The effects of a polyherbal mixture containing Allium sativum, Cinnamomum zeylanicum, Citrullus colocynthis, Juglans regia, Nigella sativa, Olea europaea, Punica granatum, Salvia officinalis, Teucrium polium, Trigonella foenum, Urtica dioica, and Vaccinium arctostaphylos were tested on biochemical parameters in diabetic rats. The animals were randomized into three groups: (1) normal control, (2) diabetic control, and (3) diabetic rats which received diet containing 15% (w/w) of this mixture for 4 weeks. Diabetes was induced by intraperitoneal injection of streptozotocin (55？mg/kg). At the end of experiment, the mixture had no significant effect on serum hepatic enzymes, aspartate aminotransferase, and alanine aminotransferase activities. However, the level of fasting blood glucose, water intake, and urine output in treated group was lower than that in diabetic control rats ( ). Also, the levels of triglyceride and total cholesterol in polyherbal mixture treated rats were significantly lower than those in diabetic control group ( ). Our results demonstrated that this polyherbal mixture has beneficial effects on blood glucose and lipid profile and it has the potential to be used as a dietary supplement for the management of diabetes. 1. Introduction Diabetes mellitus, a metabolic disease with manifestation of hyperglycemia and dyslipidemia, is still one of the most leading causes of death and disability. Over time, diabetes leads to serious complications such as nephropathy, retinopathy, neuropathy, stroke, and peripheral vascular diseases [1]. Currently, beside insulin, the most widely used medications for diabetes are insulin and the oral hypoglycemic drugs [2]. Although early onset manifestations of diabetes can be controlled by current antidiabetic drugs, late onset complications appear in many patients [3]. In addition, the clinical uses of the current drugs are usually accompanied with some adverse effects including abdominal discomfort, severe hypoglycemia, lactic acidosis, and peripheral edema [2]. Therefore, the search for new antidiabetic agents with more effectiveness and lesser side effects has continued. Today, antidiabetic effects of several plants have been supported by results from animal studies or clinical trials. Among them, Allium sativum, Cinnamomum zeylanicum, Citrullus colocynthis, Juglans regia, Nigella sativa, Olea europaea, Punica granatum, Salvia officinalis, Teucrium polium, Trigonella foenum, Urtica dioica, and Vaccinium arctostaphylos are widely used as medicinal plants for management of diabetes [4, 5]. Several studies have
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