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Pharmacy Information 2026
O-GlcNAc糖基化在糖尿病及其并发症中的研究进展
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Abstract:
O-连接β-N-乙酰葡糖胺(O-Linked β-N-Acetylglucosamine, O-GlcNAc)糖基化是一种动态可逆的蛋白质翻译后修饰，可发生于细胞内数千种蛋白的丝氨酸或苏氨酸残基上，通过调控转录、表观遗传和信号传导在各种细胞过程中起重要作用。糖尿病是一种慢性代谢疾病，长期高血糖可累及多种组织器官，导致一系列并发症。近年来，越来越多的证据表明，O-GlcNAc糖基化修饰广泛参与糖尿病及其并发症的发生与发展。文章梳理了O-GlcNAc糖基化修饰调控机制和生理作用，重点探讨了O-GlcNAc糖基化修饰在糖尿病及其并发症中的作用机制。
O-linked β-N-acetylglucosamine (O-GlcNAc) glycosylation is a dynamically reversible protein post-translational modification that is present on serine or threonine residues of thousands of proteins in cells and plays an important role in various cellular processes by regulating transcription, epigenetics, and signaling. Diabetes is a chronic metabolic disease, and long-term hyperglycemia can affect a variety of tissues and organs, leading to a series of complications. In recent years, accumulating evidence has indicated that O-GlcNAc glycosylation is extensively involved in the occurrence and development of diabetes and its complications. This article reviews the regulatory mechanisms and physiological functions of O-GlcNAc glycosylation, with a focus on its mechanistic roles in diabetes and its complications.
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