Introduction: In sub-Saharan Africa, allergic diseases are increasing, but their management remains limited due to a lack of specialized centers, appropriate diagnostic tools, and local epidemiological data. To address these challenges, an immunology-allergology unit was established at Cocody University Hospital in Abidjan. Objective: To describe the clinical, immunological, and environmental characteristics of patients consulting for suspected allergy over a ten-year period. Methods: A retrospective, descriptive, and analytical study was conducted using 350 patient records from the allergology outpatient clinic between January 2015 and December 2024. Sociodemographic, clinical, and environmental data, along with results from skin, biological, and functional allergy tests, were analyzed using Epi Info version 7.2.4. A p-value < 0.05 was considered statistically significant. Results: Cutaneous symptoms were the most common (46.3%), followed by respiratory manifestations (33.1%). An atopic background was identified in 92.6% of patients. Skin prick tests, performed in 85.3% of cases, revealed polysensitization in 67.1%, mainly to aeroallergens (44.6%) such as Blomia tropicalis and Glycyphagusdomesticus, and to food allergens (16.9%) such as peanut, egg, and crab. Biological (total/specific IgE, eosinophils) and functional (spirometry, provocation tests) assessments were infrequently available. Allergen avoidance, antihistamines, and corticosteroids were the most prescribed treatments. Allergen immunotherapy was initiated in 5.1% of cases. Conclusion: This ten-year review highlights the predominance of perennial tropical allergens and the high rate of polysensitization in an urban context. It underscores the need to improve access to specialized allergy diagnostics and to strengthen local capacities in allergology.
References
[1]
Pawankar, R. (2014) Allergic Diseases and Asthma: A Global Public Health Concern and a Call to Action. WorldAllergyOrganizationJournal, 7, Article 12. https://doi.org/10.1186/1939-4551-7-12
[2]
Bousquet, J., Schünemann, H.J., Samolinski, B., Demoly, P., Baena-Cagnani, C.E., Bachert, C., et al. (2012) Allergic Rhinitis and Its Impact on Asthma (ARIA): Achievements in 10 Years and Future Needs. JournalofAllergyandClinicalImmunology, 130, 1049-1062. https://doi.org/10.1016/j.jaci.2012.07.053
[3]
Tapsoba, P.G., Ouédraogo, N.A., Ndiaye, M., Ouédraogo, M.S., Traoré, F., Bognini, D.J., et al. (2017) Profil allergénique des patients symptomatiques réalisant des prick-tests dans une structure sanitaire privée de la ville de Ouagadougou (Burkina Faso). Science et Technique, Série Sciences de la Santé, 40, 9-17.
[4]
Agodokpessi, G., Sagbo, G., Bigot, C., Hountohotegbe, T., Dossou-Yovo, S., Djogbessi, D., et al. (2019) Sensibilisation aux acariens chez les enfants suivis pour allergie respiratoire en milieu tropical africain à Cotonou, Bénin. RevuedesMaladiesRespiratoires, 36, 135-141. https://doi.org/10.1016/j.rmr.2018.01.016
[5]
Dasse, S., Siransy, L., Yeboah, R., Adou, H., Koffi, N., Kouakou, P., et al. (2016) État de sensibilisation aux allergènes aéroportés chez le drépanocytaire à Abidjan—Côte d’Ivoire. Revue Française d’Allergologie, 56, 283. https://doi.org/10.1016/j.reval.2016.02.054
[6]
Adou, A.H., Siransy, L., Kouacou, A.P., Yeboah, R., N’guessan, K. and Dassé, S.R. (2017) Évaluation des mesures d’éviction des acariens dans la rhinite allergique au CHU de Cocody, Abidjan. RevueFrançaised’Allergologie, 57, 244-245. https://doi.org/10.1016/j.reval.2017.02.089
[7]
Dasse, S.R., Adou, A.H., Siransy, K.L., Kouacou, A.P.V. and Yeboah, O.R. (2019) Sensibilisation aux acariens: Fréquence et allergènes croisants avec les crustacés chez le sujet suivi en consultation d’allergologie en Côte d’Ivoire. RevueFrançaised’Allergologie, 59, 254. https://doi.org/10.1016/j.reval.2019.02.049
[8]
Dassé, S.R., Kouacou, A.P.V., Adou, A.H., Yeboah, O.R., Assi, A.U.A., Siransy, K.L., et al. (2024) État de sensibilisation allergénique aux protéines de lait de vache chez les enfants de 0 à 3 ans suivis au service de Pédiatrie du CHU de Cocody-Abidjan (Côte d’Ivoire). RevueFrançaised’Allergologie, 64, Article ID: 103829. https://doi.org/10.1016/j.reval.2024.103829
[9]
Adou, A.H., Siransy, L., Yeboah, R., Kouacou, A.P., N’Guessan, K. and Dassé, R. (2017) État de sensibilisation allergénique au café et au thé chez le drépanocytaire atopique. RevueFrançaised’Allergologie, 57, 356-363. https://doi.org/10.1016/j.reval.2017.02.148
[10]
Dassé, S.R., Adou, A.H., Siransy, K.L., Yeboah, O.R., Kouacou, A.P.V., Assi, A.U.A., et al. (2024) Fréquence de la sensibilisation aux anesthésiques: Intérêt de l’enquête allergologique dans les consultations pré anesthésiques en Côte d’Ivoire. RevueFrançaised’Allergologie, 64, Article ID: 103969. https://doi.org/10.1016/j.reval.2024.103969
[11]
Bousquet, J., Heinzerling, L., Bachert, C., Papadopoulos, N.G., Bousquet, P.J., Burney, P.G., et al. (2012) Practical Guide to Skin Prick Tests in Allergy to Aeroallergens. Allergy, 67, 18-24.
