Doen？a de Graves

graves’disease is the major cause of hyperthyroidism. it is an autoimmune disease of a certainly multifactorial unknown etiology, with genetic predisposition evidence. its frequency, the autoimmune nature and the potentially serious consequences of the untreated disease make it an object of intense investigation, being in mind the best understanding of the pathogenic mechanisms and the discovery of new and more efficient therapeutics, ideally directed against the autoimmune process itself. the authors decided to bring together in this revision the most relevant current knowledge on this subject, in way to optimize the quality of the clinical practice.