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代谢重编程与肺纤维化：靶向糖酵解的治疗药物
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Abstract:
肺纤维化是组织损伤后异常修复的核心病理结局，可导致肺组织功能进行性衰竭。近年研究深入揭示，糖酵解代谢重编程在此过程中扮演着关键角色。靶向干预糖酵解通路，能够有效调控与之相关的炎症反应、上皮–间质转化、巨噬细胞极化及细胞外基质沉积等多个核心环节，从而延缓肺纤维化进程。基于该策略开发的化合物在临床前模型中已展现出明确治疗潜力，标志着以代谢干预为代表的肺纤维化新疗法前景广阔。
Pulmonary fibrosis represents a core pathological outcome of aberrant repair following tissue injury, leading to progressive functional failure of the lungs. Recent research has elucidated the critical role of glycolytic metabolic reprogramming in this process. Targeted intervention of the glycolytic pathway can effectively modulate key pathological events associated with it, including the inflammatory response, epithelial-mesenchymal transition, macrophage polarization, and extracellular matrix deposition, thereby attenuating the progression of pulmonary fibrosis. Compounds developed based on this strategy have demonstrated significant therapeutic potential in preclinical models, highlighting the promising prospects of metabolism-focused interventions as novel therapies for pulmonary fibrosis.
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