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Managing the Pregnant Woman with Sickle Cell Disease
—A Practical Guide for the Obstetrician

DOI: 10.4236/ojog.2026.162027, PP. 258-269

Keywords: SCD-Sickle Cell Disease, BUE & CR-Blood Urea, Electrolytes and Creatinine, LFT-Liver Function Tests, CTPA-Computerized Pulmonary Angiogram, FAS-Foetal Anomaly Scan, ACS-Acute Chest Syndrome RCOG VTE Score-Royal College of Obstetricians/Gynaecologists Thromboembolism Score, MEOWS-Modified Enhanced Warning Score, MDT-Multidisciplinary Team, NSAIDS-Nonsteroidal Anti-Inflammatory Drugs

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Abstract:

Sickle cell disease is a multi-systemic, chronic condition characterized by acute episodes (referred to as crisis), persistent anaemia, organ infarction/damage and a shortened lifespan. It is the most common inherited blood disorder in humans and affects millions of people worldwide. Pregnancy in sickle cell patients is fraught with several complications and often results in increased perinatal morbidity and occasionally maternal mortality. Managing a pregnant woman with sickle cell disease can be very challenging. The following is a short update and guide for the busy, practising Obstetrician in a District General Hospital setting who may be faced with such a challenge.

References

[1]  Shegekar, T. and Pajai, S. (2023) A Comprehensive Review of Pregnancy in Sickle Cell Disease. Cureus, 15, e41165.
https://doi.org/10.7759/cureus.41165
[2]  Tebbi, C.K. (2022) Sickle Cell Disease, a Review. Hemato, 3, 341-366.
https://doi.org/10.3390/hemato3020024
[3]  Sikdar, O., Ambulkar, H., Jenkinson, A., Hedley, C., Johns, J., Bhat, R., et al. (2024) Maternal and Infant Outcomes in Women with Sickle Cell Disease: A Matched Cohort Study. Archives of Disease in Childhood—Fetal and Neonatal Edition, 109, 657-659.
https://doi.org/10.1136/archdischild-2024-326848
[4]  Oteng‐Ntim, E., Pavord, S., Howard, R., Robinson, S., Oakley, L., Mackillop, L., et al. (2021) Management of Sickle Cell Disease in Pregnancy. a British Society for Haematology Guideline. British Journal of Haematology, 194, 980-995.
https://doi.org/10.1111/bjh.17671
[5]  Rajuna, S., Atreja, C., Mujalda, A., et al. (2023) The Effect of Sickle Cell Haemoglobinopathy on Pregnancy, Labour, Puerperium and Fetal Outcome. A Retrospective Cohort Study from a Single Centre. Cureus, 15, e34318.
[6]  Mumuni, M., Adutwum-Ofosu, K.K., Arko-Boham, B., Hottor, B.A., Koney, N.K., Adu-Bonsaffoh, K., et al. (2025) Histomorphology of Placentae of Women with Sickle Cell Disease during Pregnancy—A Case Control Study. PLOS ONE, 20, e0319011.
https://doi.org/10.1371/journal.pone.0319011
[7]  Alayed, N., Kezouh, A., Oddy, L. and Abenhaim, H.A. (2013) Sickle Cell Disease and Pregnancy Outcomes: Population-Based Study on 8.8 Million Births. Journal of Perinatal Medicine, 42, 487-492.
https://doi.org/10.1515/jpm-2013-0275
[8]  Baergen, R.N. (2010) Chorionic Villi: Histology and Villous Development. In: Baergen, R.N., Ed., Manual of Pathology of the Human Placenta, Springer, 69-83.
https://doi.org/10.1007/978-1-4419-7494-5_6
[9]  (2021) Guidelines for the Management of Sickle Cell Disease in Pregnancy.
https://b-s-h.org.uk/guidelines/guidelines/gl-management-of-sickle-cell-disease-in-pregnancy
[10]  Oteng-Ntim, E., Ayensah, B., Knight, M. and Howard, J. (2014) Pregnancy Outcome in Patients with Sickle Cell Disease in the UK—A National Cohort Study Comparing Sickle Cell Anaemia (HBSS) with HBSC Disease. British Journal of Haematology, 169, 129-137.
https://doi.org/10.1111/bjh.13270
[11]  Koshy, M. (1995) Sickle Cell Disease and Pregnancy. Blood Reviews, 9, 157-164.
https://doi.org/10.1016/0268-960x(95)90021-7
[12]  Yawn, B.P., Buchanan, G.R., Afenyi-Annan, A.N., Ballas, S.K., Hassell, K.L., James, A.H., et al. (2014) Management of Sickle Cell Disease: Summary of the 2014 Evidence-Based Report by Expert Panel Members. JAMA, 312, 1033-1048.
https://doi.org/10.1001/jama.2014.10517
[13]  Chakravorty, S. and Williams, T.N. (2014) Sickle Cell Disease: A Neglected Chronic Disease of Increasing Global Health Importance. Archives of Disease in Childhood, 100, 48-53.
https://doi.org/10.1136/archdischild-2013-303773

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