also exhibit tolerance. Presently our aim was to investigate the development of tolerance to the antinociceptive effects of NSAIDs analgine, ketorolac, and xefocam microinjected into cen-tral nucleus of amygdala (Ce) in rats. Methods: Under anesthesia with thiopental a stainless steel guide cannula was stereotaxically implanted uni- laterally or bilaterally into the Ce using stereo-taxic atlas coordinates, and anchored to the cra- nium by dental cement. Five days after surgery, 3 µl of these NSAIDs were injected via the injec-tion cannula while the rat was gently restrained. Twenty min post microinjection, i.e. 10-min be-fore the peak of the drugs’ effect is normally rea- ched, animals were tested with tail flick (TF) and hot plate (HP) tests. On the 5th experimental day all animals received a Ce microinjection of mor-phine. Results: Daily microinjection of NSAIDs into the Ce uni- or bilaterally, produced antino-ciception with development of complete toler-ance over a 5-day period. Following the treat-ment period, morphine microinjection into the Ce failed to elicit antinociception, indicating cro- ss-tolerance to the antinociceptive effect of N SAIDs. In other words, the “non-opioid tolerant” rats showed cross-tolerance to morphine. Con-clusions: Our data confirmed the suggestion that NSAIDs interact with endogenous opioid systems, which likely play a key role in the development of tolerance to the antinociceptive effects of NSA IDs.
Response Inhibition and Memory Retrieval of Emotional Target Words: Evidence from an Emotional Stop-Signal Task  [PDF]
Cornelia Herbert, Stefan Sütterlin
Journal of Behavioral and Brain Science (JBBS) , 2011, DOI: 10.4236/jbbs.2011.13020
Abstract: Previous research suggests that emotional stimuli capture attention and guide behavior often automatically. The present study investigated the relationship between emotion-driven attention capture and motor response inhibition to emotional words in the stop-signal task. By experimental variations of the onset of motor response inhibition across the time-course of emotional word processing, we show that processing of emotional information significantly interferes with motor response inhibition in an early time-window, previously related to automatic emotion-driven attention capture. Second, we found that stopping reduced memory recall for unpleasant words during a subsequent surprise free recall task supporting assumptions of a link between mechanisms of motor response inhibition and memory functions. Together, our results provide behavioral evidence for dual competition models of emotion and cognition. This study provides an important link between research focusing on different sub-processes of emotion processing (from perception to action and from action to memory).
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