Angiofibromas are highly vascularized benign lesions that mainly arise in adolescent male patients in the region of the nasopharynx. Extra nasopharyngeal angiofibromas are rare entities. We present a case of an unusual site of angiofibromas. It is a 39-year-old patient, male referred to our hospital for a right cervical and oropharyngeal swelling that has been evolving for 7 years and increased rapidly in size 4 months ago. A computed tomographic (CT) scan with contrast agent injection revealed the presence of a mass obliterating the right parapharyngeal space without specific aspect. After complete removal, an angiofibroma was found in the histological analysis. Angiofibromas should be added to the differential diagnosis of the parapharyngeal tumors as they require specific management, especially avoiding invasive biopsies.
References
[1]
Panda, N.K., Patro, S.K., Behera, S., Agarwal, P. and Das, A. (2021) Parapharyngeal Space Angiofibroma: A Diagnostic Surprise. Iranian Journal of Otorhinolaryngology, 33, 107-111.
[2]
Eisele, D.W. and Richmon, J.D. (2013) Contemporary Evaluation and Management of Parapharyngeal Space Neoplasms. TheJournalofLaryngology&Otology, 127, 550-555. https://doi.org/10.1017/s0022215113000686
[3]
Matsuki, T., Tsutsumi, S., Miyamoto, S., Kano, K., Momiyama, K., Asako, Y., et al. (2021) Removal of a Giant Parapharyngeal Space Oncocytoma without Osteotomy. Ear, Nose&ThroatJournal, 103, NP203-NP206. https://doi.org/10.1177/01455613211048973
Hoon Lee, B. (2015) Parapharyngeal Angiofibroma: A Case Report. IranianJournalofRadiology, 12, e17353. https://doi.org/10.5812/iranjradiol.12(3)2015.17353
[6]
Windfuhr, J.P. and Vent, J. (2017) Extranasopharyngeal Angiofibroma Revisited. Clinical Otolaryngology, 43, 199-222. https://doi.org/10.1111/coa.12939
[7]
Basu, N., Mondal, P., Gupta, S., Bhattacharya, N. and Mallick, M. (2009) Fine Needle Aspiration Cytology of Parapharyngeal Tumors. JournalofCytology, 26, 102-104. https://doi.org/10.4103/0970-9371.59395
[8]
Bulut, O.C., Giger, R., Alwagdani, A., Aldabal, N., Stenzinger, A., Heimgartner, S., et al. (2021) Primary Neoplasms of the Parapharyngeal Space: Diagnostic and Therapeutic Pearls and Pitfalls. EuropeanArchivesofOto-Rhino-Laryngology, 278, 4933-4941. https://doi.org/10.1007/s00405-021-06718-4
[9]
Rao, M.J., Gowda, R.S.N., Umapathy, B. and Navaneeth, B. (2013) Tuberculosis of the Parapharyngeal Space: A Rare Case Report. IndianJournalofPathologyandMicrobiology, 56, 480-481. https://doi.org/10.4103/0377-4929.125400
[10]
Szymańska, A., Szymański, M., Morshed, K., Czekajska-Chehab, E. and Szczerbo-Trojanowska, M. (2013) Extranasopharyngeal angiofibroma: clinical and radiological presentation. EuropeanArchivesofOto-Rhino-Laryngology, 270, 655-660. https://doi.org/10.1007/s00405-012-2041-4
[11]
Gazmenga, F.P., Windfuhr, J.P., Lau, F., Toro, M.D.C. and Sakano, E. (2026) Extranasopharyngeal Angiofibroma of the Sinonasal Tract: A Systematic Review. EuropeanArchivesofOto-Rhino-Laryngology. https://doi.org/10.1007/s00405-025-09985-7
[12]
Windfuhr, J.P. and Remmert, S. (2004) Extranasopharyngeal Angiofibroma: Etiology, Incidence and Management. ActaOto-Laryngologica, 124, 880-889. https://doi.org/10.1080/00016480310015948
