A metabolomic study of the effect of Candida albicans glutamate dehydrogenase deletion on growth and morphogenesis

Three primary metabolic pathways for nitrogen assimilation and glutamate metabolism in C. albicans. Red lines: the reactions catalysed by glutamate dehydrogenases (GDH2 andGDH3). Large arrows indicate reactions that are more favourable, thermodynamically. Black lines: the reactions catalysed by a combination of GLN1 and GLT1, also referred to as GS and GOGAT in S. cerevisiae, respectively. Blue lines: the reactions catalysed by proline utilisation enzymes (PUT1 and PUT2). Black dashed line: the reactions responsible for arginine degradation to proline and ammoni