Recurrent Implantation Failure (RIF) affects approximately 10% of in vitro fertilization-embryo transfer (IVF-ET) patients worldwide, posing a significant challenge for reproductive physicians globally. Its etiology is complex and diverse, with maternal factors being paramount, particularly endometrial receptivity (ER). Platelet-rich plasma (PRP), an emerging regenerative medicine therapy, is rich in growth factors and cytokines. Studies have shown that intrauterine PRP infusion can improve endometrial condition and increase embryo implantation rates. This article systematically reviews the application value and safety of intrauterine PRP in RIF patients.
References
[1]
Sun, Y., Zhang, Y., Ma, X., Jia, W. and Su, Y. (2021) Determining Diagnostic Criteria of Unexplained Recurrent Implantation Failure: A Retrospective Study of Two vs Three or More Implantation Failure. Frontiers in Endocrinology, 12, Article 619437. https://doi.org/10.3389/fendo.2021.619437
[2]
Cimadomo, D., de los Santos, M.J., Griesinger, G., Lainas, G., Le Clef, N., McLernon, D.J., et al. (2023) ESHRE Good Practice Recommendations on Recurrent Implantation Failure. Human Reproduction Open, 2023, hoad023. https://doi.org/10.1093/hropen/hoad023
[3]
Craciunas, L., Gallos, I., Chu, J., Bourne, T., Quenby, S., Brosens, J.J., et al. (2019) Conventional and Modern Markers of Endometrial Receptivity: A Systematic Review and Meta-Analysis. Human Reproduction Update, 25, 202-223. https://doi.org/10.1093/humupd/dmy044
[4]
Hua, Y.Z., Huang, C. and Sun, Y. (2022) Research Progress on the Application Effect of Intrauterine Infusion Therapy in Assisted Reproductive Technology. Guangxi Medical Journal, 44, 2798-2801.
[5]
Amable, P.R., Carias, R.B.V., Teixeira, M.V.T., da Cruz Pacheco, Í., Corrêa do Amaral, R.J.F., Granjeiro, J.M., et al. (2013) Platelet-rich Plasma Preparation for Regenerative Medicine: Optimization and Quantification of Cytokines and Growth Factors. Stem Cell Research & Therapy, 4, Article No. 67. https://doi.org/10.1186/scrt218
[6]
Kumbak, B., Erden, H., Tosun, S., Akbas, H., Ulug, U. and Bahçeci, M. (2009) Outcome of Assisted Reproduction Treatment in Patients with Endometrial Thickness Less than 7 mm. Reproductive BioMedicine Online, 18, 79-84. https://doi.org/10.1016/s1472-6483(10)60428-2
[7]
Aghajanova, L., Houshdaran, S., Balayan, S., Manvelyan, E., Irwin, J.C., Huddleston, H.G., et al. (2018) In Vitro Evidence That Platelet-Rich Plasma Stimulates Cellular Processes Involved in Endometrial Regeneration. Journal of Assisted Reproduction and Genetics, 35, 757-770. https://doi.org/10.1007/s10815-018-1130-8
[8]
Gentilini, D., Busacca, M., Di Francesco, S., Vignali, M., Viganò, P. and Di Blasio, A.M. (2007) PI3K/Akt and ERK1/2 Signalling Pathways Are Involved in Endometrial Cell Migration Induced by 17β-Estradiol and Growth Factors. MHR: Basic Science of Reproductive Medicine, 13, 317-322. https://doi.org/10.1093/molehr/gam001
[9]
Kim, M.K., Yoon, J.A., Yoon, S.Y., Park, M., Lee, W.S., Lyu, S.W., et al. (2022) Human Platelet-Rich Plasma Facilitates Angiogenesis to Restore Impaired Uterine Environments with Asherman’s Syndrome for Embryo Implantation and Following Pregnancy in Mice. Cells, 11, Article 1549. https://doi.org/10.3390/cells11091549
[10]
Tandulwadkar, S., Naralkar, M., Surana, A., Selvakarthick, M. and Kharat, A. (2017) Autologous Intrauterine Platelet-Rich Plasma Instillation for Suboptimal Endometrium in Frozen Embryo Transfer Cycles: A Pilot Study. JournalofHumanReproductiveSciences, 10, 208-212. https://doi.org/10.4103/jhrs.jhrs_28_17
[11]
Chang, Y.J., Zhang, X.L., Yang, X., et al. (2016) The Effect of Platelet-Rich Plasma on Endometrial Proliferation and Pregnancy Outcomes. Practical Journal of Obstetrics and Gynecology, 32, 445-449.
