Therapeutic Individualization in Menopause: Applications and Strategies for the Use of Hormonal Implants

Therapeutic individualization in menopause requires a careful assessment of risks, benefits, and patient preferences within a context of increasing diversity of available treatment options. In this setting, hormonal implants have gained visibility as a strategy for continuous and sustained hormone delivery; however, they remain associated with regulatory controversies, gaps in scientific evidence, and divergent recommendations among scientific societies. Current evidence suggests potential improvement in vasomotor symptoms, sleep disturbances, cognitive performance, body composition, and quality of life, particularly in women who do not tolerate other routes of administration. Effective therapeutic individualization requires a detailed evaluation of the clinical profile, reproductive history, comorbidities, and patient goals, as well as regular monitoring to assess efficacy and safety. This narrative review examines the use of hormonal implants for the management of menopausal symptoms, emphasizing the need for therapeutic individualization. It explores the physiological basis, clinical efficacy, and safety profile of implants, highlighting benefits such as sustained hormone release and improved treatment adherence, alongside challenges such as variability in formulations. The authors conclude that although implants are a promising strategy, their use requires rigorous patient selection, continuous monitoring, and adherence to safety guidelines.