Malignancy related hypercoagulobility can manifest as acute arterial infarction, non-bacterial thrombotic endocarditis and thrombophlebitis. Rarely, ischemic stroke may be first symptom for a systemic occult cancer. We presented 62-year-old man who had recurrent stroke as the initial manifestation of an occult neoplastic process. Subsequently, the patient had venous thrombotic disease that led to the diagnosis of the malignancy. Conclusions: Acute or sub-acute multiple ischemic stroke may be the first manifestation of in an occult cancer.
References
[1]
G. Y. Lip, B. S. Chin and A. D. Blann, “Cancer and the Prothrombotic State,” The Lancet Oncology, Vol. 3, No. 1, 2002, pp. 27-34. doi:10.1016/S1470-2045(01)00619-2
[2]
A. A. Khorana and R. L. Fine, “Pancreatic Cancer and Thromboembolic Disease,” The Lancet Oncology, Vol. 5, No. 11, 2004, pp. 655-663.
doi:10.1016/S1470-2045(04)01606-7
[3]
A. Varki, “Trousseau’s Syndrome: Multiple Definitions and Multiple Mechanisms,” Blood, Vol. 110, No. 6, 2007, pp. 1723-1729. doi:10.1182/blood-2006-10-053736
[4]
L. R. Rogers, “Cerebrovascular Complications in Cancer Patients,” Neurologic Clinics, Vol. 21, No.1, 2003, pp. 167-192. doi:10.1016/S0733-8619(02)00066-X
[5]
E. E. Rigdon, “Trousseau’s Syndrome and Acute Arterial Thrombosis,” Journal of Cardiovascular Surgery, Vol. 8, No. 3, 2000, pp. 214-218.
[6]
S. Giray, B. F. Sarica, Z. Arlier and N. Bal, “Recurrent Ischemic Stroke as an Initial Manifestation of an Concealed Pancreatic Adenocarcinoma: Trousseau’s Syndrome,” Chinese Medical Journal, Vol. 124, No. 4, 2011, pp. 637-640.
[7]
R. Clarke, J. Halsey, D. Bennett and S. Lewington, “Homocysteine and Vascular Disease: Review of Published Results of the Homocysteine-Lowering Trials,” Journal of Inherited Metabolic Disease, Vol. 34, No. 1, 2011, pp. 83-91. doi:10.1007/s10545-010-9235-y
[8]
O. Y. Bang, J. M. Seok, S. G. Kim, J. M. Hong, H. Y. Kim, J. Lee, P. W. Chung, K. Y. Park, G. M. Kim, C. S. Chung and K. H. Lee, “Ischemic Stroke and Cancer: Stroke Severely Impacts Cancer Patients, While Cancer Increases the Number of Strokes,” Journal of Clinical Neurology, Vol. 7, No. 2, 2011, pp. 53-59.
doi:10.3988/jcn.2011.7.2.53
[9]
P. J. Saylor and A. E. Fogerty, “Prostate-Cancer-Associated Hypercoagulability: Do We Need to Worry about Androgen Deprivation?” The Lancet Oncology, Vol. 11, No. 5, 2010, pp. 406-407.
doi:10.1016/S1470-2045(10)70063-2