[12]
Kristiansen, M., Dhami, S., Netuveli, G., Halken, S., Muraro, A., Roberts, G., et al. (2016) Allergen Immunotherapy for the Prevention of Allergy: A Systematic Review and Meta-Analysis. PediatricAllergyandImmunology, 28, 18-29. https://doi.org/10.1111/pai.12661
[13]
Hon, K.L., Chu, S. and Leung, A.K.C. (2022) Quality of Life for Children with Allergic Skin Diseases. CurrentPediatricReviews, 18, 191-196. https://doi.org/10.2174/1573396317666210901124211
[14]
Mvoundza Ndjindji, O., Minto’o Rogombe, S., Mougola Bissiengou, P., Mveang-Nzoghe, A., Leboueny, M., Mbina, O., et al. (2023) Allergen Sensitization and Polysensitization Pattern of Adults and Children in an Urban Sub-Saharan African Setting (Libreville, Gabon). JournalofAllergyandClinicalImmunology: Global, 2, 23-29. https://doi.org/10.1016/j.jacig.2022.10.005
[15]
Mvoundza Ndjindji, O. and Djoba Siawaya, J.F. (2022) Mapping Allergic Diseases in Sub-Saharan Africa. FrontiersinAllergy, 3, Article 850291. https://doi.org/10.3389/falgy.2022.850291
[16]
DeVries, A. and Vercelli, D. (2015) Epigenetics in Allergic Diseases. CurrentOpinioninPediatrics, 27, 719-723. https://doi.org/10.1097/mop.0000000000000285
[17]
Genuneit, J. and Standl, M. (2021) Epidemiology of Allergy: Natural Course and Risk Factors of Allergic Diseases. In: Traidl-Hoffmann, C., Zuberbier, T. and Werfel, T., Eds., Allergic Diseases—From Basic Mechanisms to Comprehensive Management and Prevention, Springer, 21-27. https://doi.org/10.1007/164_2021_507
[18]
Vassilopoulou, E., Skypala, I., Feketea, G., Gawlik, R., Dunn Galvin, A., Meyer, R., et al. (2021) A Multi‐Disciplinary Approach to the Diagnosis and Management of Allergic Diseases: An EAACI Task Force. PediatricAllergyandImmunology, 33, e13692. https://doi.org/10.1111/pai.13692
[19]
Hossny, E., El-Sayed, S. and Abdul-Rahman, N. (2014) Sensitivity to Five Types of House Dust Mite in a Group of Allergic Egyptian Children. PediatricAllergy, Immunology, andPulmonology, 27, 133-137. https://doi.org/10.1089/ped.2014.0333
[20]
Ade, S. (2019) Cutaneous Sensitizations and Allergies to House Dust Mites among Adults Patients with Rhinitis or Asthma Followed at Parakou in the North of Benin. JournalofFunctionalVentilationandPulmonology, 10, 26-31. https://doi.org/10.12699/jfvpulm.10.31.2019.26
Lu, M.Y., Shobnam, N., Livinski, A.A., Saksena, S., Salters, D., Biete, M., et al. (2024) Examining Allergy Related Diseases in Africa: A Scoping Review Protocol. PLOSONE, 19, e0297949. https://doi.org/10.1371/journal.pone.0297949
[23]
Halken, S., Larenas‐Linnemann, D., Roberts, G., Calderón, M.A., Angier, E., Pfaar, O., et al. (2017) EAACI Guidelines on Allergen Immunotherapy: Prevention of Allergy. PediatricAllergyandImmunology, 28, 728-745. https://doi.org/10.1111/pai.12807
[24]
Ring, J., Beyer, K., Biedermann, T., Bircher, A., Fischer, M., Fuchs, T., et al. (2021) Messages for Patients and Relatives from the 2021 Update of the Guideline on Acute Therapy and Management of Anaphylaxis. AllergoJournalInternational, 30, 243-248. https://doi.org/10.1007/s40629-021-00185-3
[25]
Dassé, S.R., Siransy, K.L., N’Guessan, K., Adou, A.H., Yeboah, O.R., Assi, A.U.A., et al. (2023) Évaluation de l’efficacité de l’Omalizumab dans l’asthme persistant sévère non contrôlé d’origine allergique en contexte de polysensibilisation allergénique. Revue Algérienned’Immunologie et d’Allergologie, 8, 9-17.
