Introduction: This study aims to determine the prevalence of HBV and identify associated demographic and clinical risk factors among blood donors. Methods: This was a cross-sectional study with an analytical focus. Donor demographic data were collected and multivariate logistic regression was performed to identify predictors of HBV positivity. Results: In univariate analysis, age, level of education, risky sexual behaviors, and HIV infection were significantly associated with the outcome of interest. Schooled donors had a significantly lower likelihood compared with non-schooled donors (OR = 0.53; 95% CI: 0.32 - 0.87; p = 0.013), suggesting a protective effect of education. In multivariate analysis, after adjustment for potential confounding factors, age (31 - 40 years and 51 - 60 years), risky sexual behaviors, and HIV infection remained significantly associated with the outcome, while education persisted as an independent protective factor (OR = 0.36; 95% CI: 0.20 - 0.63; p < 0.001). Conclusion: Demographic and clinical factors, such as age, educational level, risky sexual behaviors, and HIV positivity, are significant determinants of HbsAg positivity in blood donors. These results highlight the importance of taking these factors into account in the management of blood donations.
References
[1]
Nambei, W.S., Rawago-Mandjiza, D. and Gbangbangai, E. (2016) Seroepidemiology of HIV, Syphilis and Hepatitis B and C Viruses among Blood Donors in Bangui, Central African Republic. Médecine et Santé Tropicales, 26, 192-198. https://doi.org/10.1684/mst.2016.0553
[2]
Yang, S., Wang, D., Zhang, Y., Yu, C., Ren, J., Xu, K., et al. (2015) Transmission of Hepatitis B and C Virus Infection through Body Piercing. Medicine, 94, e1893. https://doi.org/10.1097/md.0000000000001893
[3]
Sanai, F., Alkhatry, M., Alzanbagi, A. and Kumar, S. (2023) Hepatitis B Virus Infection in Saudi Arabia and the UAE: Public Health Challenges and Their Remedial Measures. Journal of Infection and Public Health, 16, 1410-1417. https://doi.org/10.1016/j.jiph.2023.07.008
[4]
Eko Mba, J.M., Bisseye, C., Ntsame Ndong, J.M., Mombo, L.E., Bengone, C., Mouelet Migolet, G., et al. (2018) Prevalent Hepatitis B Surface Antigen among First-Time Blood Donors in Gabon. PLOS ONE, 13, e0194285. https://doi.org/10.1371/journal.pone.0194285
[5]
Maepa, M.B., Ely, A., Kramvis, A., Bloom, K., Naidoo, K., Simani, O.E., et al. (2022) Hepatitis B Virus Research in South Africa. Viruses, 14, Article 1939. https://doi.org/10.3390/v14091939
[6]
Yang, J.D., Mohamed, E.A., Aziz, A.O.A., Shousha, H.I., Hashem, M.B., Nabeel, M.M., et al. (2017) Characteristics, Management, and Outcomes of Patients with Hepatocellular Carcinoma in Africa: A Multicountry Observational Study from the Africa Liver Cancer Consortium. The Lancet Gastroenterology & Hepatology, 2, 103-111. https://doi.org/10.1016/s2468-1253(16)30161-3
[7]
Loua, A., M.L. Sow, E., Magassouba, F.B., Camara, M. and Baldé, M.A. (2004) Évaluation du risque infectieux résiduel chez les donneurs de sang au Centre national de transfusion sanguine de Conakry. Transfusion Clinique et Biologique, 11, 98-100. https://doi.org/10.1016/j.tracli.2004.01.004
[8]
Fu, M.X., Faddy, H.M., Candotti, D., Groves, J., Saa, P., Styles, C., et al. (2024) International Review of Blood Donation Screening for Anti-HBc and Occult Hepatitis B Virus Infection. Transfusion, 64, 2144-2156. https://doi.org/10.1111/trf.18018
[9]
Maiga, A., Maiga, A. and Al, E. (2024) Prévalence du portage de l’antigène de surface du virus de l’hépatite B chez les sujets dépistés en milieu communautaire dans le district de Bamako au Mali. Revue Malienne d’Infectiologie et de Microbiologie, 19, 33-37. https://doi.org/10.53597/remim.v19i1.2791
[10]
Bouba, G., Avoulou, F.L., Kouayet Foyang, Y.J., et al. (2024) Prevalence of Hepatitis B among Blood Donors in Tokombere (Far North Region, Cameroon). Health Sciences and Disease, 25, 92-98.
[11]
Maquessene, O., Laurindo, O., Chambal, L., Ismael, N. and Mabunda, N. (2025) Serological and Molecular Characterization of the Hepatitis B Virus in Blood Donors in Maputo City, Mozambique. Viruses, 17, Article 94. https://doi.org/10.3390/v17010094
[12]
Barry, M.S., Diallo, M.G., Diallo, S., Boiro, M.Y. and Soumah, L.I. (2023) Circulation du virus de l’hépatite B chez les donneurs de sang dans la Région de Mamou—République de Guinée. International Journal of Biological and Chemical Sciences, 17, 1180-1184. https://doi.org/10.4314/ijbcs.v17i3.32
[13]
Loua, A., Diallo, M., Magassouba, F., Camara, M. and Cisse, A. (2011) Séroprévalence de l’hépatite b chez les donneurs de sang en guinée. Journal of Tropical Medicine, No. 4, 65‑396.
[14]
Sylvestre, P.D.S., Odilon, T.F., Abdoulaye, C., Mamady, D., et al. (2022) Caractéristiques Épidémiologiques et Cliniques des Donneurs de Sang Co-Infectés par les Virus VIH et VHB au Centre National de Transfusion Sanguine de Bangui: Donneurs de sang co-infectés par VIH et VHB à Bangui. Health Sciences and Disease, 23, 46-48.
