Reactividad alérgica a Anisakis simplex y su asociación con asma bronquial en ni？os escolares del estado Nueva Esparta, Venezuela

allergic reactivity to anisakis simplex has become in a health problem in many parts of the world. in venezuelan coasts, it has been found infecting marine mammals and also different parasites fishes commonly consumed by human. however, the association of this helminth with the development and severity of allergic reactivity has not been previously evaluated in venezuela. the aim of this study was to evaluate the allergic reactivity to an. simplex in a group 144 children from nueva esparta, state, and its possible relation with bronquial asthma and rhinitis allergic severity. all children were evaluated using a validated socioeconomic questionnaire modified by graffar, and a validate questionnaire according to aria (international consensus report) for allergic rhinitis, gina (who/nih global initiative for asthma) for bronquial asthma and hannifin for atopic dermatitis. surveys were performed in order to evaluate the main sources of allergens to which the study population exposes itself. children physical evaluation and skin prick test were performed, as well as pulmonary function test. we found a high percentage (45%) of children with positive skin prick test to an. simplex. moreover, a greatest prevalence and severity of asthma and rhinitis, was observed in those children with positive skin prick test to an. simplex. since it has been reported the presence of the crossed reactivity between ascaris lumbricoides and an. simplex, it？s important to consider that the high reactivity found to an. simplex might be due to the co-infection with a. lumbricoides. nevertheless, the sensibilization to an. simplex, due by specific or by crossed reactivity exists, and it should be considered by local health authorities in order to prevent the exacerbation of the respiratory pathologies mediated by the consumption of fresh fishes potentially infected.