[26]
Dinardo, G., Chiera, F., Arasi, S., Giannetti, A., Caimmi, D., Mastrorilli, C., et al. (2025) Allergy Skin Tests: An Update on Skin Prick Test and Prick to Prick. ItalianJournalofPediatricAllergyandImmunology, 39, 26-34. https://doi.org/10.53151/2531-3916/2025-1109
[27]
Muraro, A., Worm, M., Alviani, C., Cardona, V., DunnGalvin, A., Garvey, L.H., et al. (2021) EAACI guidelines: Anaphylaxis (2021 Update). Allergy, 77, 357-377. https://doi.org/10.1111/all.15032
[28]
Santos, A.F., Riggioni, C., Agache, I., Akdis, C.A., Akdis, M., Alvarez‐Perea, A., et al. (2023) EAACI Guidelines on the Diagnosis of IgE-Mediated Food Allergy. Allergy, 78, 3057-3076. https://doi.org/10.1111/all.15902
[29]
Association Nationale de Formation Continue en Allergologie (ANAFORCAL) and Fédération ANAFORCAL Internationale (2021) Allergologie Pratique. https://www.abeforcal.org/wp-content/uploads/2021/06/AP137DEF.pdf
[30]
Stróżek, J., Samoliński, B., Kłak, A., Gawińska-Drużba, E., Izdebski, R., Krzych-Fałta, E., et al. (2019) The Indirect Costs of Allergic Diseases. InternationalJournalofOccupationalMedicineandEnvironmentalHealth, 32, 281-290. https://doi.org/10.13075/ijomeh.1896.01275
[31]
Licona-Limón, P., Kim, L.K., Palm, N.W. and Flavell, R.A. (2013) TH2, Allergy and Group 2 Innate Lymphoid Cells. NatureImmunology, 14, 536-542. https://doi.org/10.1038/ni.2617
[32]
Ogulur, I., Mitamura, Y., Yazici, D., Pat, Y., Ardicli, S., Li, M., et al. (2025) Type 2 Immunity in Allergic Diseases. Cellular&MolecularImmunology, 22, 211-242. https://doi.org/10.1038/s41423-025-01261-2
[33]
Palomares, O. (2013) The Role of Regulatory T Cells in IgE-Mediated Food Allergy. Journal of Investigational Allergology and Clinical Immunology, 23, 371-382.
[34]
Dzidic, M., Boix-Amorós, A., Selma-Royo, M., Mira, A. and Collado, M.C. (2018) Gut Microbiota and Mucosal Immunity in the Neonate. MedicalSciences, 6, Article 56. https://doi.org/10.3390/medsci6030056
[35]
Pascal, M., Perez-Gordo, M., Caballero, T., Escribese, M.M., Lopez Longo, M.N., Luengo, O., et al. (2018) Microbiome and Allergic Diseases. FrontiersinImmunology, 9, Article 1584. https://doi.org/10.3389/fimmu.2018.01584
[36]
Losol, P., Sokolowska, M., Hwang, Y., Ogulur, I., Mitamura, Y., Yazici, D., et al. (2023) Epithelial Barrier Theory: The Role of Exposome, Microbiome, and Barrier Function in Allergic Diseases. Allergy, Asthma & Immunology Research, 15, 705-724. https://doi.org/10.4168/aair.2023.15.6.705
