Introduction: Human immunodeficiency virus (HIV) infection remains a public health problem despite the advent of antiretroviral therapy (ART). Prolonged use of ART has been associated with various metabolic toxicities. This study aims to evaluate biological parameters in patients living with HIV who are receiving treatment at the Ambulatory Treatment Center (CTA). Methodology: This was a retrospective, descriptive, and analytical study conducted between January 2021 and December 2024, a period of three years. The study included all patients living with HIV who were followed at the CTA of the Fann University Hospital Center and had undergone biological testing. Results: During the study period, 163 patients were included, with a mean age of 38 years ± 11.94. We noted a male predominance (92 men and 71 women, for a male-to-female ratio of 1.3). From a virological standpoint, HIV-1 was the most frequent, accounting for 93.3% of cases. TLD remained the predominant treatment regimen at the time of the study, used in 91.4% of cases, followed by TAF + FTC + DTG (5.6%). At month 36, 70% of patients had normal hemoglobin levels, and anemia had decreased to 27.1%. Renal function remained generally preserved, with an eGFR > 90 mL/min/1.73m2 in 65.3% of patients. Transaminase levels improved significantly, with a decrease in elevated AST and ALT. Viral load, mostly detectable at baseline (M0), became undetectable in more than 90.9% of patients by month 12 and remained so until month 36. Conclusion: The results confirm the efficacy and tolerability of antiretroviral therapy. Regular laboratory monitoring allows for the early detection of potential metabolic complications.
References
[1]
UNAIDS (2024) Global HIV & AIDS Statistics—Fact Sheet. https://www.unaids.org/en/resources/fact-sheet
[2]
CNLS (2023) Rapport Annuel des Activites de Lutte Conter le VIH. https://www.cnls.cm/uploads/docs/2025-01-02-rapport-annuel-2023-vih-draft-final-latest.pdf
[3]
Nixon, C.C., Vatakis, D.N., Reichelderfer, S.N., Dixit, D., Kim, S.G., Uittenbogaart, C.H., et al. (2013) HIV-1 Infection of Hematopoietic Progenitor Cells in Vivo in Humanized Mice. Blood, 122, 2195-2204. https://doi.org/10.1182/blood-2013-04-496950
[4]
Mu, W., Patankar, V., Kitchen, S. and Zhen, A. (2024) Examining Chronic Inflammation, Immune Metabolism, and T Cell Dysfunction in HIV Infection. Viruses, 16, Article 219. https://doi.org/10.3390/v16020219
[5]
Chawla, A., Wang, C., Patton, C., Murray, M., Punekar, Y., de Ruiter, A., et al. (2018) A Review of Long-Term Toxicity of Antiretroviral Treatment Regimens and Implications for an Aging Population. Infectious Diseases and Therapy, 7, 183-195. https://doi.org/10.1007/s40121-018-0201-6
[6]
Tamir, Z., Alemu, J. and Tsegaye, A. (2018) Anemia among HIV Infected Individuals Taking Art with and without Zidovudine at Addis Ababa, Ethiopia. Ethiopian Journal of Health Sciences, 28, 73-82. https://doi.org/10.4314/ejhs.v28i1.9
[7]
Greder Belan, A., Chaplain, C. and Boussairi, A. (2008) Suivi biologique de l’infection à VIH chez l’adulte. Immuno-Analyse& BiologieSpécialisée, 23, 95-102. https://doi.org/10.1016/j.immbio.2008.03.002
[8]
Panel on Antiretroviral Guidelines for Adults and Adolescents (2001) Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV. Department of Health and Human Services. https://clinicalinfo.hiv.gov/sites/default/files/guidelines/documents/adult-adolescent-arv/guidelines-adult-adolescent-arv.pdf
[9]
Adébayo, A., Comlan, D.A., Ericie, S., Angelo, A., Jules, G., Armand, W., et al. (2015) Prévalence, facteurs associés et prédisposant du syndrome métabolique chez les personnes vivants avec le VIH sous traitement antirétroviral à Porto-Novo en 2014. Pan African Medical Journal, 22, Article 296. https://doi.org/10.11604/pamj.2015.22.296.7923
[10]
