全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

Diabetic Peripheral Neuropathies in Type 2 Diabetes at Brazzaville University Hospital: Prevalence and Associated Factors

DOI: 10.4236/wjns.2025.153017, PP. 208-221

Keywords: Type 2 Diabetes, Diabetic Peripheral Neuropathy, Prevalence, Associated Factors, Brazzaville, Sub-Saharan Africa

Full-Text   Cite this paper   Add to My Lib

Abstract:

Introduction: Diabetic peripheral neuropathy (DPN) is a frequent and disabling complication of type 2 diabetes mellitus (T2DM), often underdiagnosed. This study aimed to determine the prevalence of DPN and identified its associated factors among T2DM patients in Brazzaville. Methods: A descriptive and analytical cross-sectional study was conducted from February to July 2024 among T2DM patients at the Brazzaville University Hospital. Patients aged 18 and older, who underwent neurological and electroneuromyographic (ENMG) assessment, were included. Multivariate logistic regression was used to identify factors associated with DPN. Results: Of 102 patients included, 81 (79.4%) were diagnosed with DPN. Carpal tunnel syndrome (87%) and distal sensorimotor polyneuropathy (37%) were the most frequent presentations. ENMG revealed 18.5% of subclinical cases. The mean age of patients with DPN was 59.75 ± 9.87 years. Advanced age (OR = 1.069; p = 0.027) and longer duration of diabetes (OR = 1.034; p = 0.034) were significantly associated with DPN. Conclusion: DPN is highly prevalent among T2DM patients in Brazzaville. Routine ENMG at diagnosis is recommended to facilitate early detection and limits complications.

