The objective of our study was to investigate
the association between the Arg16Gly polymorphism in the β2-АR gene and body mass index (BMI) in patients with
bronchial asthma (BA) with regard to the age of onset. Materials and methods: 553 patients were examined. The control group consisted of 95 apparently
healthy individuals. The patients were divided into 2 groups depending on the
age of BA onset: 282 patients with late onset (Group I) and 271 patients with
early onset (Group II). Arg16Gly polymorphism in the β2-АR
gene (rs1042713) was determined using polymerase chain reaction-restriction fragment length
polymorphism analysis. Statistical analysis of obtained results was performed
using SPSS–17 program. Results:There was no significant
difference in the distribution of genotypes for Arg16Gly polymorphism in the β2-AR gene depending on BMI (χ2 = 5.74; р = 0.22), and no
association was found with obesity risks disregarding the age of BA onset. The
study on the frequency of genotypes for this polymorphism with regard to the
age of asthma onset and BMI found statistically significant differences between
early-onset (χ2 = 11.27; p
= 0.02) and
References
[1]
Hallstrand, T.S. (2005) Genetic Pleiotropy between Asthma and Obesity in a Community-Based Sample of Twins. The Journal of Allergy and Clinical Immunology, 116, 1235-1241. https://doi.org/10.1016/j.jaci.2005.09.016
[2]
Salinas, Y.D. and Wang, Z. (2021) Discovery and Mediation Analysis of Cross-Phenotype Associations between Asthma and Body Mass Index in 12q13.2. American Journal of Epidemiology, 190, 85-94. https://doi.org/10.1093/aje/kwaa144
[3]
Contopoulos-Ioannidis, D.G., Manoli, E.N. and Ioannidis, J.P. (2005) Meta-Analysis of the Association of β2-Adrenergic Receptor Polymorphisms with Asthma Phenotypes. The Journal of Allergy and Clinical Immunology, 115, 963-972.
https://doi.org/10.1016/j.jaci.2004.12.1119
[4]
Paiva, A.C., Marson, F.A., Ribeiro, J.D. and Bertuzzo, C.S. (2014) Asthma: Gln27Glu and Arg16Gly Polymorphisms of the β2-Adrenergic Receptor Gene as Risk Factors. Allergy, Asthma & Clinical Immunology, 10, Article No. 8.
https://doi.org/10.1186/1710-1492-10-8
[5]
Angeli, C.B., Kimura, L., Auricchio, M.T., Vicente, J.P. and Mattevi, V.S. (2011) Multilocus Analyses of Seven Candidate Genes Suggest Interacting Pathways for Obesity-Related Traits in Brazilian Populations. Obesity, 19, 1244-1251.
https://doi.org/10.1038/oby.2010.325
[6]
Kawaguchi, H., Masuo, K. and Katsuya, T. (2006) β2-and β3-Adrenoceptor Polymorphisms Relate to Subsequent Weight Gain and Blood Pressure Elevation in Obese Normotensive Individuals. Hypertension Research, 29, 951-959.
https://doi.org/10.1291/hypres.29.951
[7]
Masuo, K., Katsuya, T., Fu, Y., Rakugi, H., Ogihara, T. and Tuck, M.L. (2005) β2-Adrenoceptor Polymorphisms Relate to Insulin Resistance and Sympathetic Overactivity as Early Markers of Metabolic Disease in Nonobese, Normotensive Individuals. American Journal of Hypertension, 18, 1009-1014.
https://doi.org/10.1016/j.amjhyper.2005.01.006
[8]
Liu, Z.Q., Mo, W., Huang, Q. and Zhou, H.H. (2007) Genetic Polymorphism of Human β-Adrenergic Receptor Genes and Their Association with Obesity. Journal of Central South University (Medical Sciences), 32, 359-367.
[9]
Zhu, Z., Hasegawa, К., Camargo, C.A. and Liang, L. (2021) Investigating Asthma Heterogeneity through Shared and Distinct Genetics: Insights from Genome-Wide Cross-Trait Analysis. The Journal of Allergy and Clinical Immunology, 147, 796-807.
https://doi.org/10.1016/j.jaci.2020.07.004
[10]
Ferreira, M., Mathur, R. and Vonk, J.M. (2019) Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct. The American Journal of Human Genetics, 104, 665-684. https://doi.org/10.1016/j.ajhg.2019.02.022
[11]
Melén, E., Himes, B.E., Brehm, J.M., Boutaoui, N., Klanderman, B.J., Sylvia, J.S., et al. (2010) Analyses of Shared Genetic Factors between Asthma and Obesity in Children. The Journal of Allergy and Clinical Immunology, 126, 631-637.
https://doi.org/10.1016/j.jaci.2010.06.030
[12]
Zhang, H., Wu, J. and Yu, L. (2014) Association of Gln27Glu and Arg16Gly Polymorphisms in β2-Adrenergic Receptor Gene with Obesity Susceptibility: A Meta-Analysis. PLoS ONE, 9, e100489. https://doi.org/10.1371/journal.pone.0100489
[13]
Gjesing, A.P., Andersen, G. and Burgdorf, K.S. (2007) Studies of the Associations between Functional β2-Adrenergic Receptor Variants and Obesity, Hypertension and Type 2 Diabetes in 7,808 White subjects. Diabetologia, 50, 563-568.
https://doi.org/10.1007/s00125-006-0578-8
[14]
Large, V., Hellstrom, L., Reynisdottir, S., Lonnqvist, F. and Eriksson, P. (1997) Human β-2 Adrenoceptor Gene Polymorphisms Are Highly Frequent in Obesity and Associate with Altered Adipocyte β-2 Adrenoceptor Function. Journal of Clinical Investigation, 100, 3005-3013. https://doi.org/10.1172/JCI119854
[15]
Jalba, M.S., Rhoads, G.G. and Demissie, K. (2008) Association of Codon 16 and Codon 27 β2-Adrenergic Receptor Gene Polymorphisms with Obesity: A Meta-Analysis. Obesity, 16, 2096-2106. https://doi.org/10.1038/oby.2008.327
