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Pharmacy Information 2026
骨骼肌萎缩的病理机制与药物防治
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Abstract:
骨骼肌不仅参与机体的运动功能，还是重要的能量代谢组织，对人体自身的新陈代谢和能量转换等有着重要的调控作用，从而对人体日常的运动以及整体水平的健康产生着重要的影响。但是，在多种病理因素以及疾病的影响下，骨骼肌会发生病理的改变，导致肌肉疾病的形成，例如骨骼肌萎缩。骨骼肌萎缩不仅会影响患者正常的肢体活动从而导致患者的生活质量下降还会给社会带来巨大的负担。本文就骨骼肌萎缩的主要发病机制进行了综述并进一步概括了相关的药物防治，旨在深化对骨骼肌萎缩发病机制的认识以及为其防治提供新的理论支撑。
Skeletal muscle not only plays a crucial role in motor activity but also serves as a vital tissue in regulating the body’s own metabolism and energy conversion, thereby influencing daily movement and overall health. However, under the influence of various pathological factors and diseases, skeletal muscle undergoes pathological changes, leading to the development of muscular diseases, such as muscle atrophy. Skeletal muscle atrophy can impair normal limb movement in patients, leading to a decline in their quality of life and placing a heavy burden on society. This article reviews several main pathogeneses of skeletal muscle atrophy and further summarizes the relevant pharmacotherapeutic approaches, aiming to expand the understanding of skeletal muscle atrophy and provide new theoretical support for its prevention and treatment.
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