The effect of angiotensin receptor blockers on C-reactive protein and other circulating inflammatory indices in man

t of angiotensin receptor blockers on C-reactive protein and other circulating inflammatory indices in man Review (3840) Total Article Views Authors: Alessandra Del Fiorentino, Silvana Cianchetti, Alessandro Celi, Giulia Dell’Omo, Roberto Pedrinelli Published Date February 2009 Volume 2009:5 Pages 233 - 242 DOI: http://dx.doi.org/10.2147/VHRM.S4800 Alessandra Del Fiorentino, Silvana Cianchetti, Alessandro Celi, Giulia Dell’Omo, Roberto Pedrinelli Dipartimento Cardio Toracico e Vascolare, Università di Pisa, Italy Abstract: Anti-inflammatory properties may contribute to the pharmacological effects of angiotensin II receptor blockers (ARBs), a leading therapeutic class in the management of hypertension and related cardiovascular and renal diseases. That possibility, supported by consistent evidence from in-vitro and animal studies showing pro-inflammatory properties of angiotensin II, has been evaluated clinically by measuring the effect of ARBs on C-reactive protein and other circulating indices of inflammation (e-selectin, adhesion molecules, interleukin-6, tissue necrosis factor-alpha, monocyte chemoattractant protein-1) of potential clinical relevance, a body of evidence that this paper aims to review.