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TBBPA暴露的雄性生殖毒性研究进展
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Abstract:
四溴双酚A (tetrabromobisphenol A, TBBPA)是全球使用最广泛的溴代阻燃剂，常用于电子电器、塑料和纺织品等的生产过程。随着这些产品的生产、使用和废弃，TBBPA逐渐进入多种环境介质如土壤、水体、灰尘中。TBBPA已在人类血清和乳汁中被检出，其在人体内蓄积可能造成的健康风险受到关注。随着科技发展，生殖健康问题日益受到关注。其中，雄性生殖系统作为TBBPA暴露的关键靶器官，已成为环境毒理学研究的重要焦点。本文综述了TBBPA的暴露途径，及其在睾丸内的蓄积证据、多层次生殖毒性及核心毒作用机制，为风险评估和干预提供依据。
Tetrabromobisphenol A (TBBPA) is the most widely used brominated flame retardant, commonly employed in the production processes of electronics, plastics, textiles, and other goods. Through the manufacturing, use, and disposal of these products, TBBPA gradually enters various environmental media such as soil, water bodies, and dust. TBBPA has been detected in human serum and breast milk, raising concerns about potential health risks from its accumulation in the human body. With technological advancements, reproductive health issues have garnered increasing attention. Among these, the male reproductive system, as a key target organ for TBBPA exposure, has become a major focus in environmental toxicology research. This review summarizes TBBPA exposure pathways, evidence of its accumulation in testes, multilevel reproductive toxicity, and core toxic mechanisms, providing a basis for risk assessment and intervention strategies.
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