References

[1]  IDF (2024) Facts and Figures. International Diabetes Federation (IDF).
https://idf.org/about-diabetes/diabetes-facts-figures/
[2]  Schaper, N.C., Apelqvist, J. and Bakker, K. (2003) The International Consensus and Practical Guidelines on the Management and Prevention of the Diabetic Foot. Current Diabetes Reports, 3, 475-479.
https://doi.org/10.1007/s11892-003-0010-4
[3]  Lu, X., Xie, Q., Pan, X., Zhang, R., Zhang, X., Peng, G., et al. (2024) Type 2 Diabetes Mellitus in Adults: Pathogenesis, Prevention and Therapy. Signal Transduction and Targeted Therapy, 9, Article No. 262.
https://doi.org/10.1038/s41392-024-01951-9
[4]  Feldman, E.L., Callaghan, B.C., Pop-Busui, R., Zochodne, D.W., Wright, D.E., Bennett, D.L., et al. (2019) Diabetic Neuropathy. Nature Reviews Disease Primers, 5, Article No. 41.
https://doi.org/10.1038/s41572-019-0092-1
[5]  Hode, A.K., Dedjan, H. and Sondjo, F.M. (2023) Peripheral Neuropathy and Associated Factors in Diabetics at the CNHU-HKM of Cotonou in 2021. Journal of Diabetes Mellitus, 13, 12-22.
https://doi.org/10.4236/jdm.2023.131002
[6]  Munyambalu, D.K., Hildago, I., Bafwa, Y.T., Lagoro, C.A., Sikakulya, F.K., Vahwere, B.M., et al. (2023) Prevalence and Grade of Diabetic Peripheral Neuropathy among Known Diabetic Patients in Rural Uganda. Frontiers in Clinical Diabetes and Healthcare, 3, Article ID: 1001872.
https://doi.org/10.3389/fcdhc.2022.1001872
[7]  Tesfaye, S., Boulton, A.J.M., Dyck, P.J., Freeman, R., Horowitz, M., Kempler, P., et al. (2010) Diabetic Neuropathies: Update on Definitions, Diagnostic Criteria, Estimation of Severity, and Treatments. Diabetes Care, 33, 2285-2293.
https://doi.org/10.2337/dc10-1303
[8]  Boulton, A.J.M., Vinik, A.I., Arezzo, J.C., Bril, V., Feldman, E.L., Freeman, R., et al. (2005) Diabetic Neuropathies: A Statement by the American Diabetes Association. Diabetes Care, 28, 956-962.
https://doi.org/10.2337/diacare.28.4.956
[9]  Bilal, A., Amarasena, D.K. and Pillai, A. (2023) Socioeconomic Deprivation as a Predictor of Lower Limb Amputation in Diabetic Foot Disease. Cureus, 15, e44426.
https://doi.org/10.7759/cureus.44426
[10]  Elilie Mawa Ongoth, F., Andzouana Mbamognoua, N.G., Okoumou-Moko, A., Mayanda Ohouana, R.L., Bilongo Bouyou, A.S.W., Dinghat, O.M.Y., et al. (2023) Profil épidémiologique et diagnostique du pied diabétique au centre hospitalier universitaire de Brazzaville. Health Sciences and Diseases, 1, 52-56.
https://hsd-fmsb.org/index.php/hra/article/view/4961/3849
[11]  Van den Bergh, P.Y.K., Hadden, R.D.M., Bouche, P., Cornblath, D.R., Hahn, A., Illa, I., et al. (2010) European Federation of Neurological Societies/Peripheral Nerve Society Guideline on Management of Chronic Inflammatory Demyelinating Polyradiculoneuropathy: Report of a Joint Task Force of the European Federation of Neurological Societies and the Peripheral Nerve Society—First Revision. European Journal of Neurology, 17, 356-363.
https://doi.org/10.1111/j.1468-1331.2009.02930.x
[12]  Mpandzou, G., Bandzouzi, P.S., Diatewa, J., Kane, M., Moutoula-Latou, D., Kaba, Y., et al. (2022) Valeurs de référence des paramètres électroneuromyographiques du laboratoire de neurophysiologique clinique au centre hospitalier universitaire de Brazzaville. Health Sciences and Diseases, 23, 23-27.
https://www.hsd-fmsb.org/index.php/hsd/article/view/3421/2949
[13]  HAS (2007) Prise en charge de l’artériopathie chronique oblitérante athéroscléreuse des membres inférieurs (indications médicamenteuses, de revascularisation et de rééducation): Service des recommandations professionnelles-avril 2006. Annales de Dermatologie et de Vénéréologie, 134, 199-206.
https://doi.org/
https://doi.org/10.1016/S0151-9638(07)91621-X
[14]  Lu, Y., Xing, P., Cai, X., Luo, D., Li, R., Lloyd, C., et al. (2020) Prevalence and Risk Factors for Diabetic Peripheral Neuropathy in Type 2 Diabetic Patients from 14 Countries: Estimates of the INTERPRET-DD Study. Frontiers in Public Health, 8, Article ID: 534372.
https://doi.org/10.3389/fpubh.2020.534372
