Combining different areas of regenerative medicine is considered the new standard for comprehensive tissue and organ regeneration. This approach can be further applied to cosmetic issues such as deep neck lines. This case report utilized techniques of autologous stem cell therapy and epigenetic tissue environment modulation with externally applied polyphenols and tissue penetration agents. The results showed a remarkable cosmetic improvement with a significant reduction of neck lines in a patient where employment and psychological issues were developing from the original problem. The regenerative medicine protocol was safe, efficient in disposable materials, portable benchtop equipment and surgical operating time. The patient had an excellent outcome for this difficult to treat cosmetic problem.
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