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Aspectos inmunológicos en la enfermedad de Parkinson

Keywords: parkinson, neuroinflammation, immunity, neurotrophins.

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Abstract:

parkinson disease is a neurodegenerative disorder that affects 50/100,000 individuals in mexico. parkinson disease is characterized by reduction in dopamine content of the substancia nigra pars compacta resulting in 1055 of domamine-containing neurons. the postulated cause of the disease includes several processes: 1. a growth factor deficiency, such as nerve growth factor and brain-derived neurotrophic factor, cytokines which can prevent and protect neuronal cell death; which may regulate glial phenotype, t lymphocytes and blymphocytes functions, and the surviving pathway signals; 2. dysfunction of the ubiquitin-proteasome system related to the histophatology of this disease; and 3. excitotoxic mechanisms, resulting in information of free radicals and the neuroinflammatory processes leading to autoimmunity or a failing immune response.

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