[15]  Shiferaw, W.S., Akalu, T.Y., Work, Y. and Aynalem, Y.A. (2020) Prevalence of Diabetic Peripheral Neuropathy in Africa: A Systematic Review and Meta-Analysis. BMC Endocrine Disorders, 20, Article No. 49.
https://doi.org/10.1186/s12902-020-0534-5
[16]  Adoukonou, A., Magy, L., Gnonlonfoun, D., Gallouedec, G., Khalil, M. and Vallat, G. (2010) Profil electroneuromyographique des neuropathies dans une population de patients diabetiques admis dans un laboratoire de neurophysiologie. African Journal of Neurological Sciences, 27, 77-85.
https://doi.org/10.4314/ajns.v27i2.55102
[17]  Salha, S., Ghodhbane, Z. and Sghaier, S. (2018) Neuropathie Diabétique du Sujet Âgé: Étude Électro-Clinique. Middle East Journal of Age and Ageing, 15, 67-67.
https://doi.org/10.5742/mejaa.2018.93419
[18]  Mekuria Negussie, Y. and Tilahun Bekele, N. (2024) Diabetic Peripheral Neuropathy among Adult Type 2 Diabetes Patients in Adama, Ethiopia: Health Facility-Based Study. Scientific Reports, 14, Article No. 3844.
https://doi.org/10.1038/s41598-024-53951-y
[19]  Soni, K., Srivastava, D.K., Kumar, S., Bajpai, P.K., Shukla, S.K. and Prakash, S. (2024) Prevalence of Diabetic Peripheral Neuropathy among Type 2 Diabetes Mellitus Patients and Its Associated Risk Factors. Indian Journal of Community Health, 36, 208-214.
https://doi.org/10.47203/ijch.2024.v36i02.009
[20]  Maiga, Y., Diallo, S., Konipo, F.d.N., Sangho, O., Sangaré, M., Diallo, S.H., et al. (2020) Diabetic Polyneuropathy with/out Neuropathic Pain in Mali: A Cross-Sectional Study in Two Reference Diabetes Treatment Centers in Bamako (Mali), Western Africa. PLOS ONE, 15, e0241387.
https://doi.org/10.1371/journal.pone.0241387
[21]  Tesfaye, S., Stevens, L.K., Stephenson, J.M., Fuller, J.H., Plater, M., Ionescu-Tirgoviste, C., et al. (1996) Prevalence of Diabetic Peripheral Neuropathy and Its Relation to Glycaemic Control and Potential Risk Factors: The EURODIAB IDDM Complications Study. Diabetologia, 39, 1377-1384.
https://doi.org/10.1007/s001250050586
[22]  Rekik, S., Kammoun, I., Triki, L., Affes, Z., Jemea, S.B., Zouari, H., et al. (2016) Particularités du syndrome du canal carpien chez les diabétiques: Étude castémoin. Revue Neurologique, 172, A110.
https://doi.org/10.1016/j.neurol.2016.01.263
[23]  Zamfirov, K. (2017) Manifestations musculosquelettiques du diabète sucré: Une complication fréquente. Revue Médicale Suisse, 13, 917-921.
https://doi.org/10.53738/revmed.2017.13.560.0917
[24]  Lahrichi, S., Nassar, K. and Janani, S. (2021) Le syndrome du canal carpien et le diabète. Revue du Rhumatisme, 88, A169.
https://doi.org/10.1016/j.rhum.2021.10.269
[25]  Wei, Y., Xu, S., Wu, Z., Zhang, M., Bao, M. and He, B. (2024) Exploring the Causal Relationships between Type 2 Diabetes and Neurological Disorders Using a Mendelian Randomization Strategy. Medicine, 103, e40412.
https://doi.org/10.1097/md.0000000000040412
[26]  Lebiedz-Odrobina, D. and Kay, J. (2010) Rheumatic Manifestations of Diabetes Mellitus. Rheumatic Disease Clinics of North America, 36, 681-699.
https://doi.org/10.1016/j.rdc.2010.09.008
[27]  Zimmerman, M., Gottsäter, A. and Dahlin, L.B. (2022) Carpal Tunnel Syndrome and Diabetes—A Comprehensive Review. Journal of Clinical Medicine, 11, Article No. 1674.
https://doi.org/10.3390/jcm11061674
[28]  Albers, J.W. and Pop-Busui, R. (2014) Diabetic Neuropathy: Mechanisms, Emerging Treatments, and Subtypes. Current Neurology and Neuroscience Reports, 14, Article No. 473.
https://doi.org/10.1007/s11910-014-0473-5
[29]  Diédhiou, D., Touré, M., Cissé, M., Seck, L.B., Diop, S.N., Guèye, L., et al. (2015) P246 Neuropathie diabétique: Caractéristiques cliniques et électromyographiques au Sénégal. Diabetes & Metabolism, 41, A95.
https://doi.org/10.1016/s1262-3636(15)30359-1
[30]  Dyck, P.J., Albers, J.W., Andersen, H., Arezzo, J.C., Biessels, G., Bril, V., et al. (2011) Diabetic Polyneuropathies: Update on Research Definition, Diagnostic Criteria and Estimation of Severity. Diabetes/Metabolism Research and Reviews, 27, 620-628.
https://doi.org/10.1002/dmrr.1226
