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Clinical Efficacy of Majing Zhike Granules for Postoperative Cough in Lung Cancer Patients

DOI: 10.4236/jbm.2026.141028, PP. 376-385

Keywords: Lung Cancer, Postoperative Cough, Majing Zhike Granules, Leicester Cough Questionnaire, Visual Analogue Scale, Cough Symptom Score

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Abstract:

Objective: To evaluate the efficacy of Majing Zhike Granules in relieving postoperative cough in lung cancer patients using multidimensional assessment tools. Methods: Sixty patients who developed cough after radical lung cancer surgery were randomly assigned to a control group or an intervention group (n = 30 each). The control group received routine postoperative and antitussive care, whereas the intervention group additionally received Majing Zhike Granules for 2 weeks. Changes in the Cough Symptom Score (CSS), Visual Analogue Scale (VAS), and the Leicester Cough Questionnaire (LCQ) were compared between groups, and adverse events were recorded. Results: After 2 weeks of treatment, the intervention group exhibited significantly lower CSS and VAS scores than the control group (P < 0.01). Scores across all LCQ domains and the total LCQ score were significantly higher in the intervention group (P < 0.01). Conclusion: Majing Zhike Granules markedly alleviate postoperative cough and improve cough-related quality of life in lung cancer patients, demonstrating good tolerability and potential clinical utility.

