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Medifam  2002 

?Sabemos cuáles son los efectos adversos de los medicamentos que recetamos?

DOI: 10.4321/S1131-57682002000800007

Keywords: agranulocytosis, anti-inflammatory agents, non-steroidal, dipyrone, neutropenia, side effects, mortality.

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Abstract:

many of the medicines used daily and which are supposed harmless, may in fact produce numerous side-effects which can, on occasions, be life-threatening. agranulocytosis is an uncommon alteration of the blood consisting of severe neutropenia with serious associated infections and a high mortality rate. a great number of medications have been associated with the production of agranulocytosis: antibiotics, anti-inflammatory, anti-depressants, etc. of these medicines metamizol has been one of the most closely-associated with this blood disorder. widely used, metamizol, is very popular not only in medical circles, but also amongst patients who are able to buy it without prescription from any pharmacy in our country. although the association between agranulocytosis and metamizol is not common, we should be aware of the grave consequences which may arise. this was the case of the patient described who, having taken metamizol, required urgent treatment at home, before being admitted to hospital. emergency room analysis revealed agranulocitosis. the patient was admitted to the intensive care unit where, in spite of support and anti-biotherapy, she died within a few hours.

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