Evaluation of Acetaminophen Tramadol, Tefenol^？ Tablets in Acute Pain Real Life Study

Pain is an unpleasant sensory and emotional experience associated with or similar to that associated with actual or potential tissue damage. Acute pain is a short-term physiological response to an adverse stimulus, associated with surgery, trauma or acute illness. The best intervention strategy is the one that achieves greater well-being with minimal adverse effects. The combined use of analgesics with different mechanisms of action achieves better analgesic efficacy with less toxicity. Objective: To evaluate the efficacy and tolerability of the combination Acetaminophen-Tramadol produced by LETI Laboratories, in the relief of acute pain of different etiology, in real-life conditions. Materials and methods: It was a prospective, observational, multicenter study, which included patients with acute pain of any etiology, or exacerbation of chronic pain, in whom the physician considered that the product was indicated for the short-term relief of that pain. Patients were instructed to take 1 tablet of Tramadol 37.5 mg and acetaminophen 325 mg (Tefenol？ Tablets), orally, every 8 hours, at the same time of the day and to note the time of daily intake. Pain was assessed using a visual analogue scale (VAS) and pain relief was assessed using the PAIN RELIEF scale at times 0, 1, 2, 3, 4 and 5 days, every 24 hours, just before the first dose of the day. Results: There was a significant decrease in the VAS between each period analyzed until day 5 of treatment. The sums of the differences in Pain Intensity increased significantly at each of the assessment times. The sum of pain intensity relief increased significantly at each of the assessment times. Significant pain relief was observed on both scales in each evaluation period, indicating a progressive and constant effect throughout the evaluation period. Conclusions: Tramadol 37.5 mg and acetaminophen 325 mg (Tefenol？ Tablets) is a useful association for the adequate management of acute pain and pain exacerbation in patients with chronic pain, with good tolerance.