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Química Nova 2012
Desenvolvimento e valida??o de método analítico para a determina??o de sulfassalazina em suspens?o oral: compara??o do método espectrofotométrico e de cromatografia líquida de alta eficiência (CLAE)DOI: 10.1590/S0100-40422012000400028 Keywords: sulfasalazine, oral suspension, analytical method. Abstract: sulfasalazine is a prodrug used in the treatment of the chron's disease and rheumatoid arthritis. two analytical methods for analysis of sulfasalazine in oral suspension were validated using spectrophotometric and hplc. there is not any pharmacopoeic method to assay sulfasalazine in oral suspension. the methods are insurance and fast execution for the quality control. both, suspension and tablets 500 mg (azulfin?) had been analyzed by methods using uv/vis and hplc and the results were satisfactory.
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