[12]
Maleki-Hajiagha, A., Razavi, M., Rouholamin, S., Rezaeinejad, M., Maroufizadeh, S. and Sepidarkish, M. (2020) Intrauterine Infusion of Autologous Platelet-Rich Plasma in Women Undergoing Assisted Reproduction: A Systematic Review and Meta-Analysis. Journal of Reproductive Immunology, 137, Article 103078. https://doi.org/10.1016/j.jri.2019.103078
[13]
Serdarogullari, M., Raad, G., Makieva, S., Liperis, G., Fraire-Zamora, J.J. and Celik-Ozenci, C. (2024) Revitalizing Female Fertility: Platelet-Rich Plasma—Hype or Hope? Reproductive BioMedicine Online, 49, Article 103813. https://doi.org/10.1016/j.rbmo.2024.103813
[14]
Johnston-MacAnanny, E.B., Hartnett, J., Engmann, L.L., Nulsen, J.C., Sanders, M.M. and Benadiva, C.A. (2010) Chronic Endometritis Is a Frequent Finding in Women with Recurrent Implantation Failure after in Vitro Fertilization. Fertility and Sterility, 93, 437-441. https://doi.org/10.1016/j.fertnstert.2008.12.131
[15]
Demirdag, E., Guler, I., Cevher Akdulum, M.F., Sahin, E., Erdem, O., Erdem, A., et al. (2021) Subsequent IVF Outcomes Following Antibiotic Therapy for Chronic Endometritis in Patients with Recurrent Implantation Failure. Journal of Obstetrics and Gynaecology Research, 47, 4350-4356. https://doi.org/10.1111/jog.15037
[16]
Jang, H., Myoung, S.M., Choe, J.M., Kim, T., Cheon, Y., Kim, Y.M., et al. (2017) Effects of Autologous Platelet-Rich Plasma on Regeneration of Damaged Endometrium in Female Rats. Yonsei Medical Journal, 58, 1195-1203. https://doi.org/10.3349/ymj.2017.58.6.1195
[17]
Sfakianoudis, K., Simopoulou, M., Nitsos, N., Lazaros, L., Rapani, A., Pantou, A., et al. (2019) Successful Implantation and Live Birth Following Autologous Platelet-Rich Plasma Treatment for a Patient with Recurrent Implantation Failure and Chronic Endometritis. In Vivo, 33, 515-521. https://doi.org/10.21873/invivo.11504
[18]
Li, F.H., Cui, Y.Q., Zhao, D.M., et al. (2024) Outcome Study of Five Cases Receiving in Vitro Fertilization after Treatment of Intrauterine Platelet-Rich Plasma (PRP) for Chronic Endometritis. Panminerva Medica, 66, 105-107.
[19]
Kim, J.K., Bao, S., Lee, S.K., et al. (2014) Immunological Modes of Pregnancy Loss: Inflammation, Immune Effectors, and Stress. AmericanJournalofReproductiveImmunology, 72, 129-140. https://doi.org/10.1111/aji.12234
[20]
Chen, S.Q., Liu, J.J. and Cui, F. (2023) The Effect of Platelet-Rich Plasma Treatment on Peripheral Blood Th1 and Th2 Cytokine Levels and Pregnancy Outcomes in Patients with Recurrent Embryo Implantation Failure. Chinese Medical Journal, 58, 806-809.
