Metallochlorophylls of magnesium, copper and zinc: evaluation of the influence of the first coordination sphere on their solvatochromism and aggregation properties

in this study the role of different metal centers (magnesium, zinc and copper) on the enhancement of the hydrophilic character of metallochlorophylls, was evaluated. the solvatochromism as well as the aggregation process for these compounds in water/ethanol mixtures at different volume ratios were evaluated using fluorescence, and resonant light scattering (rls) measurements, aiming to characterize the behavior of these compounds. independently on the studied metallochlorophyll, the presence of at least 60% of water results in a considerable increase in the fluorescence emission, probably a direct consequence of a lower aggregation of these compounds, which is confirmed by the results from rls measurements. additionally, the results suggest that magnesium and zinc chlorophyll should be promising phototherapeutic agents for photodynamic therapy.