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能量代谢重编程调控破骨细胞分化的研究进展
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Abstract:
破骨细胞是高效吸收骨组织的主要细胞，在骨重塑过程中发挥重要作用。破骨细胞形成和活性的失调与多种骨病相关，如骨质疏松症、骨硬化症、类风湿关节炎和牙周炎。破骨细胞的代谢重编程不仅支持单核祖细胞向多核破骨细胞的表型转变，还为它们的分化及进行骨吸收功能提供必要能量。本文通过对代谢重编程在破骨细胞分化过程中的研究进行回顾，对不同代谢途径和机制进行综述。
Osteoclasts are the primary cells responsible for efficient bone resorption and play a crucial role in bone remodeling. Dysregulation of osteoclast formation and activity is associated with various bone diseases, such as osteoporosis, osteopetrosis, rheumatoid arthritis and periodontitis. Metabolic reprogramming in osteoclasts not only supports the phenotypic transformation of mononuclear progenitors into multinucleated osteoclasts but also provides the necessary energy for their differentiation and bone-resorbing functions. This article reviews studies on metabolic reprogramming during osteoclast differentiation and summarizes the related metabolic pathways and mechanisms.
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