[31]  Barbosa, A.P., Medina, J.L., Ramos, E.P. and Barros, H.P. (2001) Prevalence and Risk Factors of Clinical Diabetic Polyneuropathy in a Portuguese Primary Health Care Population. Diabetes & Metabolism, 27, 496-502.
[32]  Jarso, G., Ahmed, A. and Feleke, Y. (2011) The Prevalence, Clinical Features and Management of Periphral Neuropathy among Diabetic Patients in Tikur Anbessa and St. Paul’s Specialized University Hospitals, Addis Ababa, Ethiopia. Ethiopian Medical Journal, 49, 299-311.
[33]  Allen, M.D., Doherty, T.J., Rice, C.L. and Kimpinski, K. (2016) Physiology in Medicine: Neuromuscular Consequences of Diabetic Neuropathy. Journal of Applied Physiology, 121, 1-6.
https://doi.org/10.1152/japplphysiol.00733.2015
[34]  Nukada, H. (2014) Ischemia and Diabetic Neuropathy. In: Handbook of Clinical Neurology, Elsevier, 469-487.
https://doi.org/10.1016/b978-0-444-53480-4.00023-0
[35]  Perez-Matos, M.C., Morales-Alvarez, M.C. and Mendivil, C.O. (2017) Lipids: A Suitable Therapeutic Target in Diabetic Neuropathy? Journal of Diabetes Research, 2017, Article ID: 6943851.
https://doi.org/10.1155/2017/6943851
[36]  Davies, M., Brophy, S., Williams, R. and Taylor, A. (2006) The Prevalence, Severity, and Impact of Painful Diabetic Peripheral Neuropathy in Type 2 Diabetes. Diabetes Care, 29, 1518-1522.
https://doi.org/10.2337/dc05-2228
[37]  Oueslati, I., Ounaissa, K., Smida, A., Chelbi, S., Dag, N.B., Sallami, S., et al. (2018) La neuropathie diabétique périphérique: Prévalence et facteurs prédictifs. Annales d’Endocrinologie, 79, Article No. 491.
https://doi.org/10.1016/j.ando.2018.06.980
[38]  Dyck, P.J.B. and Windebank, A.J. (2002) Diabetic and Nondiabetic Lumbosacral Radiculoplexus Neuropathies: New Insights into Pathophysiology and Treatment. Muscle & Nerve, 25, 477-491.
https://doi.org/10.1002/mus.10080
[39]  Lamini, N., Soundhat, N.E., Nkouala-Kidede, D.C., Moigny-Gajou, Y., Ombou-mahou Bakale, F.E., Salemo, A.P., et al. (2023) Lombalgie commune chez le personnel soignant au CHU de Brazzaville: Aspects épidémiologiques, cliniques et étiologiques. Rhumatologie Africaine Francophone, 6, 17-24.
https://doi.org/10.62455/raf.v6i1.50
[40]  Lamini, N., Soundhat, N.E., Angalla, A.R.L., Moigny-Gajou, Y., Nkouala-Kidede, D.C., Mbouale Ossemba, J.M., et al. (2023) Profil clinique et fonctionnel des patients suivis pour lombalgie commune au CHU de Brazzaville. Rhumatologie Africaine Francophone, 6, 25-31.
https://doi.org/10.62455/raf.v6i1.48
[41]  Pop-Busui, R., Boulton, A.J.M., Feldman, E.L., Bril, V., Freeman, R., Malik, R.A., et al. (2016) Diabetic Neuropathy: A Position Statement by the American Diabetes Association. Diabetes Care, 40, 136-154.
https://doi.org/10.2337/dc16-2042
[42]  Hamdaoui, M.S., Midoun, N. and Belhadj, M. (2023) Facteurs de risque de la neuropathie périphérique patente chez le diabétique de type 2 dans une population algérienne: Principaux déterminants. Médecine des Maladies Métaboliques, 17, 586-593.
https://doi.org/10.1016/j.mmm.2023.08.005
[43]  Levitt Katz, L.E., White, N.H., El ghormli, L., Chan, C.L., Copeland, K.C., Lipman, T.H., et al. (2021) Risk Factors for Diabetic Peripheral Neuropathy in Adolescents and Young Adults with Type 2 Diabetes: Results from the TODAY Study. Diabetes Care, 45, 1065-1072.
https://doi.org/10.2337/dc21-1074
[44]  Liu, X., Xu, Y., An, M. and Zeng, Q. (2019) The Risk Factors for Diabetic Peripheral Neuropathy: A Meta-Analysis. PLOS ONE, 14, e0212574.
https://doi.org/10.1371/journal.pone.0212574
[45]  Young, M.J., Boulton, A.J.M., Macleod, A.F., Williams, D.R.R. and Sonksen, P.H. (1993) A Multicentre Study of the Prevalence of Diabetic Peripheral Neuropathy in the United Kingdom Hospital Clinic Population. Diabetologia, 36, 150-154.
https://doi.org/10.1007/bf00400697
[46]  Poitras, T.M., Munchrath, E. and Zochodne, D.W. (2021) Neurobiological Opportunities in Diabetic Polyneuropathy. Neurotherapeutics, 18, 2303-2323.
https://doi.org/10.1007/s13311-021-01138-y

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133