The present study aimed to contribute to the valorization of Congolese medicinal drugs and food plants. This study shows that the aqueous extract of Tikoni tea (200 and 400 mg/kg) significantly reduces motor activity and increases the duration of barbiturate-induced sleep in mice compared to diazepam (10 mg/kg). However, diazepam decreased time to sleep onset, whereas the extract increased it. The extract therefore has no hypnotic effect; the increase in latency time could be a stimulating effect. This study also revealed that this tea extract possesses free radical scavenging properties with an IC50 of 8.54 mg/mL, which are thought to be linked to the presence of secondary metabolites in this plant.
References
[1]
Ntandou, G.F., N’Goka, V., N’Goka, V., Boumba, S.L. and Abena, A.A. (2018) Chemical Screening, Acute Toxicity and Analgesic Effect of the Aqueous Extracts of Vitex madiensis Oliv. (Lamiaceae-Viticoïdeae) and Phytolacca dodecandra L’Hérit. (Phytolaccaceae) Leaves. International Journal of Sciences, 4, 1-9. https://doi.org/10.18483/ijsci.1261
[2]
Codoñer-Franch, P., Valls-Bellés, V., Arilla-Codoñer, A. and Alonso-Iglesias, E. (2011) Oxidant Mechanisms in Childhood Obesity: The Link between Inflammation and Oxidative Stress. Translational Research, 158, 369-384. https://doi.org/10.1016/j.trsl.2011.08.004
[3]
Rashid, K., Sinha, K. and Sil, P.C. (2013) An Update on Oxidative Stress-Mediated Organ Pathophysiology. Food and Chemical Toxicology, 62, 584-600. https://doi.org/10.1016/j.fct.2013.09.026
[4]
Kulawik, P., Özogul, F., Glew, R. and Özogul, Y. (2013) Significance of Antioxidants for Seafood Safety and Human Health. Journal of Agricultural and Food Chemistry, 61, 475-491. https://doi.org/10.1021/jf304266s
[5]
Ganapaty, S. and Vidyadhar, K.N. (2002) Phytoconstituants et activités biologiques de Vitex: Une revue. Journal of Natural Remedies, 5, 75-95.
[6]
Yao, J., Fang, S., Liu, R., Oppong, M., Liu, E., Fan, G., et al. (2016) A Review on the Terpenes from Genus Vitex. Molecules, 21, Article 1179. https://doi.org/10.3390/molecules21091179
[7]
Bouquet, A. (1969) Féticheurs et médecines traditionnelles du Congo (Brazzaville). Office de la Recherche Scientifique et Technique Outre-Mer (ORSTOM), 283 p.
[8]
Ngbolua, K. (2020) Microscopic Studies, Mineral Composition and Bioactivity of Vitex madiensis Oliv. (Lamiaceae). Discovery Phytomedicine, 7, 177-185. https://doi.org/10.15562/phytomedicine.2020.149
[9]
Ondo, J.P., Lekana-Douki, J.B., Bongui, J.B., Zang Edou, E.S., Zatra, R., Toure-Ndouo, F.S., et al. (2011) In Vitro Antiplasmodial Activity and Cytotoxicity of Extracts and Fractions of Vitex madiensis, Medicinal Plant of Gabon. Tropical Medicine & International Health, 17, 316-321. https://doi.org/10.1111/j.1365-3156.2011.02922.x
[10]
Zimmermann, M. (1983) Ethical Guidelines for Investigations of Experimental Pain in Conscious Animals. Pain, 16, 109-110. https://doi.org/10.1016/0304-3959(83)90201-4
[11]
Boumba, L.S., Nsonde Ntandou, G.F., Loufoua, A.B., Makambila, M.C. and Abena, A.A. (2018) Toxicité aiguë, effets anti-inflammatoire et analgésique de l’extrait aqueux de Heinsia crinita (Afzel.) G. Taylor (Rubiaceae). Phytothérapie, 16, S8-S16. https://doi.org/10.3166/phyto-2019-0155
