ENT Infections and Skin Infections Due to Streptococcus pyogenes: Prevalence and Antibiotic Sensitivity Profile of Strains Isolated at Albert Royer Children’s Hospital, Dakar-Senegal
Background:Streptococcus pyogenes or Groupe A Streptococcus (GAS) infections constitute a real public health problem due to their frequency and the post-infectious complications they cause. Thus, it is necessary to update epidemiological data for better management. This study aimed to determine the prevalence of GAS in skin and ENT infections and to study their antibiotic susceptibility profile. Methods: It was a prospective study of Streptococcus pyogenes skin and ENT infections at Albert Royer Children’s Hospital. Bacterial isolation and identification were performed using standard bacteriological techniques. Data were entered using Excel 2010 software and analyzed using Epi info 7.2 software. Results: A total of 245 patients were included, with a mean age of 5.49 years and a standard deviation of 3.9. The proportion of male patients was higher (51%), and the majority were aged from 0 to 3 years. The prevalence of GAS infection was 6.93%. Streptococcus pyogenes strains had good susceptibility to penicillin G (100%), cefotaxime (100%), ceftriaxone (100%), ceftazidime (100%), chloramphenicol, and vancomycin (100%). The activity of erythromycin was good (87%), as well as that of ampicillin (86%), lincomycin (75%), rifampicin (71%) and pefloxacin (67%). However, poor activity was noted for cotrimoxazole (43%), norfloxacin (33%) and resistance to all strains for gentamicin. Conclusion: The prevalence of Streptococcus pyogenes infections was low. Antibiotic susceptibility was variable. Penicillin G, cefotaxime, ceftriaxone, ceftazidime, chloramphenicol, and vancomycin had very good activity. However, the activity of cotrimoxazole, norfloxacin, and gentamicin was low.
References
[1]
Efstratiou, A. (2000) Group a Streptococci in the 1990s. JournalofAntimicrobialChemotherapy, 45, 3-12. https://doi.org/10.1093/jac/45.suppl_1.3
[2]
Bidet, P., Plainvert, C., Doit, C., Mariani-Kurkdjian, P., Bonacorsi, S., Lepoutre, A., et al. (2010) Infections à Streptococcus pyogenes ou streptocoque du groupe a chez l’enfant: Données du Centre national de référence (CNR). Archives de Pédiatrie, 17, 201-208. https://doi.org/10.1016/j.arcped.2009.10.005
[3]
Carapetis, J.R., Steer, A.C., Mulholland, E.K. and Weber, M. (2005) The Global Burden of Group a Streptococcal Diseases. TheLancetInfectiousDiseases, 5, 685-694. https://doi.org/10.1016/s1473-3099(05)70267-x
[4]
WHO (2018) Rheumatic Fever and Rheumatic Heart Disease: Report of the Director-Gener. https://apps.who.int/gb/ebwha/pdf_files/WHA74/A74_40-fr.pdf
[5]
Russo, B.T., Ayinuola, Y.A., Singh, D., Carothers, K., Fischetti, V.A., Flores-Mireles, A.L., et al. (2020) The M Protein of Streptococcus pyogenes Strain AP53 Retains Cell Surface Functional Plasminogen Binding after Inactivation of the Sortase a Gene. JournalofBacteriology, 202, e00096-20. https://doi.org/10.1128/jb.00096-20
[6]
Tsoi, S.K., Smeesters, P.R., Frost, H.R.C., Licciardi, P. and Steer, A.C. (2015) Correlates of Protection for M Protein-Based Vaccines against Group a Streptococcus. JournalofImmunologyResearch, 2015, Article ID: 167089. https://doi.org/10.1155/2015/167089
[7]
Guzmán, C.A., Talay, S.R., Molinari, G., Medina, E. and Chhatwal, G.S. (1999) Protective Immune Response AGAINST Streptococcus pyogenes in Mice after Intranasal Vaccination with the Fibronectin‐binding Protein SFBI. TheJournalofInfectiousDiseases, 179, 901-906. https://doi.org/10.1086/314655
[8]
Ndiaye, M. (2023) Knowledge, Attitudes and Practices of Pediatric Health Providers in the Dakar Region on Antimicrobial Resistance. Journal of Epidemiology and Public Health, 71, S3.
