全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

Development and Validation of a Vascular Flow Phantom for Doppler Ultrasound Evaluation

DOI: 10.4236/jbise.2026.196016, PP. 189-209

Keywords: Phantom, Tissue-Mimicking Material, Doppler Ultrasound, Vascular Flow

Full-Text   Cite this paper   Add to My Lib

Abstract:

Vascular flow phantoms are essential tools for the calibration of Doppler ultrasound systems, professional training, and experimental hemodynamic studies. This study aimed to develop and validate a low-cost vascular flow phantom capable of reproducing clinically relevant blood flow patterns, including disturbed and non-laminar conditions, for Doppler ultrasound evaluation. The proposed system consists of tissue-mimicking materials, vessel-mimicking structures, a controlled hydraulic circuit, and an embedded electronic control system based on the ESP32 microcontroller. Metallic spheres were incorporated within the flow channel to generate controlled flow perturbations, enabling the simulation of complex hemodynamic scenarios. Experimental validation was performed using a ultrasound system with standardized acquisition parameters. The phantom successfully reproduced distinct flow regimes, including laminar and turbulent conditions. Quantitative Doppler measurements demonstrated clear differences between flow profiles, including spectral broadening and heterogeneous color flow patterns in regions with induced disturbances, supporting the reproducibility and functional reliability of the proposed system. The results indicate that the developed phantom is suitable for biomedical engineering research, ultrasound training, and functional validation of Doppler imaging systems. Its modular structure also enables future expansion for more complex cardiovascular simulations.

