Atheromatous disease can cause a heart attack or stroke in humans. This present research aims to investigate the comparison between Newtonian and rheological models in terms of hemodynamic risk factors. A three-dimensional computational model has been considered here for 45%, 60%, and 75% stenoses. The COMSOL Multiphysics software has been used in fluid flow simulation to solve the governing equations. The comparison between Newtonian and non-Newtonian has been performed to predict the model’s suitability. Hemodynamic parameters such as time-averaged wall shear stress (TAWSS), oscillatory shearing index, and blood residence time show a lower disturbed flow regime for non-Newtonian fluid compared to Newtonian fluid. The TAWSS for 75% stenosis is increased by 54.84% and 37.18% to those of 45% and 60% stenoses. A suitable non-Newtonian model can be used in bioengineering fields.
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