Karfo, R., Kabré, E., Coulibaly, L., Diatto, G., Sakandé, J. and Sangaré, L. (2018) Evolution des paramètres biochimiques et hématologiques chez les personnes vivant avec le VIH SIDA sous traitement antirétroviral au Centre Médical du Camp General Aboubacar Sangoule Lamizana (CMCGASL). Pan African Medical Journal, 29, Article 159. https://doi.org/10.11604/pamj.2018.29.159.13659
[11]
Fatimata, K., Mamady, D., Sayon, K.A., Soumana, O., Toumin, C., Abdoulaye, C., et al. (2022) Profil de l’Hémogramme chez les PVVIH sous Traitement ARV à Conakry [Original Article: Blood Count Profile of People Living with HIV under Antiretroviral Treatment in Conakry]. Health Sciences and Disease, 23, 68-72. https://hsd-fmsb.org/index.php/hsd/article/view/3950
[12]
Kanté, A.S., Diakité, M., Kouyaté, F., Dambakaté, A., Condé, M.S., Kaba, M., et al. (2023) Profil hématologique des patients VIH/SIDA à l’Hôpital régional de Nzérékoré/Hematological profile of HIV/AIDS patients at the Nzérékoré Regional Hospital [Hematological Profile of HIV/AIDS Patients at the Nzérékoré Regional Hospital]. International Journal of Medical Sciences of Abidjan, 25, 203-207. https://indexmedicus.afro.who.int/iah/fulltext/Profil%20h%C3%A9matologique%20des%20patients%20VIH_SIDA%20%C3%A0%20H%C3%B4pital%20r%C3%A9gional%20de%20Nz%C3%A9r%C3%A9kor%C3%A9%20_Kant%C3%A9%20A%20S%20.pdf
[13]
Coulibaly, B. (2008) Suivi du bilan biologique chez les personnes vivant avec le VIH et le SIDA sous traitement antirétroviral au CESAC de Bamako du 1er Janvier 2009 au 31 Janvier 2010 [Monitoring of Biological Assessments in People Living with HIV and AIDS on Antiretroviral Therapy at the CESAC in Bamako from January 1, 2009 to January 31, 2010]. Ph.D. Thesis, University of Bamako, 110 p. https://bibliosante.ml/handle/123456789/7156
[14]
Noupieng Kamgang, V.J. (2016) Atteintes de la fonction rénale chez les patients VIH sous ARV suivies au service de maladies infectieuses du CHU du Point G [Renal Function Impairment in HIV Patients on ART Followed at the Infectious and Tropical Diseases Department of the CHNU Point G]. Ph.D. Thesis, University of Sciences, Techniques and Technologies of Bamako, 93 p. https://bibliosante.ml/handle/123456789/14136?show=full&locale-attribute=en
[15]
Bozon, M. and Kontula, O. (1997) Initiation sexuelle et genre: Comparaison des évolutions de douze pays européens [Sexual Initiation and Gender: Comparison of Trends in Twelve European Countries]. Population (French Edition), 52, 1367-1400. https://doi.org/10.2307/1534632
[16]
Shako, M.N., Kluyskens, Y. and Kokolomami, J. (2015) Comportements sexuels à risque à Lodja, cité à haute prévalence du VIH/Sida en République Démocratique du Congo [Risky Sexual Behaviors in Lodja, a City with a High HIV/AIDS Prevalence in the Democratic Republic of Congo (DRC)]. Annales des Sciences de la Santé, 1, 3-15. https://revues.imist.ma/index.php/A2S/article/view/3918
[17]
Visseaux, B., Le Hingrat, Q., Damond, F., Charpentier, C. and Descamps, D. (2019) Physiopathology of HIV-2 Infection. Virologie, 23, 277-291. https://doi.org/10.1684/vir.2019.0789
[18]
WHO (2013) Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection: Recommendations for a Public Health Approach. World Health Organization. https://iris.who.int/server/api/core/bitstreams/d32eaf43-2dfc-464f-af77-0ec3d2acbebc/content
[19]
Venter, W.D.F., Moorhouse, M., Sokhela, S., Fairlie, L., Mashabane, N., Masenya, M., et al. (2019) Dolutegravir Plus Two Different Prodrugs of Tenofovir to Treat HIV. New England Journal of Medicine, 381, 803-815. https://doi.org/10.1056/nejmoa1902824
[20]
Zoungrana-Yameogo, W.N., Yonli, C., Compaore, T., Bakiono, F., Belem, A.R., et al. (2025) Current Status of ARV Dispensing among People Living with HIV. Revue MédecineTropicale et Santé Internationale (MTSI), 5, 631.
