Efectos de la administración crónica de alcohol sobre la conducta motora y su relación con el sistema colinérgico muscarinico en ratas Sprague Dawley bajo estrés discontinuos

alcohol consumption and stress are health problems, which affects the cholinergic muscarinic receptor (cmr) system. here we studied the effect of both phenomena on cmr functionality and densities. methods: 43 sprague dawley rats were divided in 4 groups: control (n=11), stress (n=10), alcohol (n=10) and alcohol-stress (n=9). alcohol groups received 10% ethanol ad libitum in substitution of water every day, stress groups were submitted 3 days at week to 5 min force swimming at 5°c. results: rats that had alcohol displayed addiction and hypermotility, the effect was higher at alcohol-stress group. scopolamine significantly increased motility in all groups. no differences were observed at rotarod performance. cmr density was decreased in hippocampus of rats belonging to alcohol group. conclusion: alcohol induces motor disturbances related to cmr system.