Efficacy of Mixture of Osteon II Collagen with Hyaluronic Acid for Immediate Implant Placement in Chronic Infected Socket (Clinical and Radiographic Study)
Objective: This randomized controlled trial (RCT) was conducted to compare the effectiveness of Osteon II collagen with hyaluronic acid versus Osteon II collagen alone for immediate implant placement in infected sockets. Patients and Methods: This study was conducted on 20 patients at the Department of Oral and Maxillofacial Surgery at Al-Azhar University’s Assiut Branch and they were divided into; Group Ι (control): 10 patients who received immediate dental implants with Osteon II collagen graft only and Group II: 10 patients who received immediate dental implants with Osteon II collagen with Hyaluronic acid graft. Results: Regarding Modified Bleeding Index (MBI), there was no statistically significant difference between 6 months and 9 months in Group I, while there was a statistically significant difference in Group II. There was no statistically significant difference at 6 months and 9 months between Group I and Group II. Regarding marginal bone loss (MBL), in Group I, there was a statistically significant difference between baseline, 3 months and 6 months. In Group II, there was a statistically significant difference between baseline, 3 months and 6 months. There was no statistically significant difference at baseline and 3 months between Group I and Group II. There was a statistically significant difference at 6 months between Group I and Group II. Conclusion: Adding hyaluronic acid to Osteon II Collagen contributes to increased bone density, improved implant stability, a reduction in MBL, and a shorter healing time.
References
[1]
Huwais, S., Mazor, Z., Ioannou, A., Gluckman, H. and Neiva, R. (2018) A Multicenter Retrospective Clinical Study with Up-To-5-Year Follow-Up Utilizing a Method That Enhances Bone Density and Allows for Transcrestal Sinus Augmentation through Compaction Grafting. The International Journal of Oral & Maxillofacial Implants, 33, 1305-1311. https://doi.org/10.11607/jomi.6770
[2]
Ortega-Martinez, J., Perez-Pascual, T., Mareque-Bueno, S., Hernandez-Alfaro, F. and Ferres-Padro, E. (2012) Immediate Implants Following Tooth Extraction. a Systematic Review. Medicina Oral Patología Oral y Cirugia Bucal, 17, e251-e261. https://doi.org/10.4317/medoral.17469
[3]
Blus, C., Szmukler‐Moncler, S., Khoury, P. and Orrù, G. (2013) Immediate Implants Placed in Infected and Noninfected Sites after Atraumatic Tooth Extraction and Placement with Ultrasonic Bone Surgery. Clinical Implant Dentistry and Related Research, 17, e287-e297. https://doi.org/10.1111/cid.12126
[4]
Muhamad, A., Azzaldeen, A., Aspasia, S. and Nikos, K. (2013) Implants into Fresh Extraction Site: A Literature Review, Case Immediate Placement Report. Journal of Dental Implants, 3, 160-164. https://doi.org/10.4103/0974-6781.118858
[5]
Reynolds, M.A., Aichelmann‐Reidy, M.E., Branch‐Mays, G.L. and Gunsolley, J.C. (2003) The Efficacy of Bone Replacement Grafts in the Treatment of Periodontal Osseous Defects. a Systematic Review. Annals of Periodontology, 8, 227-265. https://doi.org/10.1902/annals.2003.8.1.227
[6]
Keating, J.F. and McQueen, M.M. (2001) Substitutes for Autologous Bone Graft in Orthopaedic Trauma. The Journal of Bone and Joint Surgery. British Volume, 83, 3-8. https://doi.org/10.1302/0301-620x.83b1.0830003
[7]
Kim, Y., Yun, P., Lim, S., Kim, S., Lee, H. and Ong, J.L. (2007) Clinical Evaluations of OSTEON® as a New Alloplastic Material in Sinus Bone Grafting and Its Effect on Bone Healing. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 86, 270-277. https://doi.org/10.1002/jbm.b.31015
[8]
Aguado, E., Pascaretti-Grizon, F., Gaudin-Audrain, C., Goyenvalle, E. and Chappard, D. (2013) β-TCP Granules Mixed with Reticulated Hyaluronic Acid Induce an Increase in Bone Apposition. Biomedical Materials, 9, Article ID: 015001. https://doi.org/10.1088/1748-6041/9/1/015001
[9]
Schropp, L., Wenzel, A., Kostopoulos, L. and Karring, T. (2003) Bone Healing and Soft Tissue Contour Changes Following Single-Tooth Extraction: A Clinical and Radiographic 12-Month Prospective Study. International Journal of Periodontics & Restorative Dentistry, 23, 313-323.