[12]
Boungou-Tsona, G., Gainche, M., Decombat, C., Ripoche, I., Bikindou, K., Delort, L., et al. (2023) Chemical Profile, Antioxidant and Anti-Inflammatory Potency of Extracts of Vitex madiensis Oliv. and Crossopteryxfebrifuga (Afzel ex G. Don). Plants, 12, Article 386. https://doi.org/10.3390/plants12020386
[13]
Auniq, R.B.J., Chy, M.N.U., Adnan, M., Chowdhury, M.R., Dutta, T., Ibban, S.S., et al. (2020) Evaluation of Anxiolytic, Sedative, and Antioxidant Activities of Vitex peduncularis Wall. Leaves and Investigation of Possible Lead Compounds through Molecular Docking Study. Advances in Traditional Medicine, 21, 507-518. https://doi.org/10.1007/s13596-020-00461-7
[14]
Nkundineza, J.C., Nsonde Ntandou, G.F., Bassoueka, D.A.J., Boumba, L.S., Makambila, M.C. and Abena, A.A. (2020) Anticonvulsant and Sedative Effects of Cassia alata (Fabaceae) in Mice. Galore International Journal of Health Sciences and Research, 5, 28-37.
[15]
Brand, W., Cuvelier, M.E. and Berset, C. (1995) Utilisation de la méthode des radicaux libres pour évaluer l’activit é antioxydante. Lebensmittel Wissenschaft and Tecnologie, 28, 25-30.
[16]
Fontaine, E., Barnoud, D., Schwebel, C. and Leverve, X. (2002) Place des anti-oxydants dans la nutrition du patient septiqueAntioxidants in critically ill patients. Réanimation, 11, 411-420. https://doi.org/10.1016/s1624-0693(02)00269-4
[17]
Husebye, E.E., Lyberg, T. and Røise, O. (2006) Bone Marrow Fat in the Circulation: Clinical Entities and Pathophysiological Mechanisms. Injury, 37, S8-S18. https://doi.org/10.1016/j.injury.2006.08.036
[18]
Bene, K., Camara, D., Kanga, Y. and Zirihi, G.N. (2018) Potentiel antiradicalaire des extraits de feuilles de Bersama abyssinica Fresen. (Melianthaceae). International Journal of Biological and Chemical Sciences, 11, 2962-2970. https://doi.org/10.4314/ijbcs.v11i6.32
[19]
Naziha, A., Samira, F., Fatma, H., Abir, Z. and Kalthoum, M. (2020) Evaluation comparative de l’activité anti-oxydante des extraits éthanoliques des feuilles de Olea europaea L. de l’Est Algérien. Journal de la Faculté de Médecine d’Oran, 2, 579-586.
[20]
Potterat, O. (1997) Antioxidants and Free Radical Scavengers of Natural Origin. Current Organic Chemistry, 1, 415-440. https://doi.org/10.2174/1385272801666220126162734
[21]
Sies, H. (1997) Oxidative Stress: Oxidants and Antioxidants. Experimental Physiology, 82, 291-295. https://doi.org/10.1113/expphysiol.1997.sp004024
[22]
Sarr, S., Fall, A., Gueye, R., Diop, A., Diatta, K., Diop, N., et al. (2015) Etude de l’activité antioxydante des extraits des feuilles de Vitex doniana (Verbenacea). International Journal of Biological and Chemical Sciences, 9, 1263-1269. https://doi.org/10.4314/ijbcs.v9i3.11
[23]
Marder, M. (2012) Flavonoids as GABAA Receptor Ligands: The Whole Story? Journal of Experimental Pharmacology, 2012, 9-24. https://doi.org/10.2147/jep.s23105
[24]
Madhura, M., Amrita, B., Meenal, R. and Kausani, L. (2016) Herbal CNS Stimulants. International Journal of Herbal Medicine, 4, 109-116.