Introduction: Myxoma of the floor of the mouth is a rare variety of myxomas of the jaws belonging to the large group of benign tumors of the jaws. Myxoma of the floor of the mouth is a soft tissue myxoma which is opposed to intraosseous myxoma in the maxillofacial sphere. This is a rare tumor whose characteristics are not perfectly defined. We report a case of giant myxoma of the floor of the mouth whose location and size are atypical, posing a diagnostic and therapeutic problem. The aim of this article is to contribute to the knowledge of myxoma by describing the clinical appearance and the therapeutic approach of a giant myxoma of the floor of the mouth. Observation: A 28-year-old patient, a carpenter, residing in a rural area consulted in March 2024 for a large oral mass which had evolved over the past 22 years, causing eating and speaking difficulties. The clinical examination and the maxillofacial scan revealed a large, benign-looking tumor of the floor of the mouth, filling the oral cavity. Tumor excision was performed after intubation by tracheotomy. A histological examination of the surgical specimen revealed a myxoma. The patient also benefited from a dental prosthesis and functional manducative rehabilitation. Postoperative progress was satisfactory after 6 months. Discussion: Giant myxoma of the floor of the mouth is a rare benign tumor whose etiopathogenesis is still controversial. The diagnosis is based on the histological examination of the surgical specimen. Its management requires multidisciplinarity.
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