[10]
Robert, L. (2015) Hyaluronan, a Truly “Youthful” Polysaccharide. Its Medical Applications. Pathologie Biologie, 63, 32-34. https://doi.org/10.1016/j.patbio.2014.05.019
[11]
Tammi, R.H., Kultti, A., Kosma, V., Pirinen, R., Auvinen, P. and Tammi, M.I. (2008) Hyaluronan in Human Tumors: Pathobiological and Prognostic Messages from Cell-Associated and Stromal Hyaluronan. Seminars in Cancer Biology, 18, 288-295. https://doi.org/10.1016/j.semcancer.2008.03.005
[12]
Abramson, J.H. (1966) The Cornell Medical Index as an Epidemiological Tool. American Journal of Public Health and the Nations Health, 56, 287-298. https://doi.org/10.2105/ajph.56.2.287
[13]
Taman, R.A., Fahmy, M.H., Karam, S.S. and EL Ashwah, A.A. (2017) Post-Extraction Socket Preservation with Autogenous Bone Graft and Hyaluronic Acid Followed by Delayed Implant Placement. Alexandria Dental Journal, 42, 170-176. https://doi.org/10.21608/adjalexu.2017.57922
[14]
Baiomy, A.A. (2019) Effect of Osteon II Collagen with Hyaluronic Acid on Osseointegration of Simultaneous Placed Implant in Piezoelectric Splitted Posterior Mandibular Alveolar Ridge (Clinical and Radiographic Study). Egyptian Dental Journal, 65, 103-112. https://doi.org/10.21608/edj.2015.71253
[15]
Said, H. (2021) Post Extraction Immediate Implant Placement in Infected Extraction Sockets of Maxillary Posterior Teeth Combined with Guided Bone Regeneration. Two-Years Prospective Clinical and Radiographic Outcomes. Egyptian Journal of Oral and Maxillofacial Surgery, 12, 128-136. https://doi.org/10.21608/omx.2021.93989.1135
[16]
Elsyad, M.A. and Khirallah, A.S. (2016) Circumferential Bone Loss around Splinted and Nonsplinted Immediately Loaded Implants Retaining Mandibular Overdentures: A Randomized Controlled Clinical Trial Using Cone Beam Computed Tomography. The Journal of Prosthetic Dentistry, 116, 741-748. https://doi.org/10.1016/j.prosdent.2016.03.005
[17]
Dimitriou, R., Mataliotakis, G.I., Calori, G.M. and Giannoudis, P.V. (2012) The Role of Barrier Membranes for Guided Bone Regeneration and Restoration of Large Bone Defects: Current Experimental and Clinical Evidence. BMC Medicine, 10, Article No. 81. https://doi.org/10.1186/1741-7015-10-81
[18]
Strbac, G.D., Unger, E., Donner, R., Bijak, M., Watzek, G. and Zechner, W. (2012) Thermal Effects of a Combined Irrigation Method during Implant Site Drilling. A Standardized in Vitro Study Using a Bovine Rib Model. Clinical Oral Implants Research, 25, 665-674. https://doi.org/10.1111/clr.12032
[19]
De Araújo Nobre, M., Cintra, N. and Maló, P. (2007) Peri-Implant Maintenance of Immediate Function Implants: A Pilot Study Comparing Hyaluronic Acid and Chlorhexidine. International Journal of Dental Hygiene, 5, 87-94. https://doi.org/10.1111/j.1601-5037.2007.00239.x
[20]
Vanden Bogaerde, L. (2009) Treatment of Infrabony Periodontal Defects with Esterified Hyaluronic Acid: Clinical Report of 19 Consecutive Lesions. International Journal of Periodontics & Restorative Dentistry, 29, 315-323.
[21]
Roos, J., Sennerby, L., Lekholm, U., Jemt, T., Gröndahl, K. and Albrektsson, T. (1997) A Qualitative and Quantitative Method for Evaluating Implant Success: A 5-Year Retrospective Analysis of the Brånemark Implant. The International Journal of Oral & Maxillofacial Implants, 12, 504-514.
[22]
Hohlweg-Majert, B., Metzger, M.C., Kummer, T. and Schulze, D. (2011) Morphometric Analysis—Cone Beam Computed Tomography to Predict Bone Quality and Quantity. Journal of Cranio-Maxillofacial Surgery, 39, 330-334. https://doi.org/10.1016/j.jcms.2010.10.002
[23]
Truninger, T.C., Philipp, A.O.H., Siegenthaler, D.W., Roos, M., Hämmerle, C.H.F. and Jung, R.E. (2010) A Prospective, Controlled Clinical Trial Evaluating the Clinical and Radiological Outcome after 3 Years of Immediately Placed Implants in Sockets Exhibiting Periapical Pathology. Clinical Oral Implants Research, 22, 20-27. https://doi.org/10.1111/j.1600-0501.2010.01973.x
[24]
Kim, J., Song, H.Y., Ben Amara, H., Kyung‐Rim, K. and Koo, K. (2016) Hyaluronic Acid Improves Bone Formation in Extraction Sockets with Chronic Pathology: A Pilot Study in Dogs. Journal of Periodontology, 87, 790-795. https://doi.org/10.1902/jop.2016.150707
[25]
Aslan, M., Şimşek, G. and Dayi, E. (2006) The Effect of Hyaluronic Acid-Supplemented Bone Graft in Bone Healing: Experimental Study in Rabbits. Journal of Biomaterials Applications, 20, 209-220. https://doi.org/10.1177/0885328206051047
[26]
Albrektsson, T., Zarb, G., Worthington, P. and Eriksson, A.R. (1986) The Long-Term Efficacy of Currently Used Dental Implants: A Review and Proposed Criteria of Success. The International Journal of Oral & Maxillofacial Implants, 1, 11-25.