|
|
新生儿支气管肺发育不良危险因素和诊治进展
|
Abstract:
支气管肺发育不良(bronchopulmonary dysplasia, BPD)又称为新生儿慢性肺部疾病，是指任何需要用氧气吸入超过28天的新生儿，伴有肺部影像学的改变。随着新生儿重症监护病房(neonatal intensive care unit, NICU)的条件改善与近些年新生儿的救治水平不断提高，目前新生儿存活率明显提高，支气管发育不良也逐渐常见。一直以来，新生儿支气管肺发育不良是困扰临床儿科工作人员的难题。本文对支气管肺发育不良危险因素和诊治情况进行分析。
Broncho pulmonary dysplasia (BPD), also known as neonatal chronic lung disease, refers to any newborn who needs oxygen support for more than 28 days, accompanied by pulmonary imaging changes. With the improvement of neonatal intensive care unit (NICU) conditions and the improvement of neonatal treatment, the survival rate of neonates has been significantly increased, and bronchial dysplasia is becoming more and more common. Neonatal broncho pulmonary dysplasia has always been a difficult problem for clinical pediatric medical workers. This article introduces the risk factors, diagnosis and treatment of broncho pulmonary dysplasia.
| [1] | Bhandari, A. and Bhandari, V. (2009) Pitfalls, Problems, and Progress in Bronchopulmonary Dysplasia. Pediatrics, 123, 1562-1573. https://doi.org/10.1542/peds.2008-1962 |
| [2] | Stoll, B.J., Hansen, N.I., Bell, E.F., Walsh, M.C., Carlo, W.A., Shankaran, S., et al. (2015) Trends in Care Practices, Morbidity, and Mortality of Extremely Preterm Neonates, 1993-2012. Journal of the American Medical Association, 314, 1039-1051. https://doi.org/10.1001/jama.2015.10244 |
| [3] | Sehgal, A., Gwini, S.M., Menahem, S., Allison, B.J., Miller, S.L. and Polglase, G.R. (2019) Preterm Growth Restriction and Bronchopulmonary Dysplasia: The Vascular Hypothesis and Related Physiology. The Journal of Physiology, 597, 1209-1220. https://doi.org/10.1113/jp276040 |
| [4] | Groene, S.G., Spekman, J.A., te Pas, A.B., Heijmans, B.T., Haak, M.C., van Klink, J.M.M., et al. (2021) Respiratory Distress Syndrome and Bronchopulmonary Dysplasia after Fetal Growth Restriction: Lessons from a Natural Experiment in Identical Twins. EClinicalMedicine, 32, Article 100725. https://doi.org/10.1016/j.eclinm.2021.100725 |
| [5] | 罗靖侠, 王永明, 许凤芝, 等. 早产儿支气管肺发育不良的危险因素分析[J]. 宁夏医学杂志, 2025, 47(7): 611-615. |
| [6] | Xu, J.Y., Fu, Y.K., Wang, F., et al. (1992) The Clinical Value of Lung Ultrasound in Premature Infants with Bronchopulmonary Dysplasia. Revista da Associação Médica Brasileira, 69, 262-266. https://doi.org/10.1590/1806-9282.20220960 |
| [7] | Nascimento, C.P., Maia, L.P., Alves, P.T., Paula, A.T.D., Cunha Junior, J.P., Abdallah, V.O.S., et al. (2021) Invasive Mechanical Ventilation and Biomarkers as Predictors of Bronchopulmonary Dysplasia in Preterm Infants. Jornal de Pediatria, 97, 280-286. https://doi.org/10.1016/j.jped.2020.03.006 |
| [8] | 祝巍, 孙智勇, 杜娟, 等. 新生儿支气管肺发育不良的临床诊治研究进展[J]. 中外女性健康研究, 2022(23): 10-12. |
| [9] | Consiglio, A. and Bennett, J. (2020) Intraventricular Hemorrhage and Neurodevelopmental Outcomes in Extremely Preterm Infants. Neonatology, 117, 74-83. |
| [10] | 虞嘉碧, 李娟. 重度支气管肺发育不良的管理现状[J]. 中国小儿急救医学, 2021, 28(1): 55-58. |
| [11] | 陈瑛, 彭晓艳, 韩同英, 等. 早产儿嗜酸性粒细胞增多症与支气管肺发育不良的相关性[J]. 中华新生儿科杂志, 2021, 36(1): 14-19. |
| [12] | Kennedy, K.A., Cotten, C.M., Watterberg, K.L. and Carlo, W.A. (2016) Prevention and Management of Bronchopulmonary Dysplasia: Lessons Learned from the Neonatal Research Network. Seminars in Perinatology, 40, 348-355. https://doi.org/10.1053/j.semperi.2016.05.010 |
| [13] | Stevens, T.P., Blennow, M., Myers, E.H., et al. (2007) Early Surfactant Administration with Brief Ventilation vs Selective Surfactant and Continued Mechanical Ventilation for Preterm Infants with or at Risk for Espiratory Distress Syndrome. Cochrane Database System Reviews, 17, 82-115. |
| [14] | Vadivel, A., Aschner, J.L., Rey-Parra, G.J., Magarik, J., Zeng, H., Summar, M., et al. (2010) L-Citrulline Attenuates Arrested Alveolar Growth and Pulmonary Hypertension in Oxygen-Induced Lung Injury in Newborn Rats. Pediatric Research, 68, 519-525. https://doi.org/10.1203/pdr.0b013e3181f90278 |
| [15] | Lodha, A., Seshia, M., McMillan, D.D., Barrington, K., Yang, J., Lee, S.K., et al. (2015) Association of Early Caffeine Administration and Neonatal Outcomes in Very Preterm Neonates. JAMA Pediatrics, 169, 33-38. https://doi.org/10.1001/jamapediatrics.2014.2223 |
| [16] | Stewart, A. and Brion, L.P. (2011) Intravenous or Enteral Loop Diuretics for Preterm Infants with (or Developing) Chronic Lung Disease. The Cochrane Database of Systematic Reviews, 9, D1453. |
| [17] | Migliori, C., Gancia, P., Garzoli, E., Spinoni, V. and Chirico, G. (2009) The Effects of Helium/oxygen Mixture (heliox) before and after Extubation in Long-Term Mechanically Ventilated Very Low Birth Weight Infants. Pediatrics, 123, 1524-1528. https://doi.org/10.1542/peds.2008-0937 |
| [18] | 黄高展, 刘春华. 间充质干细胞治疗早产儿支气管肺发育不良的研究进展[J]. 汕头大学医学院学报, 2022, 35(2): 123-125. |
| [19] | Zhao, Y., Zhu, X.Y., Song, T., et al. (2021) Mesenchymal Stem Cells Protect Renal Tubular Cells via TSG-6 Regulating Macrophage Function and Phenotype Switching. American Journal of Physiology-Renal Physiology, 320, F454-F463. https://doi.org/10.1152/ajprenal.00426.2020 |
| [20] | 岳银艳. 间充质干细胞对支气管肺发育不良防治的研究进展[J]. 国际生物制品学杂志, 2022, 45(2): 116-120. |
| [21] | 谢可瑾, 董明月, 白静萱, 等. 间充质干细胞治疗支气管肺发育不良作用机制的研究进展[J]. 中国当代儿科杂志, 2022, 24(1): 108-114. |
