Factores no biológicos relacionados con el desarrollo de resistencia de Plasmodium falciparum a la cloroquina

the development of plasmodium falciparum resistant to antimalarial drugs constitutes a major public health issue for malaria control. particularly, the emergence and widespread of chloroquine resistant p. falciparum strains in the second half of xx century represents a new challenge to malaria control. the scientific literature has documented factors related to the human host, the vector, the parasite and the treatment, which could explain the selection, survival and local or wide spread of these strains. in this paper are reviewed non-biological factors that could explain the emergency of p. falciparum resistant chloroquine strains. the understanding of these factors is relevant to design strategies to delay the emergence of antimalarial drug resistant parasites.