[21]
Servais, J., Nkoghe, D., Schmit, J., Arendt, V., Robert, I., Staub, T., et al. (2001) HIV-Associated Hematologic Disorders Are Correlated with Plasma Viral Load and Improve under Highly Active Antiretroviral Therapy. JAIDS Journal of Acquired Immune Deficiency Syndromes, 28, 221-225. https://doi.org/10.1097/00042560-200111010-00003
[22]
Takuva, S., Maskew, M., Brennan, A.T., Sanne, I., MacPhail, A.P. and Fox, M.P. (2013) Anemia among HIV-Infected Patients Initiating Antiretroviral Therapy in South Africa: Improvement in Hemoglobin Regardless of Degree of Immunosuppression and the Initiating ART Regimen. Journal of Tropical Medicine, 2013, Article ID: 162950. https://doi.org/10.1155/2013/162950
[23]
Assefa, M., Abegaz, W.E., Shewamare, A., Medhin, G. and Belay, M. (2015) Prevalence and Correlates of Anemia among HIV Infected Patients on Highly Active Anti-Retroviral Therapy at Zewditu Memorial Hospital, Ethiopia. BMC Hematology, 15, Article No. 6. https://doi.org/10.1186/s12878-015-0024-6
[24]
Sagna, Y., Koulidiaty, J., Diallo, I., Sanou, A.F., Bagbila, P.A., Sagna, T., et al. (2014) Laboratory Test Features of Newly Diagnosed Adult HIV-Infected Patients in Ouagadougou (Burkina Faso). Médecine et Santé Tropicales, 24, 307-311. https://doi.org/10.1684/mst.2014.0381
[25]
Mbaye, M.N., Niang, K., Sarr, A., Mbaye, A., Diedhiou, D., Ndao, M., et al. (2011) Aspects épidémiologiques du diabète au Sénégal: Résultats d’une enquête sur les facteurs de risque cardiovasculaire dans la ville de Saint-Louis. Médecine des Maladies Métaboliques, 5, 659-664. https://doi.org/10.1016/s1957-2557(11)70343-1
[26]
Benhamou, Y. (2004) Antiretroviral Therapy and HIV/Hepatitis B Virus Coinfection. Clinical Infectious Diseases, 38, S98-S103. https://doi.org/10.1086/381451
[27]
Weidle, P.J., Moore, D., Mermin, J., Buchacz, K., Were, W., Downing, R., et al. (2008) Liver Enzymes Improve over Twenty-Four Months of First-Line Non-Nucleoside Reverse Transcriptase Inhibitor-Based Therapy in Rural Uganda. AIDS Patient Care and STDs, 22, 787-795. https://doi.org/10.1089/apc.2008.0020
[28]
Iroezindu, M.O., Agbaji, O.O., Daniyam, C.A., Isiguzo, G.C., Isichei, C. and Akanbi, M.O. (2013) Liver Function Test Abnormalities in Nigerian Patients with Human Immunodeficiency Virus and Hepatitis B Virus Co-Infection. International Journal of STD & AIDS, 24, 461-467. https://doi.org/10.1177/0956462412473889
[29]
Deckert, A., Neuhann, F., Klose, C., Bruckner, T., Beiersmann, C., Haloka, J., et al. (2017) Assessment of Renal Function in Routine Care of People Living with HIV on ART in a Resource-Limited Setting in Urban Zambia. PLOS ONE, 12, e0184766. https://doi.org/10.1371/journal.pone.0184766
[30]
Wondifraw Baynes, H., Tegene, B., Gebremichael, M., Birhane, G., Kedir, W. and Biadgo, B. (2016) Assessment of the Effect of Antiretroviral Therapy on Renal and Liver Functions among HIV-Infected Patients: A Retrospective Study. HIV/AIDS—Research and Palliative Care, 9, 1-7. https://doi.org/10.2147/hiv.s120979
[31]
Bocoum, M. (2018) Evolution de la charge virale plasmatique chez les PV VIH 1 après 6 mois de traitement antirétroviral à l’hôpital de Sikasso [Evaluation of Plasma Viral Load in PLHIV after 6 Months of Antiretroviral Treatment at Sikasso Hospital]. Ph.D. Thesis, University of Sciences, Techniques and Technologies of Bamako, 92 p. https://bibliosante.ml/handle/123456789/13260