References

[1]  Fu?ík, R., Galabov, R., Pau?, P., Eichler, P., Klinkovsky, J., Straka, R., et al. (2020) Investigation of Phase-Contrast Magnetic Resonance Imaging Underestimation of Turbulent Flow through the Aortic Valve Phantom: Experimental and Computational Study Using Lattice Boltzmann Method. Magnetic Resonance Materials in Physics, Biology and Medicine, 33, 649-662.
https://doi.org/10.1007/s10334-020-00837-5
[2]  Adusei, S., Ternifi, R., Fatemi, M. and Alizad, A. (2023) Custom-Made Flow Phantoms for Quantitative Ultrasound Microvessel Imaging. Ultrasonics, 134, Article ID: 107092.
https://doi.org/10.1016/j.ultras.2023.107092
[3]  Hoferer, I., Jourdain, L., Girot, C., Benatsou, B., Leguerney, I., Cournede, P., et al. (2023) New Calibration Setup for Quantitative DCE-US Imaging Protocol: Toward Standardization. Medical Physics, 50, 5541-5552.
https://doi.org/10.1002/mp.16362
[4]  Dakok, K.K., Matjafri, M.Z., Suardi, N., Oglat, A.A. and Nabasu, S.E. (2021) A Review of Carotid Artery Phantoms for Doppler Ultrasound Applications. Journal of Medical Ultrasound, 29, 157-166.
https://doi.org/10.4103/jmu.jmu_164_20
[5]  Capellini, K., Ait-Ali, L., Pak, V., Cantinotti, M., Murzi, M., Vignali, E., et al. (2024) Three-Dimensional Printed Models as an Effective Tool for the Management of Complex Congenital Heart Disease. Frontiers in Bioengineering and Biotechnology, 12.
https://doi.org/10.3389/fbioe.2024.1369514
[6]  Cheng, A., Guo, X., Zhang, H.K., Kang, H.J., Etienne-Cummings, R. and Boctor, E.M. (2017) Active Phantoms: A Paradigm for Ultrasound Calibration Using Phantom Feedback. Journal of Medical Imaging, 4, Article ID: 035001.
https://doi.org/10.1117/1.jmi.4.3.035001
[7]  Shen, C., Lyu, L., Wang, G. and Wu, J. (2019) A Method for Ultrasound Probe Calibration Based on Arbitrary Wire Phantom. Cogent Engineering, 6, Article ID: 1592739.
https://doi.org/10.1080/23311916.2019.1592739
[8]  Madsen, E.L., Hobson, M.A., Shi, H., Varghese, T. and Frank, G.R. (2005) Tissue-Mimicking Agar/Gelatin Materials for Use in Heterogeneous Elastography Phantoms. Physics in Medicine and Biology, 50, 5597-5618.
https://doi.org/10.1088/0031-9155/50/23/013
[9]  Pavan, T.Z., Madsen, E.L., Frank, G.R., Jiang, J., Carneiro, A.A.O. and Hall, T.J. (2012) A Nonlinear Elasticity Phantom Containing Spherical Inclusions. Physics in Medicine and Biology, 57, 4787-4804.
https://doi.org/10.1088/0031-9155/57/15/4787
[10]  Bontempi, L., Zattoni, M., Ramella, A., Migliavacca, F., Ringgaard, S., Kim, W.Y., et al. (2025) Idealized Aortic Annuloplasty FSI Digital Twin of 3d-Printed Phantoms with 4d-Flow MRI Comparison. Computers in Biology and Medicine, 192, 110398.
https://doi.org/10.1016/j.compbiomed.2025.110398
[11]  Iniewski, K. (2012) Biological and Medical Sensor Technologies. CRC Press.
[12]  Hobbie, R. and Roth, B.J. (2007) Intermediate Physics for Medicine and Biology. Springer.
[13]  Carovac, A., Smajlovic, F. and Junuzovic, D. (2011) Application of Ultrasound in Medicine. Acta Informatica Medica, 19, 168-171.
https://doi.org/10.5455/aim.2011.19.168-171
[14]  Schmid-Wendtner, M. and Dill-Müller, D. (2008) Ultrasound Technology in Dermatology. Seminars in Cutaneous Medicine and Surgery, 27, 44-51.
https://doi.org/10.1016/j.sder.2008.01.003
[15]  Elmer, K.M., Caffin, C., Scott, B., Stephens, S.E. and Jensen, M.O. (2025) Development and Characteristics of a Dual-Layered Vascular Phantom. Cardiovascular Engineering and Technology, 17, 25-40.
https://doi.org/10.1007/s13239-025-00810-0
[16]  Abu-Zidan, F., Hefny, A. and Corr, P. (2011) Clinical Ultrasound Physics. Journal of Emergencies, Trauma, and Shock, 4, 501-503.
https://doi.org/10.4103/0974-2700.86646
[17]  Christensen, D. (1988) Ultrasonic Bioinstrumentation. Wiley.
[18]  Papaléo, R.M. and De Souza, D.S. (2019) Ultrassonografia: Princípios Físicos e Controle da Qualidade. Revista Brasileira de Física Médica, 13, 14-23.
https://doi.org/10.29384/rbfm.2019.v13.n1.p14-23
[19]  Vieira, S.L., Pavan, T.Z., Junior, J.E. and Carneiro, A.A.O. (2013) Paraffin-Gel Tissue-Mimicking Material for Ultrasound-Guided Needle Biopsy Phantom. Ultrasound in Medicine & Biology, 39, 2477-2484.