References

[1]  Sun, D., Hu, J., Li, X., He, J., Xu, L., Fu, X., et al. (2023) Real-World Surgical Treatment Patterns and Clinical Outcomes in Patients with Stages IA-IIIA Non-Small Cell Lung Cancer: A Retrospective Multicentric Observational Study Involving 11,958 Patients. Journal of Cancer Research and Clinical Oncology, 149, 8213-8223.
https://doi.org/10.1007/s00432-023-04729-8
[2]  Wu, Y., Song, W., Zhu, D., Wang, Y. and Che, G. (2023) Risk Factors for Cough after Pulmonary Resection. World Journal of Surgical Oncology, 21, Article No. 348.
https://doi.org/10.1186/s12957-023-03235-y
[3]  Huang, Y., Chen, M., Wu, Z., Liu, P., Zhang, S., Chen, C., et al. (2024) Postoperative Chronic Operation-Related Symptoms after Minimally Invasive Lung Surgery: A Prospective Observational Protocol. BMJ Open, 14, e082412.
https://doi.org/10.1136/bmjopen-2023-082412
[4]  Zhang, S., Deng, Y., Xiang, X., Xu, Q., Hu, L., Xia, M., et al. (2025) Postoperative Symptom Network Analysis in Non-Small Cell Lung Cancer Patients: A Cross-Sectional Study. BMC Pulmonary Medicine, 25, Article No. 244.
https://doi.org/10.1186/s12890-025-03711-z
[5]  Sun, X., Lan, Z., Shi, Q., Wu, H., Lu, G., Qiu, Y., et al. (2024) Persistent Cough after Pulmonary Resection: Minor Issue, Major Hurdle. Heliyon, 10, e31338.
https://doi.org/10.1016/j.heliyon.2024.e31338
[6]  Zhou, X., Lei, C., Wei, X., Dai, W., Xu, W., Ao, Y., et al. (2024) Patient’s Experiences of Coughing after Lung Cancer Surgery: A Multicenter Qualitative Study. Cancer Medicine, 13, e6993.
https://doi.org/10.1002/cam4.6993
[7]  Ohtsuka, T. (2024) The Association between Postoperative Persistent Cough and Bronchial Angle. Annals of Surgical Oncology, 31, 4843-4844.
https://doi.org/10.1245/s10434-024-15256-2
[8]  Sun, X., Lan, Z., Li, S., Huang, S., Zeng, C., Wu, J., et al. (2023) Trajectories and Risk Factors of Persistent Cough after Pulmonary Resection: A Prospective Two-Center Study. Thoracic Cancer, 14, 3503-3510.
https://doi.org/10.1111/1759-7714.15147
[9]  Dinic, V.D., Stojanovic, M.D., Markovic, D., Cvetanovic, V., Vukovic, A.Z. and Jankovic, R.J. (2018) Enhanced Recovery in Thoracic Surgery: A Review. Frontiers in Medicine, 5, Article 14.
https://doi.org/10.3389/fmed.2018.00014
[10]  Trabalza Marinucci, B., D’Andrilli, A., Menna, C., Fiorelli, S., Siciliani, A., Andreetti, C., et al. (2025) Phrenic Nerve Infiltration: A Good Practice to Combine Pulmonary Expansion and Pain Control in Patients with High Risk of Prolonged Air Leak. JTCVS Open, 23, 349-357.
https://doi.org/10.1016/j.xjon.2024.10.026
[11]  Bertolaccini, L., Mohamed, S., Uslenghi, C., Chiari, M., Girelli, L., Lo Iacono, G., et al. (2023) A Practical Assessment of the Postoperative Management in Lung Cancer Surgery. Journal of Personalized Medicine, 13, Article 358.
https://doi.org/10.3390/jpm13020358
[12]  Qi, A., He, Y., Gu, Y., Zhang, C., Qin, X., Wang, Y., et al. (2024) Chinese Herbal Medicine Combined with Liuzijue Exercise in Physiological Rehabilitation after Video-Assisted Lung Lobectomy for Cancer: A Prospective Propensity Score Matching Study. Integrative Cancer Therapies, 23, 1-10.
https://doi.org/10.1177/15347354241261977
[13]  Zhu, P.F., Jiang, G.P., Zhang, Y.J. and Su, G.F. (2025) Efficacy of Yiqi Yangxue Formula on Postoperative Cough after Radical Resection of Non-Small Cell Lung Cancer and Its Effect on Inflammatory Cytokines. Shaanxi Journal of Traditional Chinese Medicine, 46, 499-503.
[14]  Wu, X.B., Xue, S.G. and Li, Q.Q. (2024) Clinical Effect of Modified Bufei Decoction on Postoperative Cough in Patients with Non-Small Cell Lung Cancer. Modern Medicine and Health Research (Electronic Edition), 8, 106-108.
[15]  Chen, J.W. and Cai, S.Z. (2022) Effect of Majing Zhike Granules on TRPV1 Expression in Lung Tissue of Guinea Pigs with Cough-Variant Asthma. Clinical Research of Traditional Chinese Medicine, 14, 30-33.
[16]  Wang, S.C., Ye, Y.Y. and Lu, F. (2023) Majing Zhike Granules in the Treatment of Wind-Predominant Spastic Type Cough-Variant Asthma: Analysis of 30 Cases. Fujian Journal of Traditional Chinese Medicine, 54, 63-64, 67.
[17]  Committee on Cancer Rehabilitation and Palliative Care and Chinese Anti-Cancer Association (2021) Chinese Expert Consensus on Diagnosis and Treatment of Lung Cancer-Related Cough. National Medical Journal of China, 101, 2751-2759.
[18]  Asthma Group of the Respiratory Disease Branch and Chinese Medical Association (2016) Guidelines for the Diagnosis and Treatment of Cough (2015). Chinese Journal of Tuberculosis and Respiratory Diseases, 39, 323-354.
[19]  Yang, C.F., et al. (2024) Experience of National Master of Traditional Chinese Medicine Chao Enxiang in Treating Postoperative Cough after Lung Cancer Surgery. Tianjin Journal of Traditional Chinese Medicine, 41, 1-5.
[20]  Zhu, W.J. and Zha, M.B. (2025) Experience of Zha Mingbao in Treating Postoperative Cough after Lung Cancer Surgery. Chinese Journal of Library and Information Science for Traditional Chinese Medicine, 49, 181-184.
[21]  Rui, H.L., Zhang, N.Z. and Zhang, R. (2023) Preliminary Analysis of Professor Zhang Nianzhi’s Experience of “Treating Qi First” in Managing Postoperative Cough after Lung Cancer Surgery. Chinese Folk Therapy, 31, 27-30.
[22]  Lu, W., Gu, H.W., Yang, X.D. and Zhang, P. (2025) Treatment of Postinfectious Cough Based on the “Wind-Cough” Theory. Research of Traditional Chinese Medicine, 38, 12-15.
[23]  Huang, Y.Q., Ye, Y.Y., Wang, S.C., Lin, S.M. and Lu, F. (2025) Effects of Majing Zhike Granules on Serum IL-6 and TNF-α Levels and Airway Wall Thickness in Rats with Cough-Variant Asthma. Research of Traditional Chinese Medicine, 38, 53-57.
[24]  Chen, J.W. and Cai, S.Z. (2023) Mechanism of Majing Zhike Granules in Treating Cough-Variant Asthma Based on TSLP/PAR2/TRPV1/NF-AT Signaling Pathways. Clinical Research of Traditional Chinese Medicine, 15, 69-74.
[25]  Lin, W.J. (2020) Clinical Observation of Majing Zhike Granules in Treating Postinfectious Cough of “Wind Invading the lung” Pattern. Master’s Thesis, Fujian University of Traditional Chinese Medicine.

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