Posible efecto antioxidante de la atorvastatina en individuos hiperlipidemicos

the atorvastatin is used in the treatment of hyperlipidaemia owing its action of inhibition 3-hydroxy-3-methylglutaryl coenzyme a reductase. additionally, they have showed to reduce oxidative stress and the susceptibility of ldl-c to oxidation. considering these pleiotropic effects of atorvastatin this research was proposed with the objective: to evaluate the possible antioxidant effect of the atorvastatin on the serum levels of α-tocopherol and retinol in hyperlipidemia individuals. methodology: prior informed consent, 30 individuals with hyperlipidemia, was analyzed for lipid profile (enzymatic-colorimetric) and vitamins a and e (hplc) before and after short-term treatment (7 days) with different doses of atorvastatin. results: treatment with 10 mg significantly decreased triglycerides, total cholesterol and ldl-c, (p = 0.0308), (p = 0.031) and (p = 0.0193), an increase of 2.26% in hdl-c. the dose of 20 mg intensified significantly the mentioned effect, triglycerides, total cholesterol and ldl-c (p = 0.0211), (p = 0.0001) and (p = 0.0001), respectively. the values of vitamins a and e showed a significantly increase with dose of 20 mg. conclusion: treatment with atorvastatin at doses of either 10 or 20 mg decreased triglycerides, total cholesterol and ldl-c in a dose-dependent manner. the effect and the increase of vitamin a and e levels could reflect not only a lipid lowering effect, but also a pleiotrópico, in this case antioxidant effect.