https://doi.org/10.1016/j.ultrasmedbio.2013.06.008
[20]  Movahed, M. (2007) Interference of Breast Implants with Echocardiographic Image Acquisition and Interpretation. Cardiovascular Ultrasound, 5, Article No. 9.
https://doi.org/10.1186/1476-7120-5-9
[21]  Honer, J.S. and McGough, R.J. (2025) Fast and Accurate Plane Wave and Color Doppler Imaging with the FOCUS Software Package. Sensors, 25, 4276.
https://doi.org/10.3390/s25144276
[22]  Lai, P., Xu, X. and Wang, L.V. (2014) Dependence of Optical Scattering from Intralipid in Gelatin-Gel Based Tissue-Mimicking Phantoms on Mixing Temperature and Time. Journal of Biomedical Optics, 19, 035002.
https://doi.org/10.1117/1.jbo.19.3.035002
[23]  Kim, N., Hong, C., Lee, C. and Cho, H. (2023) Development and Evaluation of Doppler Ultrasound Training Phantom for Human Vessel Simulation. Applied Sciences, 13, 9932.
https://doi.org/10.3390/app13179932
[24]  Oliveira, J.R.D., Aquino, M.D.A., Barros, S., Pitta, G.B.B. and Pereira, A.H. (2016) Alterations of Blood Flow Pattern after Triple Stent Endovascular Treatment of Saccular Abdominal Aortic Aneurysm: A Porcine Model. Revista do Colégio Brasileiro de Cirurgi?es, 43, 154-159.
https://doi.org/10.1590/0100-69912016003004
[25]  Pinto, L.T.M., Januário, J.R., Nogueira, C.S., et al. (2021) Análise CFD do escoamento no interior da bifurca??o da carótida. Revista Interdisciplinar de Pesquisa em Engenharia, 2, 143-158.
[26]  Ishii, T., Takabe, S., Yanagawa, Y., Ohshima, Y., Kagawa, Y., Shibata, A., et al. (2019) Laser Doppler Blood Flowmeter as a Useful Instrument for the Early Detection of Lower Extremity Peripheral Arterial Disease in Hemodialysis Patients: An Observational Study. BMC Nephrology, 20, 470.
https://doi.org/10.1186/s12882-019-1653-y
[27]  Araújo, A.F., et al. (2021) Síndrome do roubo de subclávia. FHEMIG.
[28]  Sherwood, L. (2011) Fundamentals of Physiology. Thomson.
[29]  (2019) ISO 14971:2019, Medical Devices—Risk Management. ISO.
[30]  Calas, M.J.G., Koch, H.A. and Dutra, M.V.P. (2007) Ultra-sonografia mamária: Avalia??o dos critérios ecográficos na diferencia??o das les?es mamárias. Radiologia Brasileira, 40, 1-7.
https://doi.org/10.1590/s0100-39842007000100003
[31]  Laughlin, M.E., Stephens, S.E., Hestekin, J.A. and Jensen, M.O. (2021) Development of Custom Wall-Less Cardiovascular Flow Phantoms with Tissue-Mimicking Gel. Cardiovascular Engineering and Technology, 13, 1-13.
https://doi.org/10.1007/s13239-021-00546-7
[32]  Dias, J.C., Souza, M.V.A.D., Dias, J.C., Silva, L.C.D. and Filho, D.J.D.S. (2025) Development and Implementation of a Project Using Iomt Technology for Monitoring, Remote Control, and Tracking of a Left Ventricular Assist Device: Reduction of Adverse Events Caused by Malfunction Leading to Critical and Catastrophic Failures. Journal of Biomedical Science and Engineering, 18, 250-261.
https://doi.org/10.4236/jbise.2025.186018
[33]  Reiss, N., Schmidt, T., Boeckelmann, M., Schulte-Eistrup, S., Hoffmann, J., Feldmann, C., et al. (2018) Telemonitoring of Left-Ventricular Assist Device Patients—current Status and Future Challenges. Journal of Thoracic Disease, 10, S1794-S1801.
https://doi.org/10.21037/jtd.2018.01.158
[34]  Saeed, D., Feldman, D., Banayosy, A.E., et al. (2023) The 2023 International Society for Heart and Lung Transplantation Guidelines for Mechanical Circulatory Support: A 10-Year Update. The Journal of Heart and Lung Transplantation, 42, e1-e222.
[35]  Phuttharak, J. and Loke, S.W. (2023) An Event-Driven Architectural Model for Integrating Heterogeneous Data and Developing Smart City Applications. Journal of Sensor and Actuator Networks, 12, 12.
https://doi.org/10.3390/jsan12010012
[36]  Rapp, E.S., Pawar, S.R. and Longoria, R.G. (2022) Hybrid Mock Circulatory Loop Simulation of Extreme Cardiac Events. IEEE Transactions on Biomedical Engineering, 69, 2883-2892.
https://doi.org/10.1109/tbme.2022.3156963

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133