Treatment of oral lichen planus with photodynamic therapy mediated methylene blue: A case report

oral lichen planus (olp) is a common chronic disease of uncertain origin. many patients with olp are refractory to all available therapies. the photodynamic therapy (pdt) was used as a possible alternative method in the treatment of lichen planus. two patients with five oral lichen planus lesions were treated using topical pdt mediated by methylene blue (mb-pdt). the patients were followed up on sessions 3, 7, 15 days and 1 to 9 months after pdt. clinical improvement was achieved in four lesions. two lesions showed complete remission, and another two lesions had about 50% clinically improvement 3-9 months after a single session of pdt. no response detected in one lesion. mb-pdt blue seems to be an effective alternative treatment for control of olp. in our opinion, this preliminary result warrant further studies in order to show the efficacy of mb-pdt in control of olp for a longer period of time.