[21]
Nazari, L., Salehpour, S., Hoseini, S. and Zadehmodarres, S. (2016) Effects of Autologous Platelet-Rich Plasma on Implantation and Pregnancy in Repeated Implantation Failure: A Pilot Study. International Journal of Reproductive BioMedicine, 14, 625-628. https://doi.org/10.29252/ijrm.14.10.625
[22]
Nazari, L., Salehpour, S., Hosseini, M.S. and Hashemi Moghanjoughi, P. (2020) The Effects of Autologous Platelet-Rich Plasma in Repeated Implantation Failure: A Randomized Controlled Trial. Human Fertility, 23, 209-213. https://doi.org/10.1080/14647273.2019.1569268
[23]
Nazari, L., Salehpour, S., Hosseini, S., Sheibani, S. and Hosseinirad, H. (2021) The Effects of Autologous Platelet-Rich Plasma on Pregnancy Outcomes in Repeated Implantation Failure Patients Undergoing Frozen Embryo Transfer: A Randomized Controlled Trial. Reproductive Sciences, 29, 993-1000. https://doi.org/10.1007/s43032-021-00669-1
[24]
Kim, H., Shin, J.E., Koo, H.S., Kwon, H., Choi, D.H. and Kim, J.H. (2019) Effect of Autologous Platelet-Rich Plasma Treatment on Refractory Thin Endometrium during the Frozen Embryo Transfer Cycle: A Pilot Study. Frontiers in Endocrinology, 10, Article 61. https://doi.org/10.3389/fendo.2019.00061
[25]
Zamaniyan, M., Peyvandi, S., Heidaryan Gorji, H., Moradi, S., Jamal, J., Yahya Poor Aghmashhadi, F., et al. (2021) Effect of Platelet-Rich Plasma on Pregnancy Outcomes in Infertile Women with Recurrent Implantation Failure: A Randomized Controlled Trial. GynecologicalEndocrinology, 37, 141-145. https://doi.org/10.1080/09513590.2020.1756247
[26]
Allahveisi, A., Seyedoshohadaei, F., Rezaei, M., Bazrafshan, N. and Rahimi, K. (2020) The Effect of Platelet-Rich Plasma on the Achievement of Pregnancy during Frozen Embryo Transfer in Women with a History of Failed Implantation. Heliyon, 6, e03577. https://doi.org/10.1016/j.heliyon.2020.e03577
[27]
Fitzpatrick, J., Bulsara, M.K., McCrory, P.R., et al. (2017) Analysis of Platelet-Rich Plasma Extraction: Variations in Platelet and Blood Components between 4 Common Commercial Kits. Orthopaedic Journal of Sports Medicine, 5.
[28]
Fadadu, P.P., Mazzola, A.J., Hunter, C.W. and Davis, T.T. (2019) Review of Concentration Yields in Commercially Available Platelet-Rich Plasma (PRP) Systems: A Call for PRP Standardization. Regional Anesthesia & Pain Medicine, 44, 652-659. https://doi.org/10.1136/rapm-2018-100356
[29]
Bos-Mikich, A., de Oliveira, R. and Frantz, N. (2018) Platelet-Rich Plasma Therapy and Reproductive Medicine. Journal of Assisted Reproduction and Genetics, 35, 753-756. https://doi.org/10.1007/s10815-018-1159-8
[30]
Saqlain, N., Mazher, N., Fateen, T. and Siddique, A. (2023) Comparison of Single and Double Centrifugation Methods for Preparation of Platelet-Rich Plasma (PRP). Pakistan Journal of Medical Sciences, 39, 634-637. https://doi.org/10.12669/pjms.39.3.7264
[31]
Chang, Y., Li, J., Chen, Y., et al. (2015) Autologous Platelet-Rich Plasma Promotes Endometrial Growth and Improves Pregnancy Outcome during in Vitro Fertilization. International Journal of Clinical and Experimental Medicine, 8, 1286-1290.
