Síndrome metabólico en la infancia y su asociación con insulinorresistencia

objective. metabolic syndrome is associated with insulin-resistance in adults. we defined pediatric metabolic syndrome using criteria analogous to atpiii. the purpose of this study was to determine if these criteria are reliable for insulin-resistance in children. population, materials and methods. 167 children with an average age of were evaluated (6.7±3 years); 73 with overweight (bmi >95th percentile), 41 at risk of overweight (bmi >85 <95th percentile), and 53 with normal weight (bmi <85th percentile) matched for sex and age. the results for waist circumference, blood pressure, ogtt, c-reactive protein (crp), adiponectin, insulin and lipids were obtained. results. there was a comparable prevalence of metabolic syndrome in both sexes. the prevalence of the metabolic syndrome was 11.3% (95% ci 6.56% to 16.19%) among the whole group and 21.9% (95% ci 12.24% to 31.0%) among overweighted children. risk factors as waist circumference >75th percentile in 53.2% (95% ci 45.73% to 60.86%), and low hdl in 27.5% (95% ci 20.77% to 34.32%), were common in this sample. compared with patients without any component of the metabolic syndrome, homa-ir for patients with one to four components was higher (beta= 0.6; 95% ci, 0.4 - 0.7; p< 0.0001; r2= 0.185). a logistic regression analysis using the metabolic syndrome as the dependent variable showed that homa-ir (or: 1.52; 95%ci, 1.2 - 2.0; p= 0.007) was the only independent risk factor significantly associated the metabolic syndrome, adjusted for age and sex. conclusion. the importance of insulin-resistance in the metabolic syndrome is supported by the results of logistic-regression analysis. early identification of children with metabolic syndrome may be useful to predict future cardiovascular disease and type 2 diabetes.