Introduction: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by polyarticular involvement with predominantly distal, peripheral, bilateral, symmetrical, erosive features and extra-articular manifestations. The objective of this study was to determine the epidemiological, clinical and therapeutic characteristics of patients with rheumatoid arthritis in the Rheumatology Department of the Ignace Deen National Hospital in Conakry. Patients and Methods: This was a descriptive cross-sectional study lasting 18 months from January 1, 2019 to June 18, 2020. Patients with rheumatoid arthritis diagnosed on the basis of clinical and paraclinical arguments in accordance with the ACR/EULAR criteria (2010) were included in this study. Results: We collected 60 cases of RA, representing a hospital prevalence of 5.6%. The mean age of patients was 46.6 ± 17.35 years. Rheumatoid arthritis mainly affected adult women with 78.33%. Symptomatic treatment was dominated by the use of NSAIDs and corticosteroid therapy. MTX was the most used long-term treatment, representing 68.3%, with a therapeutic combination of MTX, HCQ and AIS with 65%. We recorded 23.3% of MTX-related side effects, followed by AIS 11.6% and HCQ 8.3%. After 3 months of treatment, 38.4% of patients had low disease activity and 23.3% were in remission. Conclusion: RA is a serious disease because it can affect the functional prognosis due to its joint consequences and the vital prognosis due to its visceral damage. Methotrexate and other conventional background treatments still have their place.
References
[1]
Sabounji, M.M., Lissimo, H. and Deme, A. (2023) Childhood-Onset Rheumatoid Arthritis at a Tertiary Hospital in Senegal, West Africa. Pediatric Rheumatology, 21, Article No. 98. https://doi.org/10.1186/s12969-023-00889-6
[2]
Lekpa, F.K., Ndongo, S. and Moreira-Diop, T. (2012) Rheumatoid Arthritis in Rural Senegal. European University Publishing.
[3]
Combe, B., Landewe, R., Daien, C.I., Hua, C., Aletaha, D., Álvaro-Gracia, J.M., et al. (2017) 2016 Update of the EULAR Recommendations for the Management of Early Arthritis. Annals of the Rheumatic Diseases, 76, 948-959. https://doi.org/10.1136/annrheumdis-2016-210602
[4]
Mijiyawa, M., Amanga, K., Oniankitan, O.I., Pitché, P. and Tchangaï-Walla, K. (1999) Connective Tissue Diseases in Hospital Consultations in Lomé (Togo). La Revue de Médecine Interne, 20, 13-17. https://doi.org/10.1016/s0248-8663(99)83004-5
[5]
Ouédraogo, A., Kabore, F., Zabsonré/Tiendrebéogo, W.J.S., Nonguierma, V., Savadogo, B., Abassiri, K.A.E., et al. (2024) Rheumatoid Arthritis: Remission without Biotherapy? The Experience of Burkina Faso (West Africa). The Pan African Medical Journal, 47, Article 12. https://doi.org/10.11604/pamj.2024.47.12.37537
[6]
Mijiyawa, M. (1996) Rheumatoid Arthritis in Sub-Saharan Africa. The Journal of Internal Medicine, 17, 625-626.
[7]
Salissou, G.M., Kaba, C., Adamou, G.I., Alassane, S. and Fanata, M. (2019) Rheumatoid Arthritis in Rheumatology Consultation in Maradi, Niger. European Scientific Journal ESJ, 15, 139-149.
[8]
Hua, C. and Combe, B. (2017) The New ACR/EULAR 2010 Classification Criteria for Earlier Diagnosis of Rheumatoid Arthritis. Revue du Rhumatisme Monographies, 84, 337-342. https://doi.org/10.1016/j.monrhu.2017.07.001
[9]
Ouédraogo, D., Ntsiba, H., Tiendrébéogo/Zabsonré, J., Tiéno, H., Bokossa, L.I.F., Kaboré, F., et al. (2014) Clinical Spectrum of Rheumatologic Diseases in a Department of Rheumatology in Ouagadougou (Burkina Faso). Clinical Rheumatology, 33, 385-389. https://doi.org/10.1007/s10067-013-2455-4
[10]
Missounga, L., Ouedraogo, D.D., Nseng Nseng, I.R., Singwe-Ngandeu, M., Daboiko, J.C., Eti, E., et al. (2018) Rheumatology in French-Speaking Black Africa and Madagascar: Status of Rheumatologists, Rheumatological Pathologies, Diagnostic and Therapeutic Means in 2015. Médecine d’Afrique Noire En Ligne, 8, 59-68.