[9]
Tapia, M.D., Sow, S.O., Tamboura, B., Keita, M.M., Berthe, A., Samake, M., et al. (2015) Streptococcal Pharyngitis in Schoolchildren in Bamako, Mali. PediatricInfectiousDiseaseJournal, 34, 463-468. https://doi.org/10.1097/inf.0000000000000608
[10]
Barsenga, S., Mitiku, H., Tesfa, T. and Shume, T. (2022) Throat Carriage Rate, Associated Factors, and Antimicrobial Susceptibility Pattern of Group A Streptococcus among Healthy Schoolchildren in Jigjiga City, Eastern Ethiopia. BMC Pediatrics, 22, Article No. 227. https://doi.org/10.1186/s12887-022-03294-2
[11]
Sanjeeb, S. (2025) Prevalence of Streptococcus pyogenes Infection in Children Aged between 5 to 15 Years with Acute Tonsillopharyngitis and Its Antibiogram. IOSR Journal of Dental and Medical Sciences, 13, 50-55. https://www.researchgate.net/publication/284453875
[12]
Coulibaly, M.B. (2012) Epidemiological-Clinical Study of Dermatoses Observed in Children. https://www.bibliosante.ml/handle/123456789/1524
[13]
Téclessou, J.N., Dovi-Tevi, K.A., Kombaté, K., Saka, B., Akakpo, A.S. and Pitché, P. (2022) Distribution of Dermatoses Encountered in Children Seen in Dermatological Consultations in Lomé (Togo). Médecine tropicale et santé internationale, 2, No. 2.
[14]
Nardi, N.M. and Schaefer, T.J. (2023) Impetigo. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK430974/
[15]
Phakade, R., Nataraj, G., Kuyare, S., Khopkar, U. and Mehta, P. (2012) Is Methicillin-Resistant Staphylococcus aureus Involved in Community Acquired Skin and Soft Tissue Infections? JournalofPostgraduateMedicine, 58, 3-7. https://doi.org/10.4103/0022-3859.93245
[16]
Camara, M., Dieng, A. and Boye, C.S.B. (2013) Antibiotic Susceptibility of Streptococcus pyogenes Isolated from Respiratory Tract Infections in Dakar, Senegal. MicrobiologyInsights, 6, 71-75. https://doi.org/10.4137/mbi.s12996
[17]
Lusta, M., Voronkova, O., Chornyi, V., Yesaulenko, I., Shyrokykh, Y., Falko, O., et al. (2025) Sensitivity Profile to Antibacterial Drugs of Streptococcus pyogenes Isolated from Patients with Infections of Various Biotopes. RegulatoryMechanismsinBiosystems, 16, e25052. https://doi.org/10.15421/0225052
[18]
Gashaw, Y., Getaneh, A., Kasew, D., Tigabie, M. and Gelaw, B. (2025) Streptococcus pyogenes Carriage Rate, Associated Factors and Antimicrobial Susceptibility Profiles among Urban and Rural Schoolchildren at Gondar City, Northwest Ethiopia. ScientificReports, 15, Article No. 2507. https://doi.org/10.1038/s41598-024-82009-2
[19]
Ünübol, N., Caglayan, N., Cebeci, S., Beşli, Y., Sancak, B., Uyar, N.Y., et al. (2025) Antimicrobial Resistance and Epidemiological Patterns of Streptococcus pyogenes in Türkiye. JournalofInfectionandPublicHealth, 18, Article ID: 102633. https://doi.org/10.1016/j.jiph.2024.102633
[20]
Beyala, F., Baane, M.P., Guewo-Fokeng, M., Kamga, H.G., Ze, E.A. and Adiogo, D.D. (2021) Evolution of Antibiotic Resistance of Streptococcus pneumoniae in the City of Yaoundé. Health Sciences and Disease, 22, 51-56. https://www.hsd-fmsb.org/index.php/hsd/article/view/2474
[21]
Imöhl, M. and van der Linden, M. (2015) Antimicrobial Susceptibility of Invasive Streptococcus pyogenes Isolates in Germany during 2003-2013. PLOSONE, 10, e0137313. https://doi.org/10.1371/journal.pone.0137313
[22]
Gebre, A.B., Fenta, D.A., Negash, A.A. and Hayile, B.J. (2024) Prevalence, Antibiotic Susceptibility Pattern and Associated Factors of Streptococcus pyogenes among Pediatric Patients with Acute Pharyngitis in Sidama, Southern Ethiopia. InternationalJournalofMicrobiology, 2024, Article ID: 9282571. https://doi.org/10.1155/2024/9282571
[23]
Raghunath, P. and Sadanand, L.N.R. (2021) Prevalence and Antibiotic Susceptibility of Streptococcus pyogenes Isolated from Pyoderma in a Tertiary Care Hospital, Hyderabad, South India. IndianJournalofMicrobiologyResearch, 8, 274-278. https://doi.org/10.18231/j.ijmr.2021.056
