Epidermodisplasia verruciforme: tratamento combinado com acitretina e interferon alfa-2a

we report the result of a treatment with acitretin and alpha-2a interferon in a 16-year-old boy with epidermodysplasia verruciformis. diagnosis was based on clinical features, histopathological examination and positivity for in situ hpv. the affection was extensive and resistant to other treatment modalities, with a high risk of development of neoplasias. treatment with oral acitretin associated with subcutaneous recombinant interferon alpha-2a three times per week induced improvement, which was sustained for 16 months of follow-up.