[11]
Hodkinson, B., Tikly, M. and Adebajo, A. (2014) Rheumatoid Arthritis in the Developing World: Stepping up to the Challenge. Clinical Rheumatology, 33, 1195-1196. https://doi.org/10.1007/s10067-014-2690-3
[12]
Diallo, S., Diallo, R., Niasse, M., Diaw, C., Diouf, C., Ndongo, S., et al. (2018) Familial Forms of Rheumatoid Arthritis: A Study of 17 Multiplex Families in Senegal. Rhumatologie Africaine Francophone, 1, 28-35. https://doi.org/10.62455/raf.v1i2.9
[13]
Mousavi, S.E., Nejadghaderi, S.A., Khabbazi, A., Alizadeh, M., Sullman, M.J.M., Kaufman, J.S., et al. (2022) The Burden of Rheumatoid Arthritis in the Middle East and North Africa Region, 1990-2019. Scientific Reports, 12, Article No. 19297. https://doi.org/10.1038/s41598-022-22310-0
[14]
Finckh, A., Gilbert, B., Hodkinson, B., Bae, S., Thomas, R., Deane, K.D., et al. (2022) Global Epidemiology of Rheumatoid Arthritis. Nature Reviews Rheumatology, 18, 591-602. https://doi.org/10.1038/s41584-022-00827-y
[15]
Lala, V., Tikly, M., Musenge, E. and Govind, N. (2022) Comorbidities in Black South Africans with Established Rheumatoid Arthritis. International Journal of Rheumatic Diseases, 25, 699-704. https://doi.org/10.1111/1756-185x.14328
[16]
McInnes, I.B. and Schett, G. (2011) The Pathogenesis of Rheumatoid Arthritis. New England Journal of Medicine, 365, 2205-2219. https://doi.org/10.1056/nejmra1004965
[17]
Kakpovi, K., Koffi-TessioV, H.P., Fianyo, E., Kolou, M. and Kuévikoé, M.I. (2017) Profile of Rheumatoid Arthritis in Rheumatology Consultations in Lomé (Togo). European Scientific Journal, 13, 125-132.
[18]
Essouma, M., Nkeck, J.R., Endomba, F.T., Bigna, J.J. and Ralandison, S. (2020) Epidemiology of Rheumatoid Arthritis in Sub-Saharan Africa: A Systematic Review and Meta-Analysis Protocol. Systematic Reviews, 9, Article No. 81. https://doi.org/10.1186/s13643-020-01342-5
[19]
Niasse, M., Kane, B.S., Ndiaye, A.A., Ndao, A.C., Djiba, B., Fall, S., et al. (2017) Severity of the Rheumatoid Arthritis in Sub-Saharan Africa: Study of 403 Senegalese Observations. Open Journal of Internal Medicine, 7, 151-159. https://doi.org/10.4236/ojim.2017.74016
[20]
Bullock, J., Rizvi, S.A.A., Saleh, A.M., Ahmed, S.S., Do, D.P., Ansari, R.A., et al. (2019) Rheumatoid Arthritis: A Brief Overview of the Treatment. Medical Principles and Practice, 27, 501-507. https://doi.org/10.1159/000493390
[21]
Beck, M. (2015) Costs of Care for Patients with Rheumatoid Arthritis Treated with Biotherapy in 2012 in Alsace: Exploitation of the Medical-Administrative Databases of the Health Insurance. Revue Epidemiology Public Health, 63, 54.
[22]
Gaujoux-Viala, C., Gossec, L., Cantagrel, A., Dougados, M., Fautrel, B., Mariette, X., et al. (2014) Recommendations of the French Society of Rheumatology for the Management of Rheumatoid Arthritis. Revue du Rhumatisme, 81, 303-312. https://doi.org/10.1016/j.